[Characterization of Genetic Polymorphisms Related to 5-FU Metabolizing Enzymes in Japanese Populations] [0.03%]
日本人群氟尿嘧啶代谢酶的遗传多态性研究
Eiji Hishinuma
Eiji Hishinuma
Fluoropyrimidine anticancer agents, exemplified by 5-fluorouracil (5-FU), induce severe adverse effects-such as myelosuppression, emesis, diarrhea, and hand-foot syndrome-in approximately 10-30% of patients. As such toxicities can result in...
[Procedure Validation of Elemental Impurities and Observation in Crude Drugs and Kampo Extracts] [0.03%]
[中药材及汉方制剂中元素杂质检出状况和验证方法探讨]
Mizuki Tomiyasu,Shota Yoshida,Hongyan Zhang et al.
Mizuki Tomiyasu et al.
The General Tests 〈2.66〉 Elemental Impurities section was newly included in the 18th edition of the Japanese Pharmacopoeia to support the transition from the conventional simultaneous control of elements in drug products via colorimetric ...
[Effectiveness of Angiotensin System Inhibitors Against Painful Peripheral Neuropathy in Type 2 Diabetic Old Patients: Validation by Analysis of Pharmacy Claims Data] [0.03%]
血管紧张素系统抑制剂治疗2型老年糖尿病患者周围神经痛有效性的队列研究：利用药物理赔数据验证
Takashi Yamamoto,Tomoyoshi Miyamoto,Shiori Iwane et al.
Takashi Yamamoto et al.
The angiotensin system participates in regulation of neuronal activity in the central and peripheral nervous systems, in addition to its role in the control of cardiovascular functions and fluid balance. A fundamental study employing labora...
Evaluation of the Safety of Lansoprazole Exposure During Early Pregnancy: A Prospective Cohort Study Using Two-Center Counseling Data in Japan [0.03%]
日本两中心咨询数据的前瞻性队列研究评估早期妊娠期兰索拉唑暴露的安全性
Masafumi Hongoh,Izumi Fujioka,Mikako Goto et al.
Masafumi Hongoh et al.
Lansoprazole is a proton pump inhibitor (PPI), frequently used for the treatment of gastroesophageal reflux disease. It may also be used in pregnant women; however, the safety of lansoprazole exposure during pregnancy remains unclear. In th...
[Research and Development Focused on Anti-allergy and Immunomodulatory Drugs Targeting Thymic Stromal Lymphopoietin] [0.03%]
[以胸腺基质淋巴生成素(TSLP)为靶点的抗过敏、免疫调节药物研发]
Noriyasu Hirasawa
Noriyasu Hirasawa
Thymic stromal lymphopoietin (TSLP) is a key cytokine produced primarily by epithelial cells that induces a Th2-type immune response. We have studied the regulation of TSLP production by low-molecular-weight compounds and proposed their use...
[IL-6/STAT3 Signaling Pathways: Molecular Insights and Emerging Thereapeutic Targets] [0.03%]
[白细胞介素-6/信号转导子和转录激活子3信号通路：分子机制及治疗靶点]
Tadashi Matsuda
Tadashi Matsuda
The cytokine interleukin 6 (IL-6) has redundant biological activities in regulating the proliferation, differentiation, and function of various cell types. IL-6 regulates inflammation, immune responses, and hematopoiesis, as well as homeost...
[2-Thiouridine is a Broad-spectrum Antiviral Ribonucleoside Analogue Against Positive-strand RNA Viruses] [0.03%]
[2-硫尿苷是一种针对正链RNA病毒的广谱抗病毒核糖核苷类似物]
Kentaro Uemura
Kentaro Uemura
Emerging and reemerging viral infections, such as the dengue virus (DENV), continue to cause public health concerns, affecting millions of people worldwide annually. The recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ou...
[Neuronal Plasticity-related Mechanisms Triggered by the Transcriptional Coactivator MRTFB, a Regulator for Neuronal Morphology and Gene Expression] [0.03%]
转录共激活因子MRTFB诱导的神经元可塑性相关机制的研究
Daisuke Ihara
Daisuke Ihara
Synaptic plasticity is a key mechanism underlying long-term memory and learning, with proposed associations with altered actin cytoskeleton and gene expression in neurons. Myocardin-related transcription factor (MRTF) family members, abunda...
[Analysis of Plastic Changes in Spinal Neurons in Fibromyalgia and the Exploration of Therapeutic Agents] [0.03%]
fibromyalgia脊髓神经塑形改变分析及其治疗药物探索
Daisuke Uta
Daisuke Uta
Fibromyalgia (FM) is a chronic disorder characterized by widespread pain and various accompanying symptoms, with complex mechanisms involving both peripheral and central nervous systems that remain unclear. Herein, we introduce a study empl...
Yuka Sasaki
Yuka Sasaki
Prostaglandins (PGs) are oxygenated derivatives of arachidonic acid, synthesized through sequential catalysis involving cyclooxygenase (COX) and PG terminal synthases. Of the two COX enzymes, COX-2 is induced by inflammatory and pro-carcino...