[Semi-rational Design of Target-binding Small Proteins for Cancer Treatment] [0.03%]
[癌症治疗的靶向结合小蛋白的半理性设计]
Tetsuya Kadonosono,Shinae Kizaka-Kondoh
Tetsuya Kadonosono
Small proteins that have a high affinity for cancer cell surface markers can be promising cheap alternatives to antibodies (antibody mimetics). Various types of antibody mimetics have thus been extensively developed. We recently found that ...
Keiichiro Okuhira
Keiichiro Okuhira
Atherosclerosis is a vascular disease responsible for acute heart attacks and stroke, which are leading causes of death not only in industrialized countries but also worldwide, and the number of patients afflicted by this disease has been i...
Masaharu Somiya,Shun&#x;ichi Kuroda
Masaharu Somiya
Viruses are natural nanocarriers that deliver various biological cargos, such as DNA, RNA, and proteins. We are developing a new nanocarrier by mimicking the early mechanism of infection by hepatitis B virus (HBV). When the HBV envelope L p...
[Strategy of Drug Development Based on the Bioactive Gas-carrying Capacity of Hemoglobin] [0.03%]
[基于携气能力的血红蛋白药物研发策略]
Kazuaki Taguchi,Kazuaki Matsumoto,Toru Maruyama et al.
Kazuaki Taguchi et al.
Bioactive gas molecules, including oxygen, nitric oxide and carbon monoxide (CO), exhibit a variety of physiological activities, and are associated with the onset and progress of some disorders. These facts have led researchers to the devel...
Yu Ishima,Kazuaki Taguchi
Yu Ishima
Kenichi Harada
Kenichi Harada
(-)-2S,3S,4S,5S-Talaumidin (1) exhibits potent neurotrophic activities such as neurite-outgrowth promotion and neuroprotection in primary cultured rat cortical neurons and in nerve growth factor (NGF)-differentiated PC12 cells. To examine t...
[Unraveling the Pathogenesis of Inflammatory Bowel Disease and Search for New Therapeutic Medicines] [0.03%]
[探究炎症性肠病发病机制及寻觅新药治疗]
Shusaku Hayashi
Shusaku Hayashi
The breakdown of the intestinal mucosal barrier has been shown to play a key role in the pathogenesis of intestinal immune-related disorders such as inflammatory bowel disease (IBD). IBD is a chronic inflammatory disorder with intermittent ...
[Development of Cancer-targeted Theranostics Probes Based on the Physicochemical Properties of Water-soluble Macromolecules] [0.03%]
基于水溶性高分子的理化性质发展的癌症治疗诊断探针研究
Kohei Sano
Kohei Sano
Water-soluble macromolecules, such as polymers and monoclonal antibodies, have some advantages, including high water solubility, high biocompatibility, a wide range of molecular weights, and amenability to easy modification through the term...
[Examination of the Usefulness of Health Consultations in Community Pharmacies for Elderly People] [0.03%]
社区药房健康咨询对老年人的价值调查研究
Yasunori Osanai,Hidehiko Sakurai
Yasunori Osanai
In this study, we conducted a web-based survey of 800 elderly people to clarify sex and regional differences in the usefulness of individual health consultations in community pharmacies for improving the health of elderly people. The result...
[Factors Resulting Correlation and Differences in Renal Function Evaluation Index Using the Serum Cystatin C and Creatinine as Measured by an Enzymatic Method] [0.03%]
[血清胱抑素C和酶法血肌酐检测估算肾小球滤过率相关及差异的影响因素]
Makoto Takahashi,Sintarou Takayama,Hideyuki Suga et al.
Makoto Takahashi et al.
We previously reported the association of the estimated glomerular filtration rate (eGFRcreat) calculated from the serum creatinine level (S-Cr) measured using the Jaffe method with the GFR (eGFRcys) estimated from the serum cystatin C leve...