Toshihiko Hosoya
Toshihiko Hosoya
The fundamental organization of the cerebral cortical circuit is still poorly understood. In particular, it is unclear whether the diverse cell types form modular units that are repeated across the cortex. We discovered that the major cell ...
Production of the herb Ruta chalepensis L. expressing amyloid β-GFP fusion protein [0.03%]
生产含有淀粉样蛋白β-GFP融合蛋白的拉塔切莱彭西斯植物zych
Taiji Yoshida,Yuichiro Watanabe,Shoichi Ishiura
Taiji Yoshida
The herb Ruta chalepensis L. exhibits medical effects, such as anti-inflammatory, central nervous system depressant, and antipyretic activities. However, a genetic transformation method has not yet been developed for this species. In this p...
Shoichi Ishiura,Taiji Yoshida
Shoichi Ishiura
Alzheimer's disease (AD) is one of the major causes of chronic and progressive cognitive decline, with the pathological hallmarks of senile plaques and neurofibrillary tangles. Amyloid β peptide (Aβ) is the main component of senile plaque...
Naoto Nagaosa
Naoto Nagaosa
Electrons in solids constitute quantum many-body systems showing a variety of phenomena. It often happens that the eigen states of the Hamiltonian are classified into subgroups separated by energy gaps. Band structures in solids and spin po...
Masamitsu Futai,Ge-Hong Sun-Wada,Yoh Wada et al.
Masamitsu Futai et al.
Vacuolar-type ATPase (V-ATPase), initially identified in yeast and plant vacuoles, pumps protons into the lumen of organelles coupled with ATP hydrolysis. The mammalian counterpart is found ubiquitously in endomembrane organelles and the pl...
Glutamate as intracellular and extracellular signals in pancreatic islet functions [0.03%]
胰岛功能中的细胞内外谷氨酸信号作用
Harumi Takahashi,Norihide Yokoi,Susumu Seino
Harumi Takahashi
l-Glutamate is one of the most abundant amino acids in the body and is a constituent of proteins and a substrate in metabolism. It is well known that glutamate serves as a primary excitatory neurotransmitter and a critical neuromodulator in...
Global warming and rice production in Asia: Modeling, impact prediction and adaptation [0.03%]
气候变化对亚洲水稻生产的影响及适应性研究模型
Takeshi Horie
Takeshi Horie
Since the projection of global warming emerged in 1980s with the potential of laying enormous impacts on agriculture and food security of the world, we have conducted experimental and modeling studies for clarifying its effects on rice prod...
Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases [0.03%]
脑脊液转铁蛋白亚型及其与神经疾病的关系
Yuta Murakami,Kiyoshi Saito,Hiromi Ito et al.
Yuta Murakami et al.
Iron plays many important roles in the brain, including involvement in myelination, neurotransmission and electron transfer in the respiratory chain. Transferrin (Tf), an iron transporter, is mainly biosynthesized in the liver, but can also...
Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model [0.03%]
精神分裂症的突触功能及其破坏：从临床证据到动物模型中的突触光遗传学
Kisho Obi-Nagata,Yusuke Temma,Akiko Hayashi-Takagi
Kisho Obi-Nagata
The adult human brain consists of approximately a hundred billion neurons, which are connected via synapses. The pattern and strength of the synaptic connections are constantly changing (synaptic plasticity), and these changes are considere...
Hypervelocity collision and water-rock interaction in space preserved in the Chelyabinsk ordinary chondrite [0.03%]
切巴尔金普通球粒陨石中的超高速碰撞和水岩相互作用痕迹
Eizo Nakamura,Tak Kunihiro,Tsutomu Ota et al.
Eizo Nakamura et al.
A comprehensive geochemical study of the Chelyabinsk meteorite reveals further details regarding its history of impact-related fragmentation and melting, and later aqueous alteration, during its transit toward Earth. We support an ∼30 Ma a...