Long-term effectiveness and safety of daily growth hormone therapy in Japanese children with Noonan syndrome: a post-marketing surveillance study [0.03%]
长期生长激素治疗Noonan综合征日本儿童的有效性和安全性：上市后监测研究
Koji Muroya,Masanobu Kawai,Hiroyuki Yamagishi et al.
Koji Muroya et al.
Reports on long-term safety and effectiveness of daily GH replacement therapy in Japanese children with short stature due to Noonan syndrome (NS) are limited. This post-marketing, prospective, non-interventional study (ClinicalTrials.gov NC...
Congenital adrenal hypoplasia with neurodevelopmental delay due to contiguous Xp21 deletion: a case series with review of literature [0.03%]
Xp21区带连续性缺失导致的先天肾上腺发育不全合并神经发育障碍：一组病例及文献复习
Maki Gau,Ryosei Iemura,Ryuta Orimoto et al.
Maki Gau et al.
X-linked adrenal hypoplasia congenita (AHC) is a rare, life-threatening disorder caused by pathogenic variants in NR0B1 (DAX1), leading to adrenal insufficiency and hypogonadotropic hypogonadism. AHC is often associated with Xp21 contiguous...
Unintentional discontinuation of topical corticosteroids after emergency hospitalization can exacerbate adrenal insufficiency [0.03%]
在急诊住院后意外中断外用皮质类固醇治疗会加重肾上腺功能不全
Hiroya Kitsunai,Yumika Watanabe,Eisuke Nishikawa et al.
Hiroya Kitsunai et al.
Palopegteriparatide in Japanese adults with hypoparathyroidism: 52-week results from the phase 3 PaTHway Japan trial [0.03%]
日本成人低甲状旁腺素血症患者的palopega特立帕肽治疗：III期PaTHway Japan研究的第52周结果
Kenji Ashida,Masatoshi Nomura,Noriko Makita et al.
Kenji Ashida et al.
PaTHway Japan is an ongoing, phase 3, multicenter, single-arm, open-label trial comprised of a 26-week efficacy period with an extension period through week 182 designed to demonstrate the efficacy, safety, and tolerability of palopegteripa...
Maki Fukami,Kohji Okamura,Shoko Sasaki et al.
Maki Fukami et al.
Males and females show significant differences in body structure, typical behavior, average life expectancy, and disease susceptibility. This review article introduces the current understanding and recent findings on the factors that lead t...
Genetic screening of the insulin-like growth factor 1 receptor gene in children born small for gestational age: the continuing importance of insulin-like growth factor 1 signaling [0.03%]
胰岛素样生长因子1受体基因在宫内发育迟缓儿童中的遗传筛查：胰岛素样生长因子1信号通路的持续重要性
Jun-Hong Park,Yena Lee,Hwal Rim Jeong et al.
Jun-Hong Park et al.
Children born small for gestational age (SGA) who fail to experience catch-up growth often remain short-statured with heterogeneous etiologies, including genetic factors. This study aimed to investigate Insulin-like Growth Factor 1 Receptor...
Association of HLA-DRB1 pocket structures with susceptibility and prognosis of Graves' and Hashimoto's disease [0.03%]
HLA-DRB1袋结构与Graves病和桥本病遗传易感性和预后的关联性研究
Yusuke Noguchi,Yuya Arakawa,Naoya Inoue et al.
Yusuke Noguchi et al.
The physical and/or electrical properties of the peptide-binding pockets of Human Leukocyte Antigen (HLA) class II molecules vary depending on their amino acid sequence, influencing peptide-binding affinity. Previous studies have reported a...
Differences in thyroid hormone prescribing practices between Japan Thyroid Association-certified thyroid specialists and non-certified members: a nationwide survey in Japan [0.03%]
日本甲状腺协会认证的甲状腺专科医生与非认证会员之间甲状腺激素处方习惯差异：一项全国调查研究
Yuji Nagayama,Junichi Tajiri,Tsukasa Murakami et al.
Yuji Nagayama et al.
Thyroid hormone (TH) prescribing practices, particularly on hypothyroid and euthyroid patients, were compared between Japan Thyroid Association (JTA)-certified thyroid specialists and non-certified members. A nationwide questionnaire survey...
Diagnostic criteria for acquired hypothalamic obesity - international expert guidance document [0.03%]
获得性下丘脑肥胖的诊断标准-国际专家指导文件
Hermann L Müller,Tomohiro Tanaka,Tomonobu Hasegawa et al.
Hermann L Müller et al.
Acquired hypothalamic obesity (aHO) presents as rapid, clinically relevant, and persistent weight gain due to hypothalamic damage, and leads to significant morbidity/mortality and decreased quality of life. Causes include craniopharyngioma ...
Comparison of two puncture techniques for fine-needle capillary biopsy in thyroid nodules: a randomized controlled trial [0.03%]
甲状腺结节细针毛细血管活检两种穿刺技术的比较：一项随机对照试验
Pengfei Luo,Wei Ma,Yingguo Jia et al.
Pengfei Luo et al.
To-and-fro puncture and to-and-fro whirling puncture are two common specimen acquisition methods of thyroid fine-needle capillary (FNC) biopsy. While both techniques are widely used, a direct comparison of their outcomes has been lacking. T...