Modulation of age-associated immune dysfunction and allergic responses by Mongolian Lycium ruthenicum extract in murine models [0.03%]
蒙古地菍提取物调节小鼠年龄相关免疫功能障碍和过敏反应
Mao Kaneki,Chiharu Ohira,Chizuki Usui et al.
Mao Kaneki et al.
Background: Lycium ruthenicum (black goji berry) is rich in anthocyanins and proanthocyanidins with potent antioxidant and anti-inflammatory activities. This study evaluated whether Mongolian L. ruthenicum (LR) extract mo...
Sodium-glucose Co-transporter 2 (SGLT2) inhibitor dapagliflozin acutely activates cardiomyocyte HIF-1α signaling via succinate, a signaling metabolite [0.03%]
钠-葡萄糖共转运蛋白2抑制剂达格列净通过信号代谢物琥珀酸急性激活心肌细胞HIF-1α信号通路
Tatsuyuki Sato,Takayuki Isagawa,Yuki Sugiura et al.
Tatsuyuki Sato et al.
SGLT2 inhibitors are widely used to treat patients with chronic heart failure, and several studies have shown that the efficacy of SGLT2 inhibitors also extends to acute heart failure. However, the mechanisms remain unknown. Here, using kno...
Ferulic acid activates Nrf2/HO-1 signaling axis to ameliorate neuronal Golgi stress by SKP2 [0.03%]
富马酸通过SKP2激活Nrf2/HO-1信号轴改善神经元高尔基应激
Qinghua Dong,Chao Liu,Aiguo Li et al.
Qinghua Dong et al.
Background: Traumatic brain injury (TBI) ranks among the top contributors to neurological impairments worldwide, with Golgi stress implicated in neuronal injury. This study investigated the neuroprotective effects of feru...
Protective effects of a highly water-soluble rutin on cognitive dysfunction in mice [0.03%]
一种高水溶性芸香苷对认知障碍小鼠的保护作用
Honoka Fujimori,Takuya Ohba,Yoshiki Kuse et al.
Honoka Fujimori et al.
Dementia involves progressive cognitive decline, impairing daily and social activities. As no current drugs can reverse this decline, preventive strategies using functional compounds are gaining attention. Rutin, a flavonoid with neuroprote...
Therapeutic effects of fingolimod through sphingosine-1-phosphate signaling in pulmonary arterial hypertension [0.03%]
fingolimod通过鞘氨醇-1-磷酸信号通路治疗肺动脉高压的效果
Moe Fujiwara,Aya Yamamura,Rubii Kondo et al.
Moe Fujiwara et al.
Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease characterized by pulmonary vascular remodeling. This remodeling is primarily caused by abnormal proliferation of pulmonary arterial smooth muscle cells (PAS...
Deep learning deciphers behavioral states from muscle activation patterns [0.03%]
深度学习从肌肉激活模式中解析行为状态
Honoka Kuroyanagi,Yuji Ikegaya,Nobuyoshi Matsumoto
Honoka Kuroyanagi
Accurate assessment of animal behavior is limited by manual video observation. Here, we demonstrate that deep learning-based analysis of multi-site electromyograms enables classification of behavioral states. Electromyograms were recorded f...
Postoperative administration of 2,5-dimethylcelecoxib attenuates ischemia-reperfusion injury-induced cardiac dysfunction [0.03%]
术后服用2,5-二甲基塞乐西布可减轻缺血再灌注损伤引起的心功能障碍
Shin Ishikane,Takehiro Kishigami,Eigo Ikushima et al.
Shin Ishikane et al.
Ischemia-reperfusion (I/R) following reperfusion therapy for ischemic heart disease is a driver of adverse cardiac remodeling and eventual heart failure. We investigated the therapeutic potential of 2,5-dimethylelcelecoxib (DM-C) to prevent...
S-allyl-l-cysteine ameliorates sensorimotor functions after intracerebral hemorrhage in mice concomitantly with prevention of axon tract fragmentation and reduction of brain lesion volume [0.03%]
S-烯丙基-L半胱氨酸通过防止神经纤维轨迹断裂和减少脑梗死体积来改善脑出血后的感觉和运动功能失调
Yuma Hirata,Keita Kinoshita,Keisuke Ushida et al.
Yuma Hirata et al.
Intracerebral hemorrhage (ICH) is a devastating type of stroke with high mortality and limited treatment options. Brain tissue injury featured by neuroinflammation and axonal damage plays a pivotal role in poor outcome. S-allyl-l-cysteine, ...
Protective role of early Tnfsf15 upregulation in limiting glomerular injury and proteinuria in experimental Alport Syndrome [0.03%]
早期Tnfsf15上调在实验性Alport综合征中限制肾小球损伤和蛋白尿的保护作用
Aimi Owaki,Shota Kaseda,Shunsuke Tanigawa et al.
Aimi Owaki et al.
Alport syndrome is a progressive kidney disease caused by pathogenic variants in genes encoding type IV collagen, a major structural component of the glomerular basement membrane (GBM). Abnormal GBM architecture impairs filtration and trigg...
Tacrolimus attenuates Th17 cell-mediated allergic skin inflammation in mice [0.03%]
他克莫司通过抑制Th17细胞减轻小鼠过敏性皮肤炎症反应
Fatemeh Beygom Mirkatouli,Yukiko Tao,Uyanga Enkhbaatar et al.
Fatemeh Beygom Mirkatouli et al.
Tacrolimus, a topical calcineurin inhibitor, is used to treat atopic dermatitis (AD). AD is classically T helper type (Th) 2-driven, but Th17 cells are implicated in chronic AD, yet its efficacy against Th17-dependent pathology remains uncl...