Production scheme for diagnostic-therapeutic radioisotopes by accelerator neutrons [0.03%]
加速中子生产诊断治疗同位素的方案研究
Yasuki Nagai
Yasuki Nagai
Interest has been growing in the development of medical radioisotopes used for noninvasive nuclear medicine imaging of disease and cancer therapy. Especially the development of an alternative production scheme of 99Mo, the mother radioisoto...
SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance [0.03%]
细胞因子信号和转录的负调节因子 SOCS、SPRED 和 NR4A在免疫耐受中的作用
Akihiko Yoshimura,Daisuke Aki,Minako Ito
Akihiko Yoshimura
Cytokines are important intercellular communication tools for immunity. Most cytokines utilize the JAK-STAT and Ras-ERK pathways to promote gene transcription and proliferation; however, this signaling is tightly regulated. The suppressor o...
Development of a cell-free protein synthesis system for practical use [0.03%]
一种用于实际生产的无细胞蛋白质合成系统的开发
Yaeta Endo
Yaeta Endo
Conventional cell-free protein synthesis systems had been the major platform to study the mechanism behind translating genetic information into proteins, as proven in the central dogma of molecular biology. Albeit being powerful research to...
Advanced time-resolved absorption spectroscopy with an ultrashort visible/near IR laser and a multi-channel lock-in detector [0.03%]
具有超短可见光/近红外激光和多通道锁相放大检测的高时间分辨吸收光谱技术
Takayoshi Kobayashi
Takayoshi Kobayashi
Ultrashort visible-near infrared (NIR) pulse generation and its applications to ultrafast spectroscopy are discussed. Femtosecond pulses of around 800 nm from a Ti:sapphire laser are used as a pump of an optical parametric amplifier (OPA) i...
Tomio Kobayashi
Tomio Kobayashi
The history concerning an experimental verification of the standard model of particle physics is reviewed with special emphasis on results from experiments using the highest-energy particle colliders, namely, PETRA, LEP and LHC. This articl...
Corrigenda to "LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling" [0.03%]
"LUBAC介导的线性泛素化：调控免疫信号的关键调节因子”的勘误表
Kazuhiro Iwai
Kazuhiro Iwai
Optical manipulation of molecular function by chromophore-assisted light inactivation [0.03%]
基于发色团辅助光灭活的分子功能光学调控方法研究
Kiwamu Takemoto
Kiwamu Takemoto
In addition to simple on/off switches for molecular activity, spatiotemporal dynamics are also thought to be important for the regulation of cellular function. However, their physiological significance and in vivo importance remain largely ...
Teruo Miyazawa
Teruo Miyazawa
Research on lipid peroxidation in food degradation, oil and fat nutrition, and age-related diseases has gained significant international attention for the view of improvement of societal health and longevity. In order to promote basic studi...
TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NF-κB activation [0.03%]
TRAF6通过聚泛素化活化NF-κB在多个生物系统中发挥关键作用
Mizuki Yamamoto,Jin Gohda,Taishin Akiyama et al.
Mizuki Yamamoto et al.
NF-κB was first identified in 1986 as a B cell-specific transcription factor inducing immunoglobulin κ light chain expression. Subsequent studies revealed that NF-κB plays important roles in development, organogenesis, immunity, inflamma...
Multi-dimensional diffusion process of allele frequencies in population genetics [0.03%]
群体遗传学中的等位基因频率的多维扩散过程
Hideki Innan,Takahiro Sakamoto
Hideki Innan
One of the ultimate goals of population genetics is to theoretically describe the behavior of allele frequency. Diffusion theory has been commonly used for this purpose mainly in one-locus one-population models, although it is not easy to h...