[Trends in Spontaneous Adverse Event Reports Following the Expansion of Pembrolizumab Indications in Japan] [0.03%]
帕博利珠单抗适应症扩大后不良事件自发报告趋势分析
Kana Yamamoto,Ryoko Sakai,Manabu Akazawa
Kana Yamamoto
Pembrolizumab is an immune checkpoint inhibitor that has been widely used in cancer treatment, and its approved indications have expanded rapidly in recent years. However, the effects of this increase on immune-related adverse events (irAEs...
Usefulness of the Risk Management Plan (RMP) Pocket Edition in Pharmacists' Practice in Community Pharmacies: A Questionnaire-Based Study [0.03%]
基于问卷的调查：风险管理计划（RMP）便携版在社区药房药师实践中的作用性研究
Takashi Omoto,Manato Inagaki,Junichi Asaka et al.
Takashi Omoto et al.
Risk management plan (RMP) utilization in clinical settings has been reported to be insufficient, particularly in community pharmacies. To facilitate the utilization of RMPs in pharmacists' practice, we created an "RMP Pocket Edition" by su...
[Identification of Factors Associated with Supratherapeutic Voriconazole Concentrations Using Decision Tree Analysis] [0.03%]
[使用决策树分析法鉴定超治疗浓度伏立康唑相关因素]
Airi Suzuki,Toshiaki Komatsu,Yumi Uemura et al.
Airi Suzuki et al.
Voriconazole (VRCZ) is a first-line agent for treating invasive fungal infections, but its pharmacokinetics vary widely, necessitating therapeutic drug monitoring (TDM) to maintain trough concentrations within the therapeutic range (1.0-4.0...
Long-Term Patient-Reported Symptom Control with an Ibuprofen Gargle in Oral Lichen Planus: An Exploratory Analysis of a Randomized Crossover Trial and Extension [0.03%]
一项随机交叉试验和扩展研究中口疮样狼疮患者使用布洛芬含漱剂的长期疗效：探索性分析
Takeshi Ioroi,Yasumasa Kakei,Yumi Kitahiro et al.
Takeshi Ioroi et al.
Oral lichen planus (OLP) causes chronic pain and functional limitations. In a randomized, placebo-controlled crossover trial of ibuprofen gargle, short-term analgesia on the visual analog scale (VAS) was not statistically significant, altho...
Randomized Controlled Trial
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2026;146(5):507-515. DOI:10.1248/yakushi.25-00169 2026
[Evaluating the Validity of the Action Limit and Predicted Environmental Concentration (PEC) in Environmental Risk Assessment Guidance for Novel Human Pharmaceuticals in Japan] [0.03%]
[评估日本新型人类药物环境风险指南中作用限值和预测环境浓度(Pec)的有效性]
Shigechika Yamamoto,Taeko Maruyama-Komoda,Kenichi Masumura et al.
Shigechika Yamamoto et al.
As human pharmaceuticals are physiologically active substances, it is essential to assess their potential risk to ecosystems after being released into the environment. In Japan, the "Guidance on the Environmental Risk Assessment in New Phar...
[Enantioselective Aldol Related-Reactions Catalyzed by Organic Oxides] [0.03%]
[有机氧化物催化的不对称 aldol 反应及相关反应]
Makoto Nakajima
Makoto Nakajima
This paper reviews enantioselective aldol-related reactions catalyzed by organic oxides (e.g., phenoxides, N-oxides, phosphine oxides, annulenones) developed in the author's group. Chiral phenoxides catalyze the aldol-Tishchenko reaction, t...
[Function, Regeneration, and Proliferation of Pancreatic β-Cells Centered on NAD] [0.03%]
以NAD为中心的胰岛β细胞的功能、再生和增殖
Koji Nata
Koji Nata
The author retired from Iwate Medical University in March 2025 upon reaching mandatory retirement age. On this milestone occasion, I was given the opportunity to write a review article for Yakugaku Zasshi. This review primarily outlines res...
[Current Situation and Future Directions of Dispensing Support Tasks Conducted by Nonpharmacist Dispensing Assistants/Support Staff] [0.03%]
[当前形势及药学专业外调配助理未来发展方向]
Kayoko Takeda
Kayoko Takeda
This study aimed to clarify the current status of dispensing assistance and support tasks performed by nonpharmacists and to provide recommendations on quality assurance for these activities. The survey targeted Japanese pharmacists and non...
[Prospects for Improving the Efficiency and Precision of Pharmaceutical Preparations: The Perspective of Pharmaceutical Equipment and Machinery Manufacturers] [0.03%]
[提高药品制剂效率和精准性的前景——制药设备与机械制造商的视角]
Masashi Yuyama
Masashi Yuyama
The pharmacist's responsibilities are shifting from product-based to patient-centered services. This review examines the current status and effectiveness of dispensing equipment and highlights the challenges to achieving efficient and high-...
[Prospects for Improving the Efficiency and Accuracy of Pharmaceutical Preparations: The Perspective of Pharmaceutical Companies] [0.03%]
[提高药品制剂效率和准确性的前景展望——制药公司的视角]
Masahiko Kikuchi
Masahiko Kikuchi
There are approximately 60000 pharmacies in Japan. Effective utilization of this resource is a critical national public health issue. With the advent of work style reforms for physicians, pharmacists have a substantial scope to undertake in...