Masaaki Kurihara
Masaaki Kurihara
We performed the design, synthesis and evaluation of ligands of nuclear receptors [vitamin D receptor (VDR), retinoid receptor and a VDR mutant], stapled short helical peptides as VDR-coactivator interaction inhibitors, and estrogen recepto...
[Challenging the Elucidation of Anti-inflammatory Mechanisms Using Chemical Probes of Resolvins] [0.03%]
挑战利用化学探针研究消炎机制的研究论文
Hayato Fukuda
Hayato Fukuda
Resolvins are endogenous polyunsaturated fatty acids that show strong anti-inflammatory activity and are therefore expected to be promising new anti-inflammatory drug candidates. However, resolvins have many problems, including instability....
[Development of a Liver Fibrosis Treatment Targeting Inhibition of Hepatic Stellate Cell Activation] [0.03%]
肝星状细胞活化抑制作用的肝纤维化治疗靶点确立研究
Momoka Yamaguchi
Momoka Yamaguchi
Chronic liver disease causes approximately 2 million deaths annually worldwide, accounting for nearly 4% of global mortality. Liver fibrosis is a central pathological feature driving the progression of chronic liver disease (CLD), irrespect...
Incidence and Management of Tirabrutinib-associated Cutaneous Adverse Events: A Case Series [0.03%]
泰拉布替尼相关的皮肤不良事件的发病及处理：病例系列分析
Satoru Matsunuma,Harutaka Seshimo,Shigeki Sunaga et al.
Satoru Matsunuma et al.
Cutaneous adverse events associated with tirabrutinib have been reported in clinical trials; however, their overall incidence and severity vary, and real-world data remain limited. This study aimed to assess the incidence and management of ...
[Evaluation of Pharmacist Interventions to Prevent Acute Kidney Injury Associated with the Combination of Piperacillin/Tazobactam and Vancomycin] [0.03%]
药师干预评估以预防哌拉西林/他唑巴坦与万古霉素联用引起的急性肾损伤事件
Nobuaki Sampa,Kengo Ohashi,Yasutaka Shinoda et al.
Nobuaki Sampa et al.
Piperacillin/tazobactam (PIPC/TAZ) and vancomycin (VCM) are frequently used in combination (PTV) to manage severe healthcare-associated infections, but are also associated with an increased risk of acute kidney injury (AKI). In 2019, Ogaki ...
[Elucidation of a Novel Protective Function of AADAC Against Drug-induced Liver Injury through Ferroptosis Suppression] [0.03%]
AADAC通过抑制铁死亡的新保护功能防治药物性肝损伤
Tatsuki Fukami
Tatsuki Fukami
Drug-induced liver injury (DILI) remains a major cause of drug withdrawal from the market, and safety concerns in clinical settings. Reactive metabolites, primarily produced by cytochrome P450 enzymes, are known to induce oxidative stress a...
Shigeki Aoki,Akira Kazaoka,Kousei Ito
Shigeki Aoki
Idiosyncratic drug-induced liver injury (iDILI) is a rare but serious adverse reaction that occurs only in a small subset of individuals. Traditionally, drug-induced liver injury has been studied primarily through the lens of hepatocellular...
[Inflammasome Activation and Idiosyncratic Drug-induced Liver Injury: Fusion Study of Basic and Real-world Data] [0.03%]
炎症小体激活与特异质性药物性肝损伤：基础与临床证据融合研究
Ryuji Kato
Ryuji Kato
Idiosyncratic drug-induced liver injury (IDILI) is particularly problematic due to its severity and unpredictability. Various pathogenic mechanisms have been proposed for IDILI; however, these mechanisms have yet to be comprehensively eluci...
[Association between the Risk of Drug-induced Liver Injury and the Reactive Metabolites Acyl Glucuronides] [0.03%]
[药物性肝损伤风险与活性代谢产物酰基葡萄糖醛酸酯的关系]
Atsushi Kawase,Hiroaki Shimada,Fuminori Sakurai
Atsushi Kawase
Acyl glucuronides (AG), reactive metabolites formed via the glucuronidation of carboxylic acid-containing drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), are closely associated with drug-induced liver injury (DILI), particular...