Association of physical activity and sedentary time with risk of non-alcoholic fatty liver disease in adults with and without diabetes mellitus [0.03%]
不同糖尿病状态成年人运动时间和久坐时间与非酒精性脂肪肝发病风险的关联研究
Yulin Zheng,Yi Wang,Lili Zhang et al.
Yulin Zheng et al.
This study examined the association of physical activity (PA) and sedentary time (ST) with the risk of non-alcoholic fatty liver disease (NAFLD) in adults with and without diabetes mellitus (DM). The study used data from the 2017-2020 Natio...
A case of prolonged adrenal insufficiency following osilodrostat discontinuation with a review of the literature [0.03%]
柳螺ドロstat停药后出现肾上腺功能不全1例及文献回顾
Sonia Kaniuka-Jakubowska,Michał Kunc,Maria Maksymowicz et al.
Sonia Kaniuka-Jakubowska et al.
Osilodrostat is an oral steroidogenesis inhibitor used in the treatment of hypercortisolism. It works by inhibiting 11-beta-hydroxylase, a key enzyme in cortisol synthesis. As a consequence of drug action, adrenal insufficiency can be obser...
Effects of maternal commercial supplementation on 25-hydroxyvitamin D levels in newborns: a retrospective cohort study in a single center, Saitama, Japan, 2022-2023 [0.03%]
日本埼玉单中心2022-2023年产妇商业补充维生素D对新生儿25-羟基维生素D水平影响的回顾性队列研究
Kazumi Morisawa,Kazushige Ikeda,Mariko Hida et al.
Kazumi Morisawa et al.
Vitamin D (VD) insufficiency in pregnant women is a serious health problem worldwide. To prevent VD insufficiency during pregnancy, several guidelines recommend 600 IU/day VD for all pregnant women. In Japan, no national guidelines for prev...
Masahiro Okano,Teruki Miyake,Shinya Furukawa et al.
Masahiro Okano et al.
A high body mass index (BMI) is associated with the onset of diabetes mellitus (DM). However, evidence regarding the association between changes in BMI and DM onset is limited, and the effect of annual BMI (kg/m2/year) change on DM onset is...
Selective β3-adrenoceptor agonist reduces energy intake and elevates GDF15 levels in lean and diet-induced obese mice [0.03%]
选择性β3-肾上腺素受体激动剂可降低摄食量并提高无脂肪质量因子15的水平：在正常体重和饮食诱导的肥胖小鼠中的作用
Arata Mori,Yasuo Oguri,Sho Matsui et al.
Arata Mori et al.
β3-Adrenoceptors (β3ARs) are expressed in the adipose tissue, the brain, and the bladder. In rodents, selective β3AR agonists have been shown to reduce normal chow intake through central and peripheral mechanisms. However, the impact of ...
Sintilimab-related fulminant autoimmune diabetes mellitus manifesting as diabetic ketoacidosis and rare insulin resistance: A case report and literature review [0.03%]
sintilimab相关性急性自身免疫糖尿病致糖尿病酮症酸中毒及罕见的胰岛素抵抗1例报告及文献复习
Junhui Zhang,Yuping Zhang,Hongmei Li et al.
Junhui Zhang et al.
The incidence of immune checkpoint inhibitor (ICI)-induced type 1 diabetes mellitus (ICI-T1DM) has increased as the use of ICIs has increased. Autoimmune ICI-T1DM often presents as diabetic ketoacidosis, resulting from insulin deficiency, a...
Japan Endocrine Society Clinical Practice Guideline for the Diagnosis and Management of Pheochromocytoma and Paraganglioma 2025 [0.03%]
日本内分泌学会2025年嗜铬细胞瘤和副神经节瘤诊断和管理临床实践指南
Akiyo Tanabe,Takuyuki Katabami,Shigeatsu Hashimoto et al.
Akiyo Tanabe et al.
Pheochromocytomas and paragangliomas are characterized by two key features: endocrine disorders with excessive catecholamine secretion and a hereditary or metastatic nature, making early diagnosis and treatment crucial. This clinical practi...
GPR75 signaling is dispensable for reproduction but contributes to feeding and body growth in rats on normal chow and is involved in high-fat diet-induced hyperphagia, obesity, and hyperglycemia development [0.03%]
GPR75信号在大鼠繁殖中可有可无，但其参与正常饲料摄入、机体生长的调节并参与高脂饮食诱导的过食、肥胖和高血糖发生发展
Yuki Otsuka,Naoko Inoue,Safiullah Hazim et al.
Yuki Otsuka et al.
GPR75 has emerged as a therapeutic target for obesity following the discovery of a causal relationship between GPR75 variants and reduced body mass index in humans. Herein, we examined whether GPR75 is dispensable for normal feeding, body g...
Medullary thyroid carcinoma exclusively associated with a homozygous RET V778I pathogenic variant: a case report with review of literature [0.03%]
异ogenous RET V778I致病突变相关的纯合子性髓样甲状腺癌一例及文献复习
Minoru Kihara,Akira Miyauchi,Takashi Akamizu
Minoru Kihara
Medullary thyroid carcinoma (MTC) can occur sporadically or as a hereditary disease. The latter often presents with a multiple endocrine neoplasia type 2 (MEN2) phenotype and is caused by germline-activating pathogenic variants in the RET p...
Distribution of blood pressure and its positive association with body mass index standard deviation score in pediatric patients with X-linked hypophosphatemia: a sub-group analysis from the SUNFLOWER observational study [0.03%]
儿童X连锁低磷血症患者血压分布及其与体质指数标准差评分的正相关性：来自SUNFLOWER观察研究的亚组分析结果
Kaori Fujiwara,Daijiro Kabata,Ryota Kawai et al.
Kaori Fujiwara et al.
Few studies have investigated the distribution of blood pressure (BP) and associated factors in pediatric patients with X-linked hypophosphatemic rickets (XLH). We analyzed snapshot baseline data from the SUNFLOWER study, a longitudinal obs...