Functional characterization of human organic anion transporter 4 (hOAT4) as a pH-dependent citrate transporter in renal proximal tubules [0.03%]
Yuki Ikematsu,Nattavadee Pengrattanachot,Yoshie Reien et al.
Yuki Ikematsu et al.
Citrate plays a crucial role in preventing calcium stone formation by chelating calcium and inhibiting crystal aggregation. Organic anion transporters (OATs), expressed in renal proximal tubules, mediate the transport of various organic ani...
Ameliorative effect of sea cucumber on physical fatigue induced by forced ambulation and its underlying mechanism [0.03%]
Osamu Nakagawasai,Kotaro Yamada,Kohei Takahashi et al.
Osamu Nakagawasai et al.
Fatigue represents a significant health concern. Chronic fatigue may contribute to mental health disorders and accelerated aging. Oxidative stress, characterized by excessive production of reactive oxygen species, is generally considered to...
Effect of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptor antagonist, in guinea pig models of allergic rhinitis [0.03%]
Akihiro Kamiya,Tomohiko Sekioka,Masabumi Minami
Akihiro Kamiya
This study evaluated the anti-rhinitic effects of ONO-6950, a novel dual antagonist of cysteinyl leukotriene 1 (CysLT1) and 2 (CysLT2) receptors, in guinea pig models of allergic rhinitis. First, in a conventional allergic rhinitis model wi...
Modulation of age-associated immune dysfunction and allergic responses by Mongolian Lycium ruthenicum extract in murine models [0.03%]
蒙古地菍提取物调节小鼠年龄相关免疫功能障碍和过敏反应
Mao Kaneki,Chiharu Ohira,Chizuki Usui et al.
Mao Kaneki et al.
Background: Lycium ruthenicum (black goji berry) is rich in anthocyanins and proanthocyanidins with potent antioxidant and anti-inflammatory activities. This study evaluated whether Mongolian L. ruthenicum (LR) extract mo...
Sodium-glucose Co-transporter 2 (SGLT2) inhibitor dapagliflozin acutely activates cardiomyocyte HIF-1α signaling via succinate, a signaling metabolite [0.03%]
钠-葡萄糖共转运蛋白2抑制剂达格列净通过信号代谢物琥珀酸急性激活心肌细胞HIF-1α信号通路
Tatsuyuki Sato,Takayuki Isagawa,Yuki Sugiura et al.
Tatsuyuki Sato et al.
SGLT2 inhibitors are widely used to treat patients with chronic heart failure, and several studies have shown that the efficacy of SGLT2 inhibitors also extends to acute heart failure. However, the mechanisms remain unknown. Here, using kno...
Ferulic acid activates Nrf2/HO-1 signaling axis to ameliorate neuronal Golgi stress by SKP2 [0.03%]
富马酸通过SKP2激活Nrf2/HO-1信号轴改善神经元高尔基应激
Qinghua Dong,Chao Liu,Aiguo Li et al.
Qinghua Dong et al.
Background: Traumatic brain injury (TBI) ranks among the top contributors to neurological impairments worldwide, with Golgi stress implicated in neuronal injury. This study investigated the neuroprotective effects of feru...
Protective effects of a highly water-soluble rutin on cognitive dysfunction in mice [0.03%]
一种高水溶性芸香苷对认知障碍小鼠的保护作用
Honoka Fujimori,Takuya Ohba,Yoshiki Kuse et al.
Honoka Fujimori et al.
Dementia involves progressive cognitive decline, impairing daily and social activities. As no current drugs can reverse this decline, preventive strategies using functional compounds are gaining attention. Rutin, a flavonoid with neuroprote...
Therapeutic effects of fingolimod through sphingosine-1-phosphate signaling in pulmonary arterial hypertension [0.03%]
fingolimod通过鞘氨醇-1-磷酸信号通路治疗肺动脉高压的效果
Moe Fujiwara,Aya Yamamura,Rubii Kondo et al.
Moe Fujiwara et al.
Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease characterized by pulmonary vascular remodeling. This remodeling is primarily caused by abnormal proliferation of pulmonary arterial smooth muscle cells (PAS...
Deep learning deciphers behavioral states from muscle activation patterns [0.03%]
深度学习从肌肉激活模式中解析行为状态
Honoka Kuroyanagi,Yuji Ikegaya,Nobuyoshi Matsumoto
Honoka Kuroyanagi
Accurate assessment of animal behavior is limited by manual video observation. Here, we demonstrate that deep learning-based analysis of multi-site electromyograms enables classification of behavioral states. Electromyograms were recorded f...
Postoperative administration of 2,5-dimethylcelecoxib attenuates ischemia-reperfusion injury-induced cardiac dysfunction [0.03%]
术后服用2,5-二甲基塞乐西布可减轻缺血再灌注损伤引起的心功能障碍
Shin Ishikane,Takehiro Kishigami,Eigo Ikushima et al.
Shin Ishikane et al.
Ischemia-reperfusion (I/R) following reperfusion therapy for ischemic heart disease is a driver of adverse cardiac remodeling and eventual heart failure. We investigated the therapeutic potential of 2,5-dimethylelcelecoxib (DM-C) to prevent...