Formalizing and expanding our ethical framework: Introducing the comprehensive ethical guidelines for the Journal of Pharmacological Sciences [0.03%]
伦理框架的完善与扩充——《药理学杂志》全面伦理准则的制定
Junko Kurokawa,Yuji Ikegaya,Tomoyuki Furuyashiki et al.
Junko Kurokawa et al.
Phenylalanine amide derivatives promote FLG expression via AHR activation in normal human epidermal keratinocytes [0.03%]
苯基胺衍生物通过激活正常人类表皮角质形成细胞中的AHR促进FLG表达
Akiko Sumitomo,Ratklao Siriwach,Makio Higuchi et al.
Akiko Sumitomo et al.
Filaggrin (FLG) is one of the major components expressed in terminally differentiated keratinocytes and critical for skin barrier functions. It is known that reduced FLG expression causes skin barrier dysfunctions and results in atopic derm...
TPNA10168, an Nrf2 activator, attenuates LPS-induced inflammation in microglia through modulation of MAPK and NF-κB pathways [0.03%]
Nrf2激活剂TPNA10168通过调节MAPK和NF-κB通路缓解LPS诱导的微胶质细胞炎症
Yasuhiko Izumi,Eri Koide,Fumika Kobayashi et al.
Yasuhiko Izumi et al.
The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway is a major cellular defense mechanism against oxidative stress through the induction of antioxidant proteins. Chemical inducers of Nrf2 often ...
SMTP-44D prevents negative symptoms of diabetic neuropathy by inhibiting sciatic nerve apoptosis [0.03%]
SMTP-44D通过抑制坐骨神经凋亡来预防糖尿病性神经病的阴性症状
Ayaka Aoki,Keita Shibata,Ryosuke Shinouchi et al.
Ayaka Aoki et al.
Diabetic neuropathy (DN) affects more than 50 % of patients with diabetes mellitus (DM). With progression, it causes negative symptoms characterized by sensory numbness. However, no effective treatment drug has been approved for the negativ...
Naoaki Sakamoto,Masahiro Fukuda,Yusuke Miyazaki et al.
Naoaki Sakamoto et al.
Rodent rearing behavior is frequently assessed as an indicator of anxiety and exploratory tendencies. This study developed a convolutional recurrent neural network (CRNN) model to detect mouse rearing using overhead videos. Behavioral data ...
Medial prefrontal cortex inputs to the dorsomedial striatum regulate motivation for wheel running in male mice [0.03%]
雄性小鼠中前额叶皮质输入背内侧纹状体调节跑步动机
Kazuhei Niitani,Ryoma Nishida,Yu Ogura et al.
Kazuhei Niitani et al.
Wheel running is rewarding for rodents, and thus they exhibit strong willingness to engage in it and desire for it, i.e., motivation. Although neural activity in the dorsomedial striatum (DM-Str) has been suggested to be involved in motivat...
Oral administration of undenatured type II collagen significantly inhibits arthritis-associated pain signal in a mouse model of collagen antibody-induced arthritis and meniscus removal [0.03%]
口服未变性II型胶原蛋白可显著抑制Collabor抗体诱导的关节炎小鼠模型和半月板切除相关的疼痛信号通路
Ibuki Yasuda,Mao Kaneki,Chiharu Ohira et al.
Ibuki Yasuda et al.
Osteoarthritis (OA) is joint pain caused by persistent low-grade inflammation, and is characterized by bone remodeling, synovitis, and articular cartilage degeneration. This study focused on undenatured type II collagen (UC-II®) and examin...
Additive effects of mirabegron on muscarinic receptor binding and on relaxation of cholinergic detrusor muscle contraction by antimuscarinics [0.03%]
Mirabegron对毒蕈碱受体结合及抗胆碱药物舒张逼尿肌收缩的增效作用
Shizuo Yamada,Masae Mochizuki,Kana Maruyama-Fumoto et al.
Shizuo Yamada et al.
Mirabegron is the first selective β3-adrenoceptor agonist, to be developed as an alternative to antimuscarinic therapy for patients with overactive bladder (OAB). This agent exerts off-target effects on muscarinic receptors. Its combinatio...
Novel PDE9 inhibitors, KR39526 and KR39582, attenuate cardiac hypertrophy and fibrosis induced by pressure overload [0.03%]
新型PDE9抑制剂KR39526和KR39582可减轻压力超负荷诱导的心肌肥大及纤维化
Jeong Hyun Lee,Hyunjin Park,Seung Hyeong Lee et al.
Jeong Hyun Lee et al.
The natriuretic peptide and cyclic guanosine monophosphate (cGMP) cascade are promising therapeutic target for heart failure. This study evaluated the pharmacological properties and cardioprotective effects of novel phosphodiesterase 9 (PDE...
Inhibitory effects of schisandrin A on contractions induced by spasmogenic candidates in porcine coronary arteries [0.03%]
舍拉苷A抑制猪冠状动脉痉挛候选药物所致收缩的作用
Qianghaodi Hong,Naho Takazakura,Hideaki Ozawa et al.
Qianghaodi Hong et al.
The inhibitory effects and underlying mechanisms of schisandrin A (SA) on contractions induced by spasmogenic candidates and related chemicals were investigated in porcine coronary arteries (PCAs). SA (10-5-10-4 M) inhibited contractions in...