Concerns and Consultation Needs for Hospital and Community Pharmacists at Metastatic or Recurrent Cancer Diagnosis: A Web-Based Survey in Japan [0.03%]
日本医院和社区药剂师在转移性或复发性癌症诊断方面的关注点和咨询需求：一项基于网页的调查研究
Tomofumi Watanabe,Atsunobu Sagara,Tomoya Abe et al.
Tomofumi Watanabe et al.
Patients diagnosed with metastatic or recurrent cancer experience uncertainty and distress; however, their consultation needs remain insufficiently quantified. We conducted a web survey in Japan (January 23-29, 2025) among adults (≥18 year...
[Perspectives on the Future of Antibody Therapeutic Use for the Prevention and Treatment of Infectious Diseases] [0.03%]
[关于抗体治疗在感染性疾病预防和治疗中的未来应用前景的思考]
Minoru Tada,Michihiko Aoyama,Akiko Ishii-Watabe
Minoru Tada
Antibodies are endogenous proteins that are involved in humoral immunity. Although various therapeutic monoclonal antibodies (mAbs) targeting cancer and immune diseases have been widely used, the development of mAbs for the treatment of inf...
[Blood-Retinal Barrier Drug Transport: Aiming to Develop Oral Administration for Retinal Diseases] [0.03%]
[血视网膜屏障药物转运：旨在开发治疗视网膜疾病的口服给药方式]
Ken-Ichi Hosoya
Ken-Ichi Hosoya
The blood-retinal barrier (BRB) consists of the inner and outer blood-retinal barrier (abbreviated as inner BRB and outer BRB). The inner and outer BRB's together regulate the transport of substances between the blood and neural retina via ...
[Development of Drug Discovery Research Based on the Discovery of AlkB Homolog 3 and Establishment of an Academic Drug Discovery Platform] [0.03%]
基于Alkb同源物3的药物发现研究的开发及学术新药发现平台的建立
Kazutake Tsujikawa
Kazutake Tsujikawa
The field of epitranscriptomics, an area of genetics concerning the regulation of gene expression via post-transcriptional RNA modification, is currently attracting substantial research attention. In epitranscriptomics, proteins, collective...
Yoshitaka Saito
Yoshitaka Saito
Managing adverse events is important for optimizing cancer treatment and ensuring high patient satisfaction. Studies have assessed (1) anti-epidermal growth factor receptor (EGFR) monoclonal antibody-induced skin toxicities, (2) development...
[Effect of Application Device Design on Scalp Delivery of Topical Minoxidil Formulations] [0.03%]
[给药装置设计对外用米诺地尔制剂经皮传递的影响]
Ayano Kojima,Hiroaki Todo,Yutaka Inoue et al.
Ayano Kojima et al.
Equivalence of OTC formulations is generally assessed based on pharmaceutical attributes such as active ingredient content, dissolution behavior, and stability. However, for topical liquid formulations that are directly applied to the skin ...
[Survey of Pharmaceutical Interventions in Outpatient Cancer Chemotherapy] [0.03%]
门诊癌症化疗的药学干预措施调查分析
Konomi Shiba,Masahiro Ohgami,Shigeki Tachihara et al.
Konomi Shiba et al.
In recent years, cancer chemotherapy has been administered in an outpatient setting; therefore, patient self-management of adverse events is an important issue. Pharmaceutical interventions were performed by pharmacists at the following 3 t...
Effects of Fluctuating Triglyceride Levels on Initial and Steady-state Serum Amiodarone Concentrations in Japanese Patients: A Retrospective Study [0.03%]
日本患者的血脂波动对初始及稳态下阿米одารون血药浓度的影响：回顾性研究
Ryota Takahashi,Takashi Tsujimoto,Naoko Ozaki et al.
Ryota Takahashi et al.
Amiodarone (AMD) is characterized by complex pharmacokinetics involving high lipophilicity and extensive protein binding. Serum AMD concentrations are influenced by triglyceride (TG) levels. Although the impact of TG on AMD concentrations a...
[Dynamic Oligomerization Processes and Functional Characterization of Bacterial ClpP Protease] [0.03%]
细菌ClpP蛋白酶的动态寡聚化过程及其功能表征
Fumihiro Ishikawa
Fumihiro Ishikawa
ClpP protease is a highly conserved serine protease that plays a crucial role in bacterial protein quality control alongside its partner AAA+ ATPases. ClpP assembles into a barrel-shaped tetradecamer that degrades unfolded or misfolded prot...
[Structural Analysis Using Cryo-electron Microscopy for Protein-based Drug Design] [0.03%]
基于结构的药物设计中的冷冻电镜技术及其应用
Jun-Ichi Kishikawa
Jun-Ichi Kishikawa
Structure-based drug design (SBDD) plays a crucial role in modern drug discovery. SBDD is a methodology that utilizes the three-dimensional (3D) structural information of a target protein to computationally search for compounds that bind to...