Hiroshi Hamada
Hiroshi Hamada
Although the human body appears superficially symmetrical with regard to the left-right (L-R) axis, most visceral organs are asymmetric in terms of their size, shape, or position. Such morphological asymmetries of visceral organs, which are...
Progress in individualized treatment for EGFR-mutated advanced non-small cell lung cancer [0.03%]
EGFR突变型晚期非小细胞肺癌个体化治疗进展
Akira Inoue
Akira Inoue
The identification of mutations in the epidermal growth factor receptor (EGFR) gene has revolutionized the treatment strategy for non-small cell lung cancer (NSCLC). The effectiveness of individualized treatment using EGFR tyrosine kinase i...
Tadao Kakizoe
Tadao Kakizoe
More than 90% of bladder cancer is composed of transitional cell carcinoma (TCC), being characterized by the development of multiple tumors in the entire urinary tract over time. When cystectomy is conducted, the urinary tract must be recon...
Fundamental research on semiconductor SiC and its applications to power electronics [0.03%]
宽禁带半导体碳化硅基础研究及电力电子应用
Hiroyuki Matsunami
Hiroyuki Matsunami
Today, the silicon carbide (SiC) semiconductor is becoming the front runner in advanced power electronic devices. This material has been considered to be useful for abrasive powder, refractory bricks as well as ceramic varistors. Big change...
Yoichiro Suzuki
Yoichiro Suzuki
In the standard model of elementary particle physics neutrinos are massless, and therefore the actuality of finite neutrino mass indicates a theory beyond the standard model. The Sun produces abundant neutrinos due to nuclear fusion reactio...
Takumi Ito,Hiroshi Handa
Takumi Ito
Thalidomide, originally developed as a sedative drug, causes multiple defects due to severe teratogenicity, but it has been re-purposed for treating multiple myeloma, and derivatives such as lenalidomide and pomalidomide have been developed...
Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane [0.03%]
1,4-丁内酯处理大鼠肝脏中的DNA加合物的综合分析（DNA加合组学分析）
Yukari Totsuka,Yuya Maesako,Hanako Ono et al.
Yukari Totsuka et al.
1,4-Dioxane is a genotoxic carcinogen, and its mutagenic properties were recently observed in the liver of guanine phosphoribosyl transferase (gpt) delta transgenic rats. However, the mechanisms of its genotoxicity remain unclear. We analyz...
Differential expression of DNA-dependent protein kinase catalytic subunit in the brain of neonatal mice and young adult mice [0.03%]
新生小鼠和年轻成年小鼠大脑中DNA依赖性蛋白激酶催化亚基的差异表达
Aoi Okawa,Takamitsu Morioka,Tatsuhiko Imaoka et al.
Aoi Okawa et al.
It is generally thought that younger people are more susceptible to cancer development after exposure to ionizing radiation in reference to epidemiological studies and animal experiments. However, little is known about the age-dependent alt...
Osteoimmunology - Bidirectional dialogue and inevitable union of the fields of bone and immunity [0.03%]
骨免疫学-骨骼与免疫领域双向对话及不可分割的联系
Hiroshi Takayanagi
Hiroshi Takayanagi
Bone is a critically important part of the skeletal system that is essential for body support and locomotion. The immune system protects against pathogens and is active in host defense. These two seemingly distinct systems in fact interact ...
Direct cell-fate conversion of somatic cells: Toward regenerative medicine and industries [0.03%]
直接重编程体细胞为目标细胞：通向再生医学和产业的新途径
Kenichi Horisawa,Atsushi Suzuki
Kenichi Horisawa
Cells of multicellular organisms have diverse characteristics despite having the same genetic identity. The distinctive phenotype of each cell is determined by molecular mechanisms such as epigenetic changes that occur throughout the lifeti...