Operating principles of the cerebral cortex as a six-layered network in primates: beyond the classic canonical circuit model [0.03%]
灵长类大脑皮层的六层网络运行机制：经典“典范环路”的局限性
Yasushi Miyashita
Yasushi Miyashita
The cerebral cortex performs its computations with many six-layered fundamental units, collectively spreading along the cortical sheet. What is the local network structure and the operating dynamics of such a fundamental unit? Previous inve...
Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans [0.03%]
调节秀丽隐杆线虫冷耐受和低温适应的分子生理学
Misaki Okahata,Haruka Motomura,Akane Ohta et al.
Misaki Okahata et al.
Many organisms can survive and proliferate in changing environmental temperatures. Here, we introduce a molecular physiological mechanism for cold tolerance and acclimation of the nematode Caenorhabditis elegans on the basis of previous rep...
RET receptor signaling: Function in development, metabolic disease, and cancer [0.03%]
RET受体信号转导：在发育、代谢性疾病和癌症中的功能
Masahide Takahashi
Masahide Takahashi
The RET proto-oncogene encodes a receptor tyrosine kinase whose alterations are responsible for various human cancers and developmental disorders, including thyroid cancer, non-small cell lung cancer, multiple endocrine neoplasia type 2, an...
An interpretation of COVID-19 in Tokyo using a combination of SIR models [0.03%]
结合SIR模型解释东京的COVID-19疫情
Koichiro Maki
Koichiro Maki
A year and a half has passed since the outbreak of the COVID-19 pandemic. Mathematical models to predict infection are expected and many studies have been conducted. In this study, a new interpretation was created that could reproduce the d...
Implications of glutathione-S transferase P1 in MAPK signaling as a CRAF chaperone: In memory of Dr. Irving Listowsky [0.03%]
谷胱甘肽-S转移酶P1作为CRAF伴侣在MAPK信号传导中的意义：纪念伊尔文·利斯托斯基博士
Yoshiro Niitsu,Yasushi Sato,Tetsuji Takayama
Yoshiro Niitsu
Glutathione-S transferase P1 (GSTP1) is one of the glutathione-S transferase isozymes that belong to a family of phase II metabolic isozymes. The unique feature of GSTP1 compared with other GST isozymes is its relatively high expression in ...
Teruyuki Kato,Yukihiro Terada,Keiichi Tadokoro et al.
Teruyuki Kato et al.
A global navigation satellite system (GNSS) buoy system for early tsunami warnings has been developed for more than 20 years. The first GNSS buoy system using a real-time kinematic algorithm (RTK) was implemented in the Nationwide Ocean Wav...
Possibilities and challenges of small molecule organic compounds for the treatment of repeat diseases [0.03%]
小分子有机化合物治疗重复性疾病的可能性与挑战
Kazuhiko Nakatani
Kazuhiko Nakatani
The instability of repeat sequences in the human genome results in the onset of many neurological diseases if the repeats expand above a certain threshold. The transcripts containing long repeats sequester RNA binding proteins. The mechanis...
Yu Nakagawa,Yukishige Ito
Yu Nakagawa
Pradimicins (PRMs) are an exceptional family of natural products that specifically bind d-mannose (Man). In the past decade, their scientific significance has increased greatly, with the emergence of biological roles of Man-containing glyca...
Structural studies of functional nucleosome complexes with transacting factors [0.03%]
具有转录作用因子的功能核小体复合物的结构研究
Hitoshi Kurumizaka
Hitoshi Kurumizaka
In eukaryotic cells, the genomic DNA is hierarchically organized into chromatin. Chromatin structures and dynamics influence all nuclear functions that are guided by DNA, and thus regulate gene expression. Chromatin structure aberrations ca...
New insights into the regulation of synaptic transmission and plasticity by the endoplasmic reticulum and its membrane contacts [0.03%]
内质网及其膜接触在突触传递和可塑性调控中的新见解
Masafumi Tsuboi,Yusuke Hirabayashi
Masafumi Tsuboi
Mammalian neurons are highly compartmentalized yet very large cells. To provide each compartment with its distinct properties, metabolic homeostasis and molecular composition need to be precisely coordinated in a compartment-specific manner...