Unravelling the effects of specific ingredients of kamishoyosan in reducing aggressive biting behavior in chronically isolated mice to inanimate objects [0.03%]
解 cams 扶正祛邪方中特定成分可减少慢性隔离的小鼠对无生命的物体进行攻击性咬合行为的影响
Kento Igarashi,Satoshi Kuchiiwa,Toshiko Kuchiiwa et al.
Kento Igarashi et al.
Kamishoyosan (KSS) is a well-known traditional Japanese herbal medicine used to treat psychiatric symptoms, such as irritation. We previously reported that KSS decreases mouse aggressive biting behavior (ABB) to inanimate objects using the ...
Non-peptidic natural products that target and modulate oxytocin and arginine vasopressin receptors: Opportunities and challenges [0.03%]
非肽类天然产物作用于和调节催产素和血管加压素受体的机会与挑战
Dane Tregeagle,Catherine Doherty,Timothy Callis et al.
Dane Tregeagle et al.
The ability to target the oxytocin and vasopressin receptors is of high therapeutic value due to their clinical relevance in wide range of neuropsychiatric conditions spanning from anxiety to schizophrenia. Despite the massive therapeutic p...
Centrally administered prostaglandin E2 suppresses the micturition reflex in rats [0.03%]
中枢给予的前列腺素E2可抑制大鼠排尿反射
Takahiro Shimizu,Nobutaka Shimizu,Shun Tsubouchi et al.
Takahiro Shimizu et al.
Prostaglandin E2 (PGE2) facilitates the micturition reflex at the lower urinary tract and spinal cord levels. However, the roles of brain PGE2 in reflex regulation remain unclear. Therefore, we aimed to investigate the effects of intracereb...
Nerol enhances lipid synthesis in human sebocytes via cannabinoid receptor-2-mediated MAPK signaling [0.03%]
nerol通过大麻素受体-2介导的mapk信号促进人类皮脂细胞脂质合成
Qi Zhao,Zhiwei Liu,Yong Wang et al.
Qi Zhao et al.
Purpose: Nerol, a natural monoterpene, is commonly used as a fragrance additive in perfumes and cosmetics due to its pleasant rose-like aromas. Nerol application possesses diverse pharmacological properties, including ant...
Early neuromyelitis optica antibody-induced molecular changes in aquaporin 4 and associated proteins at astrocyte endfeet in murine brain tissues [0.03%]
早期神经脊髓视神经炎抗体诱导的小鼠脑组织星形胶质细胞足突端水通道蛋白4及关联蛋白分子改变
Yumi Yoshikawa,Masaki Tomioka,Yoichiro Abe et al.
Yumi Yoshikawa et al.
Neuromyelitis optica spectrum disorder (NMOSD) is characterized by the production of autoantibodies against aquaporin 4 (AQP4). Because NMOSD progressively causes irreversible and severe neurological damages, understanding the initial molec...
A novel role of celecoxib in the inhibition of calcium-activated chloride channel ANO1 [0.03%]
塞来昔布抑制钙激活的氯通道ANO1的新机制研究
Ping Zhou,Qinqin Li,Xiangyu Li et al.
Ping Zhou et al.
Celecoxib, a non-steroidal anti-inflammatory drug, is widely used in the clinic for its analgesic and anti-inflammatory effects by inhibiting COX-2. Celecoxib also modulates many ion channels including Nav1.5, Kv7 and Kv2.1 channels. Here w...
Ginkgolide B inhibits ferroptosis in PC12 cells and ameliorates the oxidative stress in spinal cord injury through activating Nrf2 signaling pathway [0.03%]
银杏内酯B通过激活Nrf2信号通路抑制PC12细胞铁死亡及脊髓损伤氧化应激反应
Wei She,Wenji Ma,Tongtong Zhang et al.
Wei She et al.
Spinal cord injury (SCI) commonly leads to loss of motor and sensory function and results in huge socioeconomic burden, and it triggers numerous secondary pathological events, including oxidative stress and ferroptosis. This study investiga...
Diurnal variations of neurokinin-1 receptor defines dosing time-dependent differences in antitumor effects of aprepitant in mice [0.03%]
神经激肽1受体的日节律性决定了环苯扎蒂普的给药时间不同其在小鼠抗肿瘤效应不同
Yoshihiro Seto,Shun Tokeshi,Daisuke Inoue et al.
Yoshihiro Seto et al.
Aprepitant, a neurokinin-1 receptor (NK1R) antagonist, has the potential as a novel anticancer agent. This study explored the impact of chronotherapy on the antitumor effect of aprepitant in a mouse model of colorectal carcinoma. Aprepitant...
Rosamultin attenuates cerebral ischemia/reperfusion injury by inhibiting autophagy via the PI3K/Akt/mTOR pathway [0.03%]
玫瑰醇通过PI3K/Akt/mTOR信号通路抑制自噬从而减轻脑缺血再灌注损伤
Hailin Zhang,Baoyuan Zhou,Jixing Liu et al.
Hailin Zhang et al.
Rosamultin (Rosa), a natural small-molecule compound, is known for its protective activity against hypoxia-induced injury, but its role in cerebral ischemic stroke injury remains unclear. To assess Rosa's effects on cerebral ischemic stroke...
Inhibitory effects of ferulic acid on the contraction responses of porcine coronary arteries: a comparison with diltiazem [0.03%]
丁香酸抑制猪冠状动脉收缩作用的实验研究及与地尔硫卓的比较
Kento Yoshioka,Keisuke Obara,Yilin Luo et al.
Kento Yoshioka et al.
Ferulic acid (FA) exerts protective effects against cardiovascular-related diseases; however, its role in coronary artery dilation is unclear. Here, we examined the effects and underlying mechanisms of FA in response to contractions induced...
Comparative Study
Journal of pharmacological sciences. 2025 Jul;158(3):172-181. DOI:10.1016/j.jphs.2025.04.006 2025