Cholinesterase activity determines the action potential-dependent increase in glycine receptor-mediated inhibitory synaptic transmission in the substantia gelatinosa of the spinal trigeminal nucleus of the rat [0.03%]
乙酰胆碱酯酶活性决定胆碱能神经元对三叉脊核凝胶状 Substance P 依赖的抑制性突触传递的增加作用
Masahito Kawamura Jr,Eiji Masaki,Fusao Kato
Masahito Kawamura Jr
Acetylcholine-mediated modulation of pain-associated behaviors has been progressively well described. The mechanisms of cholinergic antinociception have been reported to involve the activation of nAChRs or mAChRs modulating GABAergic and/or...
Establishment of spinocerebellar ataxia type 34 model mice accompanied by early glial activation and degeneration of cerebellar neurons [0.03%]
伴早期胶质细胞活化和小脑神经元退行性变的第三十四型脊小脑共济失调模型小鼠的建立
Yuri Morikawa-Yujiri,Kensuke Motomura,Ayumu Konno et al.
Yuri Morikawa-Yujiri et al.
Spinocerebellar ataxia type 34 (SCA34) is an autosomal dominant neurodegenerative disease primarily characterized by progressive cerebellar atrophy and ataxia, frequently accompanied by cognitive dysfunction and erythrokeratodermia variabil...
Changes in the orexin system, hypothalamic-pituitary-adrenal axis and circadian rhythm in juvenile-stressed rats [0.03%]
幼年应激大鼠下丘脑觉醒系统、下丘脑-垂体-肾上腺轴及昼夜节律的改变
Kazune Ozaki,Shinya Nishiide,Hiroki Shikanai et al.
Kazune Ozaki et al.
The orexin system has been demonstrated to play various physiological roles, such as in feeding, sleep, and autonomic neural function. Clinically, orexin receptor antagonists are used as hypnotics, and several clinical trials have suggested...
Myricetin inhibits vascular calcification in an in vitro model by modulating ferroptosis-related SLC7A11/GPX4 signaling [0.03%]
芦丁通过调节铁死亡相关SLC7A11 / GPX4信号抑制体外血管钙化
Taeyeon Kim,Eun-Nam Kim,So-Hyung Kwak et al.
Taeyeon Kim et al.
Vascular calcification (VC) is a major complication of type 2 diabetes mellitus (T2DM) and is associated with increased cardiovascular risk. Myricetin, a natural flavonoid with reported cardiovascular protective properties, has not been ful...
Enhanced effect of the hallucinogen DOI in L-DOPA receptor Gpr143-deficient mice [0.03%]
L-多巴受体Gpr143缺陷型小鼠中致幻剂DOI的增强效应
Daiki Masukawa,Rei Tajika,Yoshimi Ichimaru et al.
Daiki Masukawa et al.
Hallucinogens, such as lysergic acid diethylamide, act primarily through the 5-hydroxytryptamine 2A (5-HT2A) receptor, but their regulatory mechanisms remain unclear. G protein-coupled receptor 143 (GPR143), an L-3,4-dihydroxyphenylalanine ...
Minocycline inhibits endothelin-1-induced contraction in isolated pulmonary artery [0.03%]
米诺环素抑制内皮素-1诱导的孤立肺动脉收缩
Ryo Niijima,Kosuke Otani,Tomoko Kodama et al.
Ryo Niijima et al.
Pulmonary hypertension (PH) still requires both elucidation of pathological mechanisms and development of new treatment agents. We previously reported that an intraperitoneal administration of minocycline prevented monocrotaline-induced PH ...
Viral infection and establishing new therapeutic platforms- On the occasion of receiving the 16th Setsuro Ebashi award [0.03%]
病毒感染与建立新的治疗平台——获得第十六届江崎玲于奈纪念奖的感想
Yumiko Imai
Yumiko Imai
During the past quarter century, a series of global pandemics-caused by coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2) and influenza A (H1N1, H5N1)-has underscored that viral infection is not merely a transient invasion but a systemic and t...
Functional characterization of human organic anion transporter 4 (hOAT4) as a pH-dependent citrate transporter in renal proximal tubules [0.03%]
人源有机阴离子转运蛋白4（hOAT4）的功能表征：作为肾近端小管中的PH依赖性柠檬酸盐转运蛋白
Yuki Ikematsu,Nattavadee Pengrattanachot,Yoshie Reien et al.
Yuki Ikematsu et al.
Citrate plays a crucial role in preventing calcium stone formation by chelating calcium and inhibiting crystal aggregation. Organic anion transporters (OATs), expressed in renal proximal tubules, mediate the transport of various organic ani...
Ameliorative effect of sea cucumber on physical fatigue induced by forced ambulation and its underlying mechanism [0.03%]
刺参对强行负重致疲劳小鼠的改善作用及机制研究
Osamu Nakagawasai,Kotaro Yamada,Kohei Takahashi et al.
Osamu Nakagawasai et al.
Fatigue represents a significant health concern. Chronic fatigue may contribute to mental health disorders and accelerated aging. Oxidative stress, characterized by excessive production of reactive oxygen species, is generally considered to...
Effect of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptor antagonist, in guinea pig models of allergic rhinitis [0.03%]
新型白三烯受体拮抗剂ONO-6950对过敏性鼻炎豚鼠模型的作用研究
Akihiro Kamiya,Tomohiko Sekioka,Masabumi Minami
Akihiro Kamiya
This study evaluated the anti-rhinitic effects of ONO-6950, a novel dual antagonist of cysteinyl leukotriene 1 (CysLT1) and 2 (CysLT2) receptors, in guinea pig models of allergic rhinitis. First, in a conventional allergic rhinitis model wi...