Connexin 43 enhances Bax activation via JNK activation in sunitinib-induced apoptosis in mesothelioma cells [0.03%]
连接素43通过JNK活化增强Bax活化以诱导太阳替尼介导的间皮瘤细胞凋亡
Miaki Uzu,Hiromi Sato,Ayaka Shimizu et al.
Miaki Uzu et al.
The constituent protein of gap junctions, connexin (Cx), interacts with various proteins via its C-terminus region, including kinases, cell-adhesion proteins, and a pro-apoptotic protein, Bax. This molecular interaction may affect expressio...
Takeshi Fujii,Masato Mashimo,Yasuhiro Moriwaki et al.
Takeshi Fujii et al.
T and B cells, macrophages and dendritic cells (DCs) all express most of the components necessary for a functional cholinergic system. This includes choline acetyltransferase (ChAT), muscarinic and nicotinic acetylcholine (ACh) receptors (m...
Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses [0.03%]
Tyrphostin AG类似物抑制H2O2诱导的TRPM2依赖性和非依赖性细胞反应
Shinichiro Yamamoto,Takahiro Toda,Ryo Yonezawa et al.
Shinichiro Yamamoto et al.
Purpose: TRPM2 is a Ca2+-permeable channel that is activated by H2O2. TRPM2-mediated Ca2+ signaling has been implicated in the aggravation of inflammatory diseases. Therefore, the development of TRPM2 inhibitors to preven...
Celastrol inhibits chondrosarcoma proliferation, migration and invasion through suppression CIP2A/c-MYC signaling pathway [0.03%]
雷公藤春碱通过抑制CIP2A/c-Myc信号通路抑制软骨肉瘤的增殖、迁移和侵袭能力
Jinhui Wu,Muchen Ding,Ningfang Mao et al.
Jinhui Wu et al.
Chondrosarcomas (CS) is the second most frequent tumors of cartilage origin. A small compound extracted from Thunder God Vine (Tripterygium wilfordii Hook. F.) called celastrol can directly bound CIP2A protein and effectively inhibit cell p...
Plumbagin suppresses the migration and invasion of glioma cells via downregulation of MMP-2/9 expression and inaction of PI3K/Akt signaling pathway in vitro [0.03%]
.plumbagin通过下调基底细胞癌迁移和侵袭的金属蛋白酶-2/9表达及抑制PI3K/Akt信号途径在体外的作用
Guanghui Chen,Yan Yue,Jun Qin et al.
Guanghui Chen et al.
Plumbagin is a natural naphthoquinone constituent isolated from the roots of medicinal plant Plumbago zeylanica L., and has demonstrated anti-proliferative and anti-invasion activities in various cancer cells. However, its effect on the mig...
Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes [0.03%]
多奈哌齐抑制脑皮质星形胶质细胞培养中缓激肽诱导的胞内钙离子浓度升高作用
Kouki Makitani,Shota Nakagawa,Yasuhiko Izumi et al.
Kouki Makitani et al.
Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease. In the present study, we investigated the responses of astrocytes to bradykinin, an inflammatory mediator, and the effect...
Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice [0.03%]
spleykin酶抑制剂对狼疮性肾炎小鼠的影响
Maki Kitai,Noboru Fukuda,Takahiro Ueno et al.
Maki Kitai et al.
The Fc receptors (FcR) have pivotal roles in the pathogenesis of the autoimmune glomerulonephritis. We therefore investigated the effects of a Syk inhibitor on the progression of lupus nephritis and SH3 domain binding protein 2 and p38MAP k...
Ginsenoside Rg3 exerts anti-depressive effect on an NMDA-treated cell model and a chronic mild stress animal model [0.03%]
Ginsenoside Rg3对NMDA诱导的细胞模型和慢性轻度压力动物模型的抗抑郁作用
Hualin Zhang,Zhongliu Zhou,Ziming Chen et al.
Hualin Zhang et al.
Depression is a common mental disorder and a leading cause of disability. At its most severe, it can lead to suicide. Recently, there has been growing interest in the application of natural herbs for the prevention and treatment of depressi...
Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease [0.03%]
罗利普拉姆改善1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的帕金森病小鼠模型中的情境恐惧消退促进作用
Ken-Ichi Kinoshita,Yoshikage Muroi,Toshihiro Unno et al.
Ken-Ichi Kinoshita et al.
Cognitive impairment often occurs in Parkinson's disease (PD), but the mechanism of onset remains unknown. Recently, we reported that PD model mice produced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show facilitation of hippoca...
Corrigendum to "Human GRIN2B variants in neurodevelopmental disorders" [J Pharmacol Sci 132 (2) 115-121] [0.03%]
“神经发育障碍中的人类GRIN2B变异型”[J Pharmacol Sci 132 (2) 115-121]的勘误项
Chun Hu,Wenjuan Chen,Scott J Myers et al.
Chun Hu et al.
Published Erratum
Journal of pharmacological sciences. 2017 Apr;133(4):280. DOI:10.1016/j.jphs.2017.04.001 2017