Sulfasalazine disrupts the interaction between TNFα and TNFR1 thus inhibiting NF-kB signaling activation to promote bone fracture healing [0.03%]
磺胺水杨酸通过破坏TNFα与TNFR1的相互作用抑制NF-κB信号激活来促进骨折愈合
Jingwei Liu,Cheng Qiu,Xiaoxiong Wang et al.
Jingwei Liu et al.
Fracture is a common type of traumas and alternative therapies to boost bone fracture healing is necessary. The aim of this study is to elucidate the role of sulfasalazine in bone fracture healing by using MC3T3-E1 cells in vitro and murine...
Theanine boosts frontal theta and hippocampal beta and gamma oscillations for familiarity in object recognition [0.03%]
茶氨酸增强熟悉性物体识别中的前额θ频段和海马β及γ频段振荡
Kisa Watanabe,Kinjiro Takeda,Takeshi Nagahiro et al.
Kisa Watanabe et al.
Object recognition memory encourages animals to distinguish between new and known objects, supported by neural activity in the hippocampus, prefrontal cortex, and perirhinal cortex. Theanine, a non-proteinogenic amino acid derivative from g...
Direct effects of cigarette smoke extract from heated tobacco products on cardiomyocyte: Comparison with combustible cigarettes [0.03%]
加热不燃烧烟草产品和可燃香烟萃取液的直接心脏毒性作用对比研究
Jumpei Yasuda,Takuya Notomi,Takahiro Horinouchi et al.
Jumpei Yasuda et al.
Smoking of combustible cigarettes is a risk factor for cardiovascular disease. Heated tobacco products (HTPs) have recently increased in use due to their perceived lower toxicity compared with combustible cigarettes, yet their direct effect...
Comparative Study
Journal of pharmacological sciences. 2025 Oct;159(2):94-104. DOI:10.1016/j.jphs.2025.07.007 2025
Therapeutic potential of SMTP-27 in attenuating diabetic nephropathy with anti-inflammatory activity [0.03%]
SMTP-27抗炎作用治疗糖尿病肾病的潜力研究
Keita Shibata,Taiki Awane,Takashi Takaki et al.
Keita Shibata et al.
Diabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD), affecting nearly one-third of CKD patients. As CKD advances, it may progress to end-stage renal disease, necessitating dialysis or transplantation. Hyperglycemia-...
Oren-gedoku-to inhibits calcification of human aortic valve interstitial cells in vitro and aortic valve in spontaneously hypertensive rats in vivo [0.03%]
芦根解毒汤通过体外和体内实验抑制高血压 rat 主动脉瓣间质细胞钙化
Zaiqiang Yu,Shihu Men,Kazuyuki Daitoku et al.
Zaiqiang Yu et al.
Despite being the most common adult heart valve disease in developed countries, no medicinal treatment exists for calcific aortic valve stenosis (CAS). We previously demonstrated that tumor necrosis factor (TNF)-α promotes aortic valve cal...
Ameliorative effects of Kir4.1 channel inhibitors on lipopolysaccharide-induced cognitive impairment via BDNF/TrkB signaling pathway [0.03%]
Kir4.1通道抑制剂通过BDNF/TrkB信号通路改善脂多糖诱导的认知障碍的积极作用
Yuto Ishizaki,Saki Shimizu,Ayana Kusaka et al.
Yuto Ishizaki et al.
Inwardly rectifying potassium 4.1 (Kir4.1) channels are predominantly expressed in astrocytes and considered to be involved in the pathogenesis of brain diseases, including depression and epilepsy. In the present study, we evaluated the eff...
Early temporal suppression of SPARC inhibits oxidative stress, inflammation, and fibrosis in the chronic phase after renal ischemia/reperfusion [0.03%]
早期抑制SPARC可减轻肾缺血再灌注后的慢性期氧化应激、炎症和纤维化损伤
Hiroe Toba,Denan Jin,Shinji Takai
Hiroe Toba
Acute kidney injury is associated with not only high morbidity in the acute phase but also the development of chronic kidney disease (CKD). Recently, we found that suppression of secreted protein acidic and rich in cysteine (SPARC) exhibits...
Lactucin alleviates lipid accumulation via AMPK-mediated autophagy and fatty acid β-oxidation in FFA-induced HepG2 cells [0.03%]
莴苣烃通过AMPK介导的自噬和脂肪酸β氧化缓解FFA诱导的HepG2细胞脂质蓄积作用研究
Xiaoyan Ma,Yilizere Aibaidula,Chunzi Zhang et al.
Xiaoyan Ma et al.
Lactucin is a natural sesquiterpene lactone isolated from Cichorium glandulosum Boiss. et Huet (CG) has unique biological and pharmaceutical properties. This study was designed to investigate the mechanisms by which Lactucin inhibits lipid ...
LncRNA Mir155hg contributes to hippocampal injury in status epilepticus rats through miR-155/Socs1/NF-κΒ signaling axis [0.03%]
长链非编码RNA Mir155hg通过miR-155/Socs1/NF-κB信号轴参与SE大鼠海马损伤
Yangmei Xie,Ming Wang,Binyuan Xu et al.
Yangmei Xie et al.
Background: Neuroinflammation contributes to cognitive deficits in status epilepticus (SE). The lncRNA Mir155hg has been identified as a key regulator of inflammation, but its role in SE remains unclear. ...
Down-regulation of TNF-α/RIPK/Caspase-8 axis by combined infliximab and umbelliferone prevents unilateral ureter ligation-induced interstitial renal fibrosis [0.03%]
联合使用英夫利昔单抗和伞形花内酯通过下调TNF-α/RIPK/Caspase-8轴防止单侧输尿管结扎所致肾间质纤维化
Maha Habash,Zainab H Almansour,Rasha K Al-Akeel et al.
Maha Habash et al.
Obstructive nephropathy is a chronic condition that causes progressive kidney damage due to inflammation, oxidative stress, necroptosis, and fibrosis. The present study aimed to evaluate the potential chemopreventive effect of infliximab (T...