Rho kinase 2 promotes epithelial-mesenchymal transition and proliferation in human prostate cancer PC-3 cells [0.03%]
ROCK2通过促进上皮间质转化及细胞增殖促进前列腺癌PC-3细胞生长
Alamgir Hossain,Aya Yamamura,Md Junayed Nayeem et al.
Alamgir Hossain et al.
Prostate cancer is the second most common cancer in men. Although androgen deprivation therapy is initially effective, resistance inevitably develops. Most patients eventually progress to castration-resistant prostate cancer, a stage with l...
Establishing a nanoluciferase-based assay as a high-throughput screening platform for therapeutics in congenital nephrotic syndrome [0.03%]
建立Nanoluciferase基底测定作为先天性肾病综合征治疗的高通量筛选平台
Haruki Tsuhako,Mary Ann Suico,Haruka Kojima et al.
Haruki Tsuhako et al.
Nephrin is crucial for the formation of the glomerular slit diaphragm, which is the final filtration barrier in the kidney. A mutation in the NPHS1 gene that codes for nephrin causes congenital nephrotic syndrome of the Finnish type (CNF). ...
MicroRNA-3473b regulates corticosterone-induced microglial polarization and inflammation through TREM2 [0.03%]
microRNA-3473b通过TREM2调节皮质酮诱导的小胶质细胞极化和炎症反应
Jingjing Shi,Caina Ma,Yuexi Liu et al.
Jingjing Shi et al.
Microtubule-dependent regulation of TMEM16A-mediated Ca2+-activated Cl- currents in vascular smooth muscle cells [0.03%]
微管依赖的TMEM16A介导血管平滑肌细胞Ca2+激活Cl-电流的调节作用
Ryosuke Hemmi,Akane Suzukawa,Moe Fujiwara et al.
Ryosuke Hemmi et al.
TMEM16A channels mediate Ca2+-activated Cl- (ClCa) currents in vascular smooth muscle cells (VSMCs), and their activity is influenced by cytoskeletal dynamics. The present study examined the functional role of microtubules in TMEM16A regula...
Protective role of orphan G protein-coupled receptor GPR35 in the pathogenesis of colitis through regulating epithelial barrier function and immune responses [0.03%]
孤儿G蛋白偶联受体GPR35通过调节上皮屏障功能和免疫反应在结肠炎发病机制中发挥保护作用
Koga Tokuyama,Hiroyuki Yasuda,Michiko Saito et al.
Koga Tokuyama et al.
Background and objective: GPR35 is involved in the pathogenesis of colitis. However, because GPR35 is expressed in colonic epithelial and inflammatory/immune cells, its precise protective mechanisms remain unclear. We inv...
(2R,6R)-hydroxynorketamine reverses mechanical and thermal pain hypersensitivity produced by the chemotherapeutic agent oxaliplatin in rats [0.03%]
(2R,6R)-羟基诺西莰明逆转了化疗药物奥沙利铂所致大鼠机械和热痛过敏现象
Maria Campanile,Kaitlin Castell,Justin O Pampalone et al.
Maria Campanile et al.
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of a number of anticancer drugs, like oxaliplatin, leading to chronic sensory hypersensitivity and neuropathic pain. This study investigated the effi...
Protocatechuic aldehyde restrains NLRP3 inflammasome activation to alleviate inflammatory response in sepsis [0.03%]
没食子醛通过抑制NLRP3炎性小体的激活来缓解脓毒症中的炎症反应
Yu-Fei Li,Ao Sun,Yang Miao et al.
Yu-Fei Li et al.
Sepsis, a life-threatening organ dysfunction syndrome triggered by infection, is characterized by complex pathophysiology involving dysregulated inflammation, coagulation abnormalities, and mitochondrial dysfunction. Excessive activation of...
TRPV1 antagonist AMG9810 suppresses focal epileptiform discharges and seizures by decreasing extracellular glutamate concentrations in mice [0.03%]
口服TRPV1拮抗剂AMG9810可通过降低外源性谷氨酸浓度来减轻小鼠局灶性癫痫放电和癫痫发作
Hiroshi Moriyama,Hirochika Imoto,Sadahiro Nomura et al.
Hiroshi Moriyama et al.
The development of targeted anti-epilepsy drugs is crucial, as 30 % of patients with epilepsy are resistant to current therapeutics. Transient receptor potential vanilloid 1 (TRPV1) channel antagonists have been demonstrated to suppress dru...
Aprepitant attenuates cutaneous mast cell migration in oxaliplatin-treated mice [0.03%]
阿普瑞坦可减轻奥沙利铂治疗小鼠的皮肤肥大细胞迁移现象
Tsugunobu Andoh
Tsugunobu Andoh
This study investigated whether tachykinin NK1 receptor antagonist aprepitant (APT) inhibits oxaliplatin (OXP)-induced cutaneous mast cell migration in mice. OXP-induced mast cell migration was inhibited by repeated oral administration of A...
Subacute intranasal oxytocin improves neurological recovery after ischemic stroke [0.03%]
急性脑梗死后亚急期内鼻给药催产素可改善神经功能预后
Yusuke Morishita,Youichirou Higashi,Daichi Tani et al.
Yusuke Morishita et al.
Oxytocin (OXT) is a neuropeptide known for its anti-inflammatory and neuroprotective properties; however, its role in post-stroke recovery remains poorly defined. In this study, we investigated whether intranasal OXT administration during t...