Masaki Isoda,Atsushi Noritake,Taihei Ninomiya
Masaki Isoda
This paper reviews the literature on social neuroscience studies using macaques in the hope of encouraging as many researchers as possible to participate in this field of research and thereby accelerate the system-level understanding of soc...
Nobuo Yanagisawa
Nobuo Yanagisawa
Involuntary movements and parkinsonism have been interesting and important topics in neurology since the last century. The development of anatomical and physiological studies of the neural circuitry of motor systems has encouraged the study...
Masahiro Oka,Yoshihiro Yoneda
Masahiro Oka
Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular mechanisms underlying nuclear transport that involve the nuclear transport receptor, small GTPase Ran, and the nuclear pore complex are highly conserved from y...
Post-transcriptional regulation of immune responses by RNA binding proteins [0.03%]
RNA结合蛋白对免疫反应的转录后调控
Takashi Mino,Osamu Takeuchi
Takashi Mino
Cytokines are critical mediators of inflammation and host immune defense. Cytokine production is regulated at both transcriptional and post-transcriptional levels. Post-transcriptional damping of inflammatory mRNAs is mediated by a set of R...
The causal relationship between epigenetic abnormality and cancer development: in vivo reprogramming and its future application [0.03%]
表观遗传异常与肿瘤发生发展的因果关系：体内重编程及其未来应用前景
Yosuke Yamada,Yasuhiro Yamada
Yosuke Yamada
There is increasing evidence that cancer cells acquire epigenetic abnormalities as well as genetic mutations during cancer initiation, maintenance, and progression. However, the role of epigenetic regulation in cancer development, especiall...
Akira Hasegawa
Akira Hasegawa
I reviewed studies on the inhomogeneous seismic structure of the mantle wedge in subduction zones, in relation to corner flow and its implications for arc magmatism. Seismic studies in Tohoku clearly imaged the descending flow portion of th...
Unique sex determination system in the silkworm, Bombyx mori: current status and beyond [0.03%]
家蚕性别决定系统的独特性：现状与未来展望
Susumu Katsuma,Takashi Kiuchi,Munetaka Kawamoto et al.
Susumu Katsuma et al.
The silkworm Bombyx mori has been used for silk production for over 5,000 years. In addition to its contribution to sericulture, B. mori has played an important role in the field of genetics. Classical genetic studies revealed that a gene(s...
MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes [0.03%]
基于MPF调控的减数分裂细胞周期控制：来自海星卵母细胞研究五十年的经验与教益
Takeo Kishimoto
Takeo Kishimoto
In metazoans that undergo sexual reproduction, genomic inheritance is ensured by two distinct types of cell cycle, mitosis and meiosis. Mitosis maintains the genomic ploidy in somatic cells reproducing within a generation, whereas meiosis r...
Akira Isogai
Akira Isogai
Plant cellulose fibers of width and length ∼0.03 mm and ∼3 mm, respectively, can be completely converted to individual cellulose nanofibers of width and length ∼3 nm and ∼1 µm, respectively, by 2,2,6,6-tetramethylpiperidine-1-oxyl radi...
Adjuvant immunotherapy for cancer: both dendritic cell-priming and check-point inhibitor blockade are required for immunotherapy [0.03%]
癌症免疫辅助治疗：基于树突状细胞激活及检查点抑制剂阻断的联合免疫治疗
Tsukasa Seya,Yohei Takeda,Ken Takashima et al.
Tsukasa Seya et al.
The immune system eliminates advanced cancer when treated with programmed cell death protein-1 (PD-1) or its ligand (PD-L1) blockade, but PD-1 therapy is effective in only ∼20% of patients with solid cancer. The PD-1 antibody mainly acts o...