Elevated autoantibodies against dipeptidyl peptidase-4 are associated with poor prognosis in patients with type 2 diabetes [0.03%]
第2型糖尿病患者中针对二肽基肽酶-4的自身抗体水平升高与预后不良相关
Takeshi Yagihashi,Takahide Hashimoto,Naoki Ohtake et al.
Takeshi Yagihashi et al.
Dipeptidyl peptidase-4 (DPP4) is involved in immune regulation and metabolic homeostasis. Although DPP4 inhibitors are widely used in type 2 diabetes, the clinical relevance of autoantibodies against DPP4 (DPP4-Ab) remains unclear. In this ...
Real-world clinical outcomes of tirzepatide administration in older patients with type 2 diabetes, with a focus on the risk of hypoglycemia and weight loss-related parameters [0.03%]
胰升糖素样肽-1/胰多肽受体激动剂特利普肽治疗2型糖尿病老年患者的临床疗效及低血糖和减重相关参数的影响
Hiroya Kitsunai,Fumika Maruyama,Yukie Miyano et al.
Hiroya Kitsunai et al.
In an aging society, the establishment of safe and effective treatment strategies for older patients with type 2 diabetes is crucial. We performed a secondary analysis of the Hokkaido-TZP study (UMIN000056962), evaluating the real-world out...
Gender distribution in membership, leadership, and conference participation in the Japanese Society for Hypothalamic and Pituitary Tumors [0.03%]
日本下丘脑和垂体肿瘤协会中的性别分布(会员、领导及会议参与度)
Naoko Inoshita,Noriko Makita,Takayuki Matsuo et al.
Naoko Inoshita et al.
Gender equity has become an important issue in academic medicine, but data on gender distribution in subspecialty medical societies remain limited. We analyzed gender distribution in membership, leadership positions, and conference particip...
Real-world optimization of cutoff values for enzyme immunoassay-based plasma-free fractionated metanephrines for the diagnosis of pheochromocytoma and paraganglioma: a multicenter retrospective study [0.03%]
基于酶联免疫吸附试验的血浆游离分馏代谢肾上腺素类物质诊断嗜铬细胞瘤和副神经节瘤截断值的多中心回顾性研究优化
Masato Yonamine,Ryota Ishii,Katsutoshi Takahashi et al.
Masato Yonamine et al.
Pheochromocytoma and paraganglioma (PPGL) require sensitive biochemical screening to prevent delayed or missed diagnoses. In Japan, plasma-free metanephrines (pMN/pNMN) measured using enzyme immunoassay have been covered by national insuran...
Diagnostic criteria for adrenal overt Cushing syndrome: prepared jointly by the Japan Endocrine Society and the Health and Labour Sciences Research Grant (Research on Intractable Diseases) Research Group on Disorders of Adrenal Hormones [0.03%]
日本内分泌学会与劳动科学研究中心（难治性疾病的研究所补助研究基金会：肾上腺激素异常研究组）联合制定的库欣病诊断标准
Takuyuki Katabami,Hirotaka Shibata,Akiyo Tanabe et al.
Takuyuki Katabami et al.
Adrenal overt Cushing syndrome (CS) is a rare disease but presents with a high risk of serious, life-threatening complications. Although florid CS is less frequently reported now, the interval between symptom onset and diagnosis still remai...
Teprotumumab-associated persistent unilateral hearing loss in dysthyroid optic neuropathy: a case report with review of the literature [0.03%]
甲状腺眼病患者使用 teprotumumab 治疗后出现持续性单侧听力下降的病例报告及文献回顾
Yuji Hiromatsu,Kumiko Suzuki,Shiho Watanabe et al.
Yuji Hiromatsu et al.
We report a case of severe thyroid eye disease (TED) complicated by dysthyroid optic neuropathy (DON) in a 55-year-old woman with Graves' disease. Despite insufficient response to high-dose intravenous steroid therapy, teprotumumab led to m...
Early diagnosis of capivasertib-associated severe hyperglycemia with diabetic ketosis diagnosed in routine clinical practice: a case report with review of literature [0.03%]
卡博维司特相关重度高血糖及糖尿病酮症的早期诊断——一例常规临床实践中的个案报告及文献回顾
Masashi Yoshikawa,Keiichiro Takahashi,Satoshi Yoshino et al.
Masashi Yoshikawa et al.
Capivasertib, an oral pan-AKT inhibitor, is a therapeutic option for hormone receptor-positive advanced breast cancer. While hyperglycemia is a recognized adverse effect of AKT inhibition, its diagnosis is often delayed in routine clinical ...
Mari Yamamoto,Yuri Mukoyama,Kentaro Kishi et al.
Mari Yamamoto et al.
Cushing's disease (CD) is very rare in children. Nineteen children (≤18 years) with CD (median age at diagnosis: 13 [6-17] years; 12 females) were retrospectively analyzed using medical records (1994-2025) from Toranomon Hospital, Tokyo, J...
Associations of stress hormones, autonomic function, and endothelial function in patients with diabetes [0.03%]
糖尿病患者的应激激素、自主神经功能和内皮细胞功能之间的关系
Takanobu Saheki,Keisuke Takahashi,Eri Harada et al.
Takanobu Saheki et al.
Endothelial dysfunction is an early feature of diabetic vascular injury. Stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis, together with autonomic imbalance, may contribute to endothelial dysfunction. However, its ...