RNA-mediated aggregation mechanism of prion-like proteins and its application to drug discovery [0.03%]
RNA介导的朊病毒蛋白类聚集机制及其在药物发现中的应用
Yasushi Yabuki,Norifumi Shioda
Yasushi Yabuki
Neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease are on the rise in super-aging societies. However, the mechanisms underlying the aggregation and propagation of prion-like proteins such as α-synuclein and Tau...
Development of a quantitative gait analysis in an osteoarthritis rat model using machine learning [0.03%]
基于机器学习的骨关节炎模型大鼠步态定量分析系统的建立
Shinya Takenouchi,Takashi Minato,Masahiro Fukuda et al.
Shinya Takenouchi et al.
Quantitative assessment of gait abnormality is essential for osteoarthritis (OA) model. We aimed to establish a low-cost, non-invasive and markerless gait analysis pipeline using machine learning. Rat OA model was induced by intraarticular ...
Acute and chronic effects of imeglimin on peripheral circadian clocks in mice [0.03%]
イメグリミンの急性および慢性投与によるマウス外周時計の影響
Yifan Shi,Pingping Xu,Jun-Ichi Morishige et al.
Yifan Shi et al.
Objective: This study aimed to investigate the acute and chronic effects of imeglimin, a novel antidiabetic agent, on peripheral circadian clocks in mice under a 12-h/12-h light/dark cycle. ...
Clonidine-induced tension changes in guinea pig thoracic aorta: roles of α1L-adrenoceptors, L-type voltage-dependent Ca2+ channels, and K+ channels [0.03%]
克隆底丁所致的 Guinea pig 胸主动脉张力的变化：α1L-肾上腺素受体、L 型电压依赖性钙通道和钾通道的作用
Keisuke Obara,Ryusei Ono,Daiki Kato et al.
Keisuke Obara et al.
We pharmacologically analyzed clonidine-induced tension changes in endothelium-denuded guinea pig thoracic aorta (GP-TA). Clonidine alone produced little change in basal tension; however, in the presence of tetraethylammonium (TEA) or Ba2+,...
Bidirectional effects of orexin receptor antagonists on long-term potentiation in the hippocampus of wild type and Alzheimer's disease model mice [0.03%]
食欲素受体拮抗剂对野生型和阿尔茨海默病模型小鼠海马长期增强的双向作用
Yoshiaki Ohi,Kazuhiro Hada,Yuki Murata et al.
Yoshiaki Ohi et al.
The orexinergic system is dysregulated in patients with Alzheimer's disease (AD). In the present study, we evaluated the effects of chronic administration of dual orexin receptor antagonists, suvorexant (Suv) and lemborexant (Lem), on long-...
Extracellular zinc suppresses microglial inflammatory shift via Zrt- and Irt-related protein 12-dependent uptake [0.03%]
胞外锌通过Zrt和Irt相关蛋白12依赖性摄取抑制小胶质细胞炎症反应转换
Takaaki Aratake,Youichirou Higashi,Takahiro Shimizu et al.
Takaaki Aratake et al.
Microglia exhibit phenotypic plasticity between anti-inflammatory M2 and pro-inflammatory M1 states, and the transition from M2 to M1 is implicated in the progression of acute brain injuries. However, the molecular mechanisms that regulate ...
Male mice recognize male-emitted ultrasonic vocalizations in a two-choice test via oxytocin signaling [0.03%]
雄性小鼠通过催产素信号识别雄性发出的超声波叫声
Tomoya Takemoto,Shotaro Kawano,Rei Endo et al.
Tomoya Takemoto et al.
Social behaviors rely on the integration of multiple sensory cues. Among these, ultrasonic vocalizations (USVs) serve as primary auditory cues in rodents. Although the function of USVs has been extensively studied in pup-female and male-fem...
Spinal dopamine D1/D2 receptor complex stimulates NGF release to activate astrocytes and promote neuropathic pain [0.03%]
脊髓多巴胺D1 / D2受体复合物通过释放NGF激活星形胶质细胞并促进神经病理性疼痛
Yi-Ni Bao,Zi-Meng Zhang,Han Jiang et al.
Yi-Ni Bao et al.
Aims: Blocking peripheral nerve growth factor (NGF) obviously alleviated neuropathic pain, however, the effect and mechanism of spinal NGF in neuropathic pain are remain controversial. This study further investigated the ...
Feasibility of recent peptide therapy for ischemic stroke: a comprehensive exploration [0.03%]
近期肽类治疗缺血性卒中的可行性：系统综述和meta分析
Kuo-Feng Tseng,Kuo-Wei Tseng,Hsien-Yin Liao et al.
Kuo-Feng Tseng et al.
Ischemic stroke is a prominent cause of disability and mortality worldwide, currently no drug therapy is helpful for post-stroke symptoms; thus, there is a need to develop effective treatment strategies. Peptide medication development has a...
TEMPORARY REMOVAL: Development and application of a method for quantitative monitoring of Isepamicin plasma concentration in human plasma based on liquid chromatography-mass spectrometry [0.03%]
基于液相色谱-质谱法的异烟胺人血浆浓度定量检测方法的建立及应用临时删除通知：基于液相色谱-质谱法的异烟胺人血浆浓度定量检测方法的建立及应用
Lili Cui,Yanru Liu,Zhipeng Wang et al.
Lili Cui et al.
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier P...