Metabolomics of clinical samples reveal the treatment mechanism of lanthanum hydroxide on vascular calcification in chronic kidney disease [0.03%]
临床样本代谢组学揭示了氢氧化镧治疗慢性肾脏病血管钙化的机制
Chao Gu,Yuan Gao,Ruilan Han et al.
Chao Gu et al.
Previous studies showed that lanthanum hydroxide (LH) has a therapeutic effect on chronic kidney disease (CKD) and vascular calcification, which suggests that it might have clinical value. However, the target and mechanism of action of LH a...
Design and synthesis of biologically active carbaglycosylamines: From glycosidase inhibitors to pharmacological chaperones [0.03%]
生物活性卡巴糖基胺的设计与合成：从糖苷酶抑制剂到药物伴侣分子
Seiichiro Ogawa,Shinichi Kuno,Tatsushi Toyokuni
Seiichiro Ogawa
For over 50 years, our group has been involved in synthetic studies on biologically active cyclitols including carbasugars. Among a variety of compounds synthesized, this review focuses on carbaglycosylamine glycosidase inhibitors, highligh...
Therapeutic siRNA targeting the cancer cell stemness regulator PRDI-BF1 and RIZ domain zinc finger protein 14 [0.03%]
针对癌症干细胞调控因子PRDI-BF1和RIZ型锌指蛋白14的治疗性siRNA
Kohzoh Imai,Hiroaki Taniguchi
Kohzoh Imai
PRDI-BF1 and RIZ (PR) domain zinc finger protein 14 (PRDM14), first reported in 2007 to be overexpressed in breast cancer, plays an important role in breast cancer proliferation. Subsequent studies reported that PRDM14 is expressed in embry...
Masaharu Noda,Takashi Matsuda
Masaharu Noda
Extracellular fluids, including blood, lymphatic fluid, and cerebrospinal fluid, are collectively called body fluids. The Na+ concentration ([Na+]) in body fluids is maintained at 135-145 mM and is broadly conserved among terrestrial animal...
On the origin and evolution of the asteroid Ryugu: A comprehensive geochemical perspective [0.03%]
龙宫小行星的起源和演化：综合地球化学视角
Eizo Nakamura,Katsura Kobayashi,Ryoji Tanaka et al.
Eizo Nakamura et al.
Presented here are the observations and interpretations from a comprehensive analysis of 16 representative particles returned from the C-type asteroid Ryugu by the Hayabusa2 mission. On average Ryugu particles consist of 50% phyllosilicate ...
Kyoko Nozaki
Kyoko Nozaki
Introduction of functional groups on polyethylene endows it with a higher surface property and thus various catalysts have been developed for the copolymerization of ethylene with polar vinyl monomers. Aside from vinyl monomers, however, ot...
Multiple roles of endocytosis and autophagy in intracellular remodeling during oocyte-to-embryo transition [0.03%]
卵子到胚胎过渡期间细胞内重塑的胞吞作用和自噬的多种作用
Ken Sato
Ken Sato
Fertilization is the starting point for creating new progeny. At this time, the highly differentiated oocyte and sperm fuse to form one zygote, which is then converted into a pluripotent early embryo. Recent studies have shown that the lyso...
Hideki Yorimitsu,Gregory J P Perry
Hideki Yorimitsu
Biaryl synthesis continues to occupy a central role in chemical synthesis. From blockbuster drug molecules to organic electronics, biaryls present numerous possibilities and new applications continue to emerge. Transition-metal-catalyzed co...
Tsunenobu Kimoto
Tsunenobu Kimoto
Silicon carbide (SiC) power devices significantly outperform the well-established silicon (Si) devices in terms of high breakdown voltage, low power loss, and fast switching. This review briefly introduces the major features of SiC power de...
Quantum simulation of quantum many-body systems with ultracold two-electron atoms in an optical lattice [0.03%]
利用光学晶格中双电子冷原子量子模拟量子多体系统
Yoshiro Takahashi
Yoshiro Takahashi
Ultracold atoms in an optical lattice provide a unique approach to study quantum many-body systems, previously only possible by using condensed-matter experimental systems. This new approach, often called quantum simulation, becomes possibl...