Heterologous production of fungal natural products: Reconstitution of biosynthetic gene clusters in model host Aspergillus oryzae [0.03%]
异源生产真菌次生代谢产物：在解淀粉芽孢杆菌模式宿主中重构基因簇
Hideaki Oikawa
Hideaki Oikawa
While exploring phytotoxic metabolites from phytopathogenic fungi in the 1970s, we became interested in biosynthetic enzymes that catalyze Diels-Alder reactions involving biosynthesis of several phytotoxins that we isolated. Target enzymes ...
Current understanding of the global cycling of carbon dioxide, methane, and nitrous oxide [0.03%]
关于二氧化碳、甲烷和氧化亚氮全球循环的当前认识
Takakiyo Nakazawa
Takakiyo Nakazawa
To address the climate change caused by anthropogenic emissions of greenhouse gases into the atmosphere, it is essential to understand and quantitatively elucidate their cycling on the Earth's surface. This paper first presents an overview ...
Theory of particle transport phenomena during fatigue and time-dependent fracture of materials based on mesoscale dynamics and their practical applications [0.03%]
基于介观动力学的材料疲劳与时间依赖损伤过程中粒子输运理论及其工程应用基础研究
A Toshimitsu Yokobori Jr
A Toshimitsu Yokobori Jr
In this work, the mesoscale mechanics of metals, which links their microscopic physics and macroscopic mechanics, was established. For practical applications, the laws for quantitatively predicting life of cycle and time-dependent fracture ...
Kazushige Obara
Kazushige Obara
APPL1 negatively regulates bone mass, possibly by controlling the fate of bone marrow mesenchymal progenitor cells [0.03%]
APPL1通过控制骨髓间充质前体细胞的命运来负向调控骨量
Yuan-Yu Lin,Lily Q Dong
Yuan-Yu Lin
Adiponectin is an adipokine that can exert a regulatory function on bone metabolism. However, there are many contradictions between clinical and pre-clinical studies on adiponectin. APPL1 is an adaptor protein that can interact with adipone...
The significance of gene expression dynamics in neural stem cell regulation [0.03%]
基因表达动态在神经干细胞调控中的意义
Ryoichiro Kageyama,Shohei Ochi,Risa Sueda et al.
Ryoichiro Kageyama et al.
Neural stem cells (NSCs) actively proliferate and generate neurons and glial cells (active state) in the embryonic brain, whereas they are mostly dormant (quiescent state) in the adult brain. The expression dynamics of Hes1 are different be...
On the origin of the optical and near-infrared extragalactic background light [0.03%]
关于光学和近红外星系外背景光的起源
Toshio Matsumoto
Toshio Matsumoto
In optical and near-infrared background light, excess brightness and fluctuation over the known backgrounds have been reported. To delineate their origin, a fluctuation analysis of the deepest optical images was performed, leading to the de...
Groundwater oxygen anomaly related to the 2016 Kumamoto earthquake in Southwest Japan [0.03%]
与2016年日本西南部熊本地震有关的地下水氧异常
Yuji Sano,Satoki Onda,Takanori Kagoshima et al.
Yuji Sano et al.
Here, we report the groundwater oxygen isotope anomalies caused by the 2016 Kumamoto earthquake (MJMA7.3) that occurred in Southwest Japan on April 16, 2016. One hundred and seventeen groundwater samples were collected from a deep well loca...
Hiroyuki Mano
Hiroyuki Mano
Advances in cancer research have revolutionized the way cancer is diagnosed and treated. Any cancer is now known to be an amalgamation of many subtypes, each carrying its specific cancer-causing gene or oncogene. It is also evident that a g...
Kazushige Obara
Kazushige Obara
Slow earthquakes are a recently discovered phenomenon that mainly occur updip and downdip of the seismogenic zones of great earthquakes along the subducting plate interface. The spatiotemporal activity of various slow earthquakes occurring ...