Altered flagellin-TLR5 signaling pathway in interaction between host and laboratory Escherichia coli strains engineered for enhanced intestinal colonization in mouse [0.03%]
改良的鞭毛蛋白-TLR5信号通路在宿主与实验室工程肠道埃希氏菌相互作用中的作用
Tsuyoshi Tachibana,Atsushi Minami,Ryutaro Fukui et al.
Tsuyoshi Tachibana et al.
The intestinal microbiota is essential for maintaining intestinal homeostasis by regulating mucosal immune responses. Identifying bacterial traits that support stable host interactions is therefore crucial for developing next-generation muc...
β-Catenin Does Not Co-activate Vitamin D Receptor-mediated Transcription in Osteoblastic and Non-osteoblastic Cells [0.03%]
β-catenin不参与成骨细胞和非成骨细胞维生素D受体介导的转录共激活作用
Tram Thi-Ngoc Nguyen,Yoshiaki Kanemoto,Takahiro Sawada et al.
Tram Thi-Ngoc Nguyen et al.
Vitamin D (VD) and Wnt signaling both play important roles in bone metabolism and are targeted in osteoporosis therapy. Combination treatment with VD derivatives and anti-sclerostin antibodies that activate Wnt signaling improves clinical o...
Total synthesis and stability analysis of natural diacyl-type tuliposides and their non-natural isomers [0.03%]
天然二酰基类风信子皂苷的全合成及稳定性的研究
Yasuo Kato,Kaito Sano,Taiji Nomura
Yasuo Kato
Tuliposides (Pos), major secondary metabolites in tulip, are classified into monoacyl- and diacyl-type compounds. Herein, we report the first total synthesis of naturally occurring diacyl-type PosD and PosF and their isomers diOH-PosD and i...
Secondary metabolites associated with exosome-like nanovesicles from green tea (Camellia sinensis) infusion and the origin of these nanovesicles [0.03%]
源自绿茶（Camellia sinensis）萃取物与次级代谢产物相关的类外泌体纳米囊泡及其来源分析
Manami Monobe,Kaori Ema,Hideki Horie
Manami Monobe
In recent years, there has been increasing evidence that plant-derived vesicles, i.e. exosome-like nanovesicles (ENs), have biological activities. We investigated the ingredients in green tea "Sencha" infusion-derived exosome-like nanovesic...
Influence of melanocortin-4 receptor (mc4r) genome editing on taste and odor components of red sea bream Pagrus major [0.03%]
麦皮黑素受体(mc4r)基因组编辑对红海鱼Pagrus major风味和嗅味成分的影响研究
Hisako Fujiwara,Qiqi Wang,Tomoya Yoshino et al.
Hisako Fujiwara et al.
To investigate the influence of genome editing on the taste and odor of fish meat, we conducted a comparative analysis of taste components, odor components and lipid oxidation index, in the dorsal muscle of mc4r-deficient red sea bream comp...
Metabolomic Profiling of LPS-Induced Systemic Inflammation in Mice: Tryptophan as a Biomarker for Nutritional and Inflammatory Status [0.03%]
脂多糖诱导的小鼠全身炎症的代谢组学特征：色氨酸可作为营养和炎症状态的生物标志物
Rio Kurihara,Yumi Takayama,Riyo Hidaka et al.
Rio Kurihara et al.
LPS-induced inflammation triggers metabolic reprogramming and nutritional decline. This study aimed to identify biomarkers for inflammatory and nutritional stress using GC-MS/MS-based metabolomic profiling. Male mice received LPS to induce ...
Targeting Porphyromonas gingivalis virulence and viability with epimedokoreanin B prevents alveolar bone destruction in vivo [0.03%]
靶向牙龈卟啉单胞菌的毒力和活力的Epimedin C和柯里尔黄酮B防止颌骨破坏
Toru Kariu,Keisuke Nakashima,Tsuyoshi Ikeda
Toru Kariu
Periodontal disease is a major oral infectious condition that leads to the degradation of alveolar bone and subsequent tooth loss. Porphyromonas gingivalis, a keystone pathogen in periodontitis, plays a critical role in disease initiation a...
Tissue-specific and environmental regulation of ascorbate accumulation in the cactus Nopalea cochenillifera [0.03%]
生物活性多肽及蛋白质国际会议摘要集第二部分：论文摘要第二卷：S-Z部分
Qiaochu Wang,Shuusuke Kawachi,Kota Handa et al.
Qiaochu Wang et al.
Cacti are xerophytic plants characterized by water-storing cladodes, thick cuticles, and CAM photosynthesis, enabling high productivity under harsh conditions. They accumulate ascorbate (AsA) at levels comparable to those of leafy vegetable...
Dual-faceted regulation by Butyrophilin 1A1 to produce MUC5AC and IL-8 from human colonic cell line HT29-MTX-E12 [0.03%]
但伊素1A1通过双效调控机制诱导人结肠上皮细胞系HT29-MTX-E12分泌MUC5AC和白介素-8
Minori Ishida,Yuki Kuwana,Mizuki Tsujimoto et al.
Minori Ishida et al.
Butyrophilin subfamily 1 member A1 (BTN1A1) is a major protein of the milk fat globule membrane, but its immunoregulatory function remains largely unresolved, despite its structural similarity to the B7 co-stimulatory molecules. In this stu...
Identification of the biosynthetic gene cluster for PF1451A: Implications for untapped peptide biosynthetic pathways widely distributed in fungi [0.03%]
PF1451A生物合成基因簇的鉴定及其在真菌中广泛分布的未被开发的肽类生物合成途径的意义
Genki Hibi,Taro Ozaki,Riku Sugimoto et al.
Genki Hibi et al.
The biosynthetic gene cluster for PF1451A (1), a potent fungicidal peptide, was identified, showing 1 is a member of ribosomally synthesized and post-translationally modified peptides of fungal origin. Notably, a hypothetical protein belong...