[Clinical Pharmacological Research Aiming to Optimize Therapeutic Strategies in Specific Populations] [0.03%]
[旨在优化特定人群治疗方案的临床药理学研究]
Ryota Tanaka
Ryota Tanaka
In the field of drug development, pharmacokinetic studies primarily focus on adult and pediatric populations, resulting in limited pharmacokinetic data for specific populations such as neonates, pregnant women, and critically ill patients. ...
Kyohei Kanomata
Kyohei Kanomata
Enantiomers of a chiral compound often exhibit distinct physiological activities, making enantioselective synthesis of chiral molecules a critical challenge in drug discovery. This study explored a novel strategy for converting racemic comp...
[Diversification of Unsaturated Hydrocarbons via An Azo-Ene Reaction] [0.03%]
通过偶氮烯烃反应进行不饱和烃的官能团化及多样性转化研究
Yusuke Kuroda
Yusuke Kuroda
Unsaturated hydrocarbons represent one of the most abundant and synthetically versatile classes of organic molecules. Consequently, the development of new strategies to enable their facile transformation into value-added molecules is a long...
[Development of Mid-size Bivalent Inhibitors Targeting a Cancer-related Kinase] [0.03%]
[针对与癌症相关激酶的中等大小二价抑制剂的开发]
Kohei Tsuji
Kohei Tsuji
The Ser/Thr-specific kinase, polo-like kinase 1 (Plk1), is a crucial eukaryotic cell cycle regulatory protein. Overexpression of this kinase is observed in many cancer cells and where it can be related to their aggressiveness. Dysfunction o...
[Analysis of Asparagine Deamidation and Its Impact on γS-Crystallin Aggregation] [0.03%]
天冬酰胺脱氨及其对γs-晶体蛋白聚集的影响分析
Koichi Kato
Koichi Kato
Nonenzymatic posttranslational modifications of proteins occur under physiological conditions, leading to structural alterations and functional impairments that contribute to age-related diseases and reduced efficacy of antibody drugs. Amon...
[Prediction of Severe Skin Disorders Induced by Anti-epidermal Growth Factor Receptor Antibody Drugs] [0.03%]
[抗表皮生长因子受体抗体药物诱发严重皮肤障碍的预测研究]
Hiroaki Takahashi
Hiroaki Takahashi
In cancer drug therapy involving anti-epidermal growth factor receptor (EGFR) antibody drugs, skin disorders such as acneiform rash are frequently observed and often progress to severe forms, resulting in treatment discontinuation. The seve...
Yayoi Aoki,Taiki Shimoyama,Seiwa Michihara et al.
Yayoi Aoki et al.
Dysmenorrhea refers to pathological symptoms that occur in association with menstruation during the menstrual period. Treatment options for dysmenorrhea include nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose estrogen-progestin c...
[A Preliminary Study on the Influence of Male Community Pharmacists' Appearance on Patient Trust: A Conjoint Analysis Approach] [0.03%]
[关于药师外观对患者信任影响的共变研究初探]
Keiko Kishimoto,Riku Takahashi,Keiko Akagawa et al.
Keiko Kishimoto et al.
The primary aim of this study is to examine whether the appearance of pharmacists in Japan is an issue worthy of discussion. A web-based survey was conducted in June 2023 among 500 men and women aged 25-74 (male/female ratio=1 : 1, equally ...
[Low Abuse Potential of Plant-Derived Highly Purified Cannabidiol: A Narrative Review] [0.03%]
植物来源的高纯度大麻二酚滥用可能性低：一篇叙述性评论
Hitoshi Yamamoto,Satish Dayal,Charlotte Nortvedt et al.
Hitoshi Yamamoto et al.
Cannabidiol (CBD) is an abundant phytocannabinoid extracted from Cannabis sativa L., along with delta-9-tetrahydrocannabinol. Plant-derived, highly purified CBD oral solution (100 mg/mL) is approved as Epidiolex® in the United States and a...
[Antithrombotic Action of Resveratrol: Particularly Regarding Inhibition of Platelet Aggregation] [0.03%]
白藜之抗血栓作用：特别是关于抑制血小板凝集方面的作用
Kazumi Ekawa,Mikio Marumo,Ichiro Wakabayashi
Kazumi Ekawa
Resveratrol is a representative polyphenol compound contained in red wine that shows a preventive effect on ischemic heart disease and was originally reported to explain the cause of the French paradox. Alcoholic beverages, including red wi...