Age-related changes in thyroid hormone profile in pediatric patients with Down syndrome [0.03%]
儿童唐氏综合征患者甲状腺激素谱的年龄相关变化
Machiko Toki,Satoshi Narumi,Junko Hanakawa et al.
Machiko Toki et al.
Children with Down syndrome (DS) have a high prevalence of thyroid dysfunction; however, age-related changes in thyroid hormone profiles remain unclear. We investigated the age-related changes in thyroid function in children with DS. We ret...
Dietary fiber density as an important modifying factor in the association between rice intake and obesity in Japanese type 2 diabetes outpatients: a sex and age-stratified cross-sectional investigation (JDDM 80) [0.03%]
日本2型糖尿病门诊患者中膳食纤维密度为大米摄入和肥胖相关性的重要修饰因子：分性别和年龄的横断面研究（JDDM 80）
Efrem d&#x;Avila Ferreira,Mariko Hatta,Laymon Khin et al.
Efrem d&#x;Avila Ferreira et al.
A meta-analysis of cohort studies found a positive association between white rice consumption and chronic disease risk, particularly in women. However, the association between rice intake and obesity remains inconsistent across populations....
Efficacy and safety of once-weekly somatrogon following up to 4 years of treatment in Japanese children with growth hormone deficiency: results from an open-label extension of a phase 3 study [0.03%]
一项针对日本生长激素缺乏儿童为期长达4年治疗的一周一次somatrogon疗效和安全性研究：III期临床试验开放标签延长试验结果
Reiko Horikawa,Toshiaki Tanaka,Yukihiro Hasegawa et al.
Reiko Horikawa et al.
Somatrogon is a long-acting recombinant human growth hormone approved in several countries, including Japan, for the treatment of children with growth hormone deficiency (GHD). In this study (Clinicaltrials.gov:NCT03874013) Japanese patient...
Association of physical activity and sedentary time with risk of non-alcoholic fatty liver disease in adults with and without diabetes mellitus [0.03%]
不同糖尿病状态成年人运动时间和久坐时间与非酒精性脂肪肝发病风险的关联研究
Yulin Zheng,Yi Wang,Lili Zhang et al.
Yulin Zheng et al.
This study examined the association of physical activity (PA) and sedentary time (ST) with the risk of non-alcoholic fatty liver disease (NAFLD) in adults with and without diabetes mellitus (DM). The study used data from the 2017-2020 Natio...
A case of prolonged adrenal insufficiency following osilodrostat discontinuation with a review of the literature [0.03%]
柳螺ドロstat停药后出现肾上腺功能不全1例及文献回顾
Sonia Kaniuka-Jakubowska,Michał Kunc,Maria Maksymowicz et al.
Sonia Kaniuka-Jakubowska et al.
Osilodrostat is an oral steroidogenesis inhibitor used in the treatment of hypercortisolism. It works by inhibiting 11-beta-hydroxylase, a key enzyme in cortisol synthesis. As a consequence of drug action, adrenal insufficiency can be obser...
Effects of maternal commercial supplementation on 25-hydroxyvitamin D levels in newborns: a retrospective cohort study in a single center, Saitama, Japan, 2022-2023 [0.03%]
日本埼玉单中心2022-2023年产妇商业补充维生素D对新生儿25-羟基维生素D水平影响的回顾性队列研究
Kazumi Morisawa,Kazushige Ikeda,Mariko Hida et al.
Kazumi Morisawa et al.
Vitamin D (VD) insufficiency in pregnant women is a serious health problem worldwide. To prevent VD insufficiency during pregnancy, several guidelines recommend 600 IU/day VD for all pregnant women. In Japan, no national guidelines for prev...
Masahiro Okano,Teruki Miyake,Shinya Furukawa et al.
Masahiro Okano et al.
A high body mass index (BMI) is associated with the onset of diabetes mellitus (DM). However, evidence regarding the association between changes in BMI and DM onset is limited, and the effect of annual BMI (kg/m2/year) change on DM onset is...
Selective β3-adrenoceptor agonist reduces energy intake and elevates GDF15 levels in lean and diet-induced obese mice [0.03%]
选择性β3-肾上腺素受体激动剂可降低摄食量并提高无脂肪质量因子15的水平：在正常体重和饮食诱导的肥胖小鼠中的作用
Arata Mori,Yasuo Oguri,Sho Matsui et al.
Arata Mori et al.
β3-Adrenoceptors (β3ARs) are expressed in the adipose tissue, the brain, and the bladder. In rodents, selective β3AR agonists have been shown to reduce normal chow intake through central and peripheral mechanisms. However, the impact of ...
Sintilimab-related fulminant autoimmune diabetes mellitus manifesting as diabetic ketoacidosis and rare insulin resistance: A case report and literature review [0.03%]
sintilimab相关性急性自身免疫糖尿病致糖尿病酮症酸中毒及罕见的胰岛素抵抗1例报告及文献复习
Junhui Zhang,Yuping Zhang,Hongmei Li et al.
Junhui Zhang et al.
The incidence of immune checkpoint inhibitor (ICI)-induced type 1 diabetes mellitus (ICI-T1DM) has increased as the use of ICIs has increased. Autoimmune ICI-T1DM often presents as diabetic ketoacidosis, resulting from insulin deficiency, a...
Japan Endocrine Society Clinical Practice Guideline for the Diagnosis and Management of Pheochromocytoma and Paraganglioma 2025 [0.03%]
日本内分泌学会2025年嗜铬细胞瘤和副神经节瘤诊断和管理临床实践指南
Akiyo Tanabe,Takuyuki Katabami,Shigeatsu Hashimoto et al.
Akiyo Tanabe et al.
Pheochromocytomas and paragangliomas are characterized by two key features: endocrine disorders with excessive catecholamine secretion and a hereditary or metastatic nature, making early diagnosis and treatment crucial. This clinical practi...