Effects of nicotine- and tar-free smoke extracts from combustible cigarettes and heated tobacco products on the function of neutrophil-like HL-60 cells [0.03%]
无尼古丁和焦油的卷烟烟雾提取物及加热烟草制品对类中性粒细胞HL-60细胞功能的影响
Yuichi Mazaki,Soichi Miwa,Ryosuke Shinkai et al.
Yuichi Mazaki et al.
Impaired neutrophil function is thought to increase infection risk associated with smoking. We examined the effects of nicotine- and tar-free cigarette smoke extracts (CSEs) from combustible cigarettes (CCs) and heated tobacco products (HTP...
Astaxanthin suppress ferroptosis through the Akt1-FoxO3a signaling pathway to alleviates brain injury after intracerebral hemorrhage [0.03%]
虾青素通过Akt1-FoxO3a信号通路抑制铁死亡以减轻脑出血后的脑损伤
Jianwen Zhang,Qiuwei Hua,Lun Gao et al.
Jianwen Zhang et al.
Intracerebral hemorrhage is the second most common subtype of stroke, characterized by high mortality and disability rates. To date, the mechanism of brain injury caused by intracerebral hemorrhage remains unclear, and there are no effectiv...
Effects of imeglimin on mitochondrial functions and ischemic brain damage in young and aging rats [0.03%]
艾明格利敏对年轻及年老大鼠线粒体功能和脑缺血损伤的影响
Evelina Paskeviciene,Kristina Skemiene,Katryna Pampuscenko et al.
Evelina Paskeviciene et al.
Imeglimin, a novel oral antidiabetic drug, has been suggested to affect mitochondrial functions in some types of cells and tissues, however, it has never been investigated whether aging has an impact on its pharmacological effects in the br...
Lutein reduces cisplatin-induced intestinal inflammation by inhibiting ROS-mediated MAPK/NF-κB pathways [0.03%]
叶黄素通过抑制ROS介导的MAPK / NF-κB信号通路减少顺铂引起的肠道炎症反应
Li-King Yang,Leticia B Sy,Ju-Fang Liu et al.
Li-King Yang et al.
Cisplatin is a commonly used chemotherapy drug that can effectively treat a variety of cancers, but it often causes severe side effects, including nephrotoxicity, ototoxicity, and gastrointestinal toxicity, which significantly affects patie...
Uncovering motor impairments in duchenne muscular dystrophy: 24-hour automated behavioral analysis of DBA/2N-mdx mice [0.03%]
自动化行为分析在杜氏肌营养不良DBA/2N-mdx小鼠中发现运动障碍现象
Misato Kida,Yui Kobayashi,Takamasa Numano et al.
Misato Kida et al.
Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder caused by mutations in the dystrophin gene. Although the C57BL/10 background mdx mouse (B10-mdx) model is widely used for DMD research, it presents milder symptoms than...
Class effects of proton pump inhibitors in preventing oxaliplatin-induced peripheral neurotoxicity [0.03%]
质子泵抑制剂预防奥沙利铂所致周围神经毒性作用的类效应分析
Yusuke Mori,Keisuke Mine,Takehiro Kawashiri et al.
Yusuke Mori et al.
Oxaliplatin-induced peripheral neuropathy (OIPN) is a dose-limiting toxicity with limited countermeasures. Basic research has revealed that omeprazole, a proton pump inhibitor (PPI), exerts preventive effects against OIPN. In this study, we...
Histone deacetylase inhibitors suppress retinal angiogenesis by preventing endothelial cell proliferation and accelerating VEGF degradation [0.03%]
组蛋白去乙酰化酶抑制剂通过抑制内皮细胞增殖和加速VEGF降解来抑制视网膜血管生成
Akane Morita,Kanako Takahashi,Naoto Iizuka et al.
Akane Morita et al.
Inhibitors of histone deacetylases (HDACs) suppress retinal angiogenesis by interrupting the vascular endothelial growth factor (VEGF)-mammalian target of rapamycin complex 1 (mTORC1) pathway in proliferating endothelial cells. To investiga...
Endothelial NLRP3-mediated pyroptosis induces blood-brain barrier and neuronal damage in Huntington's disease models [0.03%]
内皮细胞NLRP3介导的焦亡在亨廷顿病模型中诱导血脑屏障和神经元损伤
Jing Cai,Wenshuang Ji,Peng Liu et al.
Jing Cai et al.
The NLRP3 inflammasome is primarily expressed and activated in microglial and endothelial cells. Extensive research has been conducted on the activation of NLRP3 inflammasomes by microglial cells leading to pyroptosis. However, there have b...
Dapagliflozin with losartan but not olmesartan has an add-on protective effect in experimental Alport syndrome [0.03%]
达格列净与洛萨坦而非奥美沙坦在实验性Alport综合征中的附加保护作用
Jun Horizono,Keito Mizumoto,Mary Ann Suico et al.
Jun Horizono et al.
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) and angiotensin receptor blockers (ARBs) each have renoprotective effects in chronic kidney diseases, including Alport syndrome. Here, we investigated the combination of SGLT2i dapaglifloz...
Rosiridin reduces Idiopathic Pulmonary Fibrosis by inhibiting the STAT3/NFκB/SMAD3 signaling pathways [0.03%]
玫瑰醇通过抑制STAT3/NFκB/SMAD3信号途径减少特发性肺纤维化
Yuyao Li,Huili Qi,Haoyue Xu et al.
Yuyao Li et al.
Idiopathic pulmonary fibrosis is a progressive, highly lethal disease with limited treatment options. It is characterized by fibroblast-to-myofibroblast transformation, excessive ECM proliferation and collagen deposition, leading to the des...