Evaluation of Transport Activity Using Mouse Jejunal Epithelial Cell Monolayer Culture System [0.03%]
采用小鼠空肠上皮细胞单层培养系统评价药物转运效应
Yoshiki Sasagawa,Riho Kamishima,Hitoshi Kashiwagi et al.
Yoshiki Sasagawa et al.
Caco-2 cells, derived from colorectal cancer cells, are generally used to evaluate drug absorption in the gastrointestinal tract. However, differences between Caco-2 and normal intestinal cells have been observed. Cells cultured directly fr...
Enhancement of Immune Modulation by Toll-Like Receptor 9 Adjuvant Combination Subcutaneous Immunotherapy for Japanese Cedar Pollinosis [0.03%]
TLR9佐剂联合皮下免疫疗法对日本扁柏花粉症免疫调节功能的增强作用研究
Daichi Utsumi,Keisuke Suzuki,Hiroki Matsuhara et al.
Daichi Utsumi et al.
Allergy immunotherapy (AIT) plays a pivotal role in the treatment of type I allergic conditions such as allergic rhinitis and rhinoconjunctivitis. However, AIT faces persistent issues, notably the risk of anaphylaxis and the need for long-t...
Aiko Shono,Shu-Ling Hoshi,Masahide Kondo
Aiko Shono
As of 2024, herpes zoster (HZ) vaccination for older adults was not included in Japan's routine vaccination program. Two types of HZ vaccines are currently available at the individual's expense. In this study, we surveyed program details fo...
Bingqing Cui,Jianming Wei,Huiting Peng et al.
Bingqing Cui et al.
Sphingosine kinase 1/2 (SphK1/2) promote the initiation and advancement of breast cancers. We performed screening on a compound library of SphK inhibitors using computer molecular docking and selected the most representative compound, ZFP-B...
Reactivating Circadian Rhythms as a Therapeutic Strategy: Insights from Basic Research [0.03%]
从基础研究角度看作为治疗策略的昼夜节律重启疗法的见解
Masao Doi
Masao Doi
One of the most significant conceptual changes brought about by the discovery of clock genes and development of circadian-clock mutant mice is the recognition that impaired circadian rhythmicity extends its impact far beyond sleep, driving ...
Semantics of Brain-Machine Hybrids [0.03%]
脑机混合体的语言 semantics of brain-machine hybrids 中文翻译为 脑机混合体的语言
Yuji Ikegaya
Yuji Ikegaya
Brain-machine interfaces, also known as brain-computer interfaces, represent a rapidly advancing field at the intersection of neuroscience and technology, enabling direct communication pathways between the brain and external devices. This r...
Risk Factors for Delirium in Patients with Acute Heart Failure: A Systematic Review and Meta-Analysis [0.03%]
急性心力衰竭患者谵妄的危险因素：系统回顾和荟萃分析
Tetsushi Kawazoe,Tomoaki Ishida,Kohei Jobu et al.
Tetsushi Kawazoe et al.
Delirium is an acute, potentially life-threatening condition characterized by altered attention, disorganized thinking, and changes in consciousness. It frequently occurs in hospitalized patients with acute heart failure (AHF). In this meta...
Bleeding Risk in the Early Postoperative Period after Atrial Fibrillation Ablation with Anticoagulant Therapy Using Dabigatran Etexilate [0.03%]
达比加群酯抗凝治疗的心房颤动消融术后早期出血风险分析
Yasuyuki Takashima,Kosuke Doki,Yasutoshi Shinoda et al.
Yasuyuki Takashima et al.
The bleeding risk associated with dabigatran etexilate (DABE) dosing remains unclear in patients undergoing catheter ablation for atrial fibrillation (AF) because these patients were excluded from the pivotal clinical trial of DABE. This st...
Suppressive Effects of JTE-151, a Novel Orally Available RORγ Antagonist, in Experimental Models of Rheumatoid Arthritis [0.03%]
一种新型口服有效的RORγ拮抗剂JTE-151的抑制作用及其在实验性关节炎模型中的效果研究
Kojo Arita,Sho Otake,Kazuma Kobayashi et al.
Kojo Arita et al.
Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic joint inflammation and cartilage damage. The main treatment goal of RA is clinical remission using various kinds of disease-modifying antirheumatic drugs (DMA...
Action-at-a-Distance Mutations Induced by the True Abasic Site, Uracil, and Nicks: Unexpectedly Lower Mutagenicity of the True Abasic Site [0.03%]
真正的.AP位点、尿嘧啶和切口诱导的远距离突变：.AP位点出人意料的低致突变性
Tetsuya Suzuki,Kiyoharu Yasui,Hiroki Takata et al.
Tetsuya Suzuki et al.
A major oxidized base, 8-oxo-7,8-dihydroguanine (GO, 8-hydroxyguanine), is involved in cancer initiation. GO induces untargeted base substitution (action-at-a-distance) mutations as well as targeted G→T transversions in human cells. Uracil...