HIF-1α stabilization in osteoclasts induces the expression of aerobic glycolysis-related proteins GLUT1, LDHA, and MCT4 [0.03%]
缺氧诱导因子HIF-1α在破骨细胞中的稳定促进葡萄糖转运蛋白GLUT1、乳酸脱氢酶LDHA及单羧酸转运体MCT4的表达
Tsuyoshi Nishioku,Sae Nakao,Rumi Anzai et al.
Tsuyoshi Nishioku et al.
Hypoxia-inducible factor (HIF)-1α is a master transcription factor regulating hypoxic adaptation and activates the transcription of genes involved in various steps of energy metabolism. However, some subsets of cancer cells exhibit high HI...
Improved serotonin neuron-specific viral vectors applicable for optogenetic manipulation and recording [0.03%]
一种改进的可用于光学操控和记录的五型腺病毒文库及其应用
Takuma Noguchi,Harune Hori,Koji Toda et al.
Takuma Noguchi et al.
Serotonin neurons are central to the pathophysiology and therapeutics of mental disorders, including major depressive disorder, anxiety, and schizophrenia. Genetically modified mice make it possible to target serotonin neurons by selective ...
Inhibition of CYP1B1 by miR-200b-3p increases the sensitivity of paclitaxel in hepatocellular carcinoma treatment [0.03%]
miR-200b-3p通过抑制CYP1B1提高肝癌细胞对紫杉醇的敏感性
Jiaqi Wang,Jiayi Wu,Haihong Hu et al.
Jiaqi Wang et al.
Liver cancer ranks as the third leading cause of cancer-related death worldwide, with hepatocellular carcinoma (HCC) accounting for approximately 90 % of primary liver cancer cases. Elevated expression of drug-metabolizing enzyme CYP1B1 in ...
Targeting CD38 to alleviate brain endothelial cell dysfunction and cognitive impairment in vascular dementia [0.03%]
靶向CD38缓解血管性痴呆中的脑内皮细胞功能障碍和认知障碍
Mingjing Yu,Zhi Qi,Jiaxin Zhang et al.
Mingjing Yu et al.
Vascular dementia (VaD) is a leading cause of cognitive decline, closely associated with cerebrovascular endothelial cell (CEC) dysfunction, blood-brain barrier (BBB) disruption, and neuroinflammation. CD38, an enzyme implicated in neuroinf...
Exposure of Zinc-induced Parkinson's disease-like non-motor and motor symptoms in relation to oxidative/nitrosative stress mediated neurodegeneration in the brain of Drosophila melanogaster [0.03%]
锌诱导的帕金森病样非运动和运动症状与黑腹果蝇大脑中的氧化/硝基化压力介导的神经退行性变的关系研究
Abhishek P R Nadiga,K L Krishna,Afrasim Moin et al.
Abhishek P R Nadiga et al.
Parkinson's disease (PD) is the second most prevalent idiopathic neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to locomotor impairment. Despite extensive researc...
Tomatidine attenuates post-stroke cognitive impairment by reducing neuroinflammation through prevention of M1 microglial polarization via NF-κB signaling [0.03%]
番茄胺通过NF-κB信号抑制M1型小胶质细胞极化减轻神经炎症并改善卒中后认知障碍
Ayami Kita,Yuka Kawade,Haruyoshi Murakami et al.
Ayami Kita et al.
Post-stroke cognitive impairment (PSCI) is a clinical disorder that commonly occurs after a stroke and may persist long-term in most stroke survivors. Neuroinflammation involving proinflammatory M1 microglia, an activated microglial phenoty...
Ferulic acid suppresses guinea pig ileal longitudinal smooth muscle contractions by inhibiting voltage-dependent Ca2+ channels [0.03%]
丁香酸通过抑制电压门控钙离子通道抑制 Guinea Pig 回肠纵向平滑肌收缩
Keisuke Obara,Kento Yoshioka,Aya Shimada et al.
Keisuke Obara et al.
We investigated the effects of ferulic acid (FA) on contractions in guinea pig ileal longitudinal smooth muscle (ILSM). FA (3 × 10-4-3 × 10-3 M) inhibited ILSM contractions induced by acetylcholine, histamine, prostaglandin F2α, and sero...
Inhibitory effects of γ-linolenic acid on contractile responses in pig coronary arteries: Possible involvement of prostanoid TP receptor inhibition [0.03%]
γ-亚麻酸对猪冠状动脉收缩反应的抑制作用及可能涉及的前列腺素TP受体抑制作用
Keisuke Obara,Kento Yoshioka,Mikoto Ozawa et al.
Keisuke Obara et al.
We examined whether γ-linolenic acid (GLA), an n-6 polyunsaturated fatty acid (PUFA) and a structural isomer of α-linolenic acid (an n-3 PUFA), inhibited contractions of isolated pig coronary arteries. GLA potently inhibited the contracti...
Pedunculoside regulates the differentiation of neural stem cells into neurons via the PI3K/AKT/GSK-3β pathway [0.03%]
Pedunculoside通过PI3K/AKT/GSK-3β信号通路调节神经干细胞向神经元分化
Ruichen Jiang,Yuming Wang,Yanzhu Shen et al.
Ruichen Jiang et al.
The aging population has increased neurodegenerative diseases, yet current therapies mostly relieve symptoms rather than halt disease progression. Neural stem cells (NSCs) are crucial in nervous system development and repair, and research o...
A selective eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood glucose in Zucker fatty diabetes mellitus rat [0.03%]
选择性真核生物延长因子2激酶抑制剂A484954可降低 Zucker 糖尿病大鼠血糖水平
Ko Adachi,Tomoko Kodama,Kosuke Otani et al.
Ko Adachi et al.
Eukaryotic elongation factor 2 kinase (eEF2K) is a protein kinase, regulating peptide translation. Zucker fatty diabetes mellitus (ZFDM) rat is a recently developed obesity and type 2 diabetes animal model with a missense mutation (fa) in l...