He-Wei-Decoction Ameliorates Chronic Atrophic Gastritis via Modulation of the TLR4/NF-κB Signaling Pathway [0.03%]
归参解毒汤通过调节TLR4/NF-κB信号通路改善慢性萎缩性胃炎
Dongguo Lin,Guangwei Wang,Yan Ge et al.
Dongguo Lin et al.
He-Wei-Decoction (HWD), a traditional Chinese medicine formula, emphasizes "strengthening the spleen and supplementing qi (Jianpi Yiqi)," and "resolving stasis and detoxifying (Huayu Jiedu)." This formula has been utilized in the treatment ...
ROBO3 Drives Endometriosis Progression via Dual Wnt/β-Catenin Activation and M2 Macrophage Polarization [0.03%]
ROBO3通过双重Wnt/β-catenin激活和M2型巨噬细胞极化促进子宫内膜异位症进展
Xinyue Zhou,Wei Zhou,Changhong Qu et al.
Xinyue Zhou et al.
Endometriosis, a prevalent gynecological disorder marked by ectopic growth of endometrial-like tissue, demonstrates malignant tumor-like properties including aggressive adhesion and invasiveness. Emerging evidence implicates roundabout guid...
Association of Plasma Creatinine with Systemic Exposure to S-1 and Oxaliplatin in Two Types of Chronic Kidney Disease Animal Models [0.03%]
慢性肾脏病动物模型中血清肌酐与口服S-1和静脉给药奥沙利铂系统暴露量的关系研究
Takumi Tanaka,Aika Tanaka,Shinji Kobuchi et al.
Takumi Tanaka et al.
Chronic kidney disease (CKD) is a serious chemotherapy-associated clinical condition. CKD complicates the pharmacokinetics of anticancer drugs, requiring personalized dosing strategies to minimize toxicity. S-1 and oxaliplatin (the SOX regi...
Mitochondrial Coenzyme Q10 Delivery Improves Energy Production in Rat Cardiac Myoblasts and Duchenne Muscular Dystrophy Model Rat Cardiomyocytes [0.03%]
辅酶Q10胞质递送改善大鼠心脏成肌细胞和杜氏型肌肉营养不良模型大鼠心肌细胞的能量生成
Itsumi Sato,Daisuke Sasaki,Jiro Abe et al.
Itsumi Sato et al.
Enhancing cardiomyocyte mitochondrial function has been reported as a potential therapeutic approach for various diseases. However, this is technically difficult, and its practical use has not been described. Although treatments such as exo...
Induction of Melanin Synthesis by Pueraria lobata Leaves in B16 Murine Melanoma Cells and Three-Dimensional Human Skin Equivalent [0.03%]
刺五加叶诱导小鼠黑色素瘤细胞及人体三维重建皮肤模型黑色素合成的作用研究
Takuhiro Uto,Tomoe Ohta,Mana Kairada et al.
Takuhiro Uto et al.
Puerariae Radix, the root of Pueraria lobata (Willd.) Ohwi is primarily used as a traditional herbal medicine in East Asia. Although phytochemical and biological investigations of the roots have been well-reported, those of the leaves are l...
Quercetin, a Natural Dietary Flavonoid, Emerges a Novel USP7 Inhibitor with Anti-colorectal Cancer Effects [0.03%]
天然膳食黄酮类化合物橡椀素是新型USP7抑制剂并可抑制结直肠癌效应
Xue Li,Qiyan Li,Ying Huang et al.
Xue Li et al.
The human deubiquitinating enzyme ubiquitin-specific peptidase 7 (USP7) has emerged as a promising anti-tumor target, particularly in colorectal cancer, due to its regulation of the MDM2/p53 axis. Through a combination of ubiquitin C-termin...
Placental Extract Inhibits Melanogenesis by Inducing the Proteasome-Dependent Degradation of Tyrosinase and TRP-1 [0.03%]
胎盘提取物通过泛素-蛋白酶体系统降解酪氨酸酶和TRP-1抑制黑色素生成
Mie Moriya
Mie Moriya
Placental extract (PE) is employed as a skin-whitening agent in Japan, where this material is used in cosmetics and dietary supplements. However, the mechanism of PE's anti-melanogenic activity remains poorly understood. The goal of the pre...
Disruption of Tight Junctions in Intestinal Epithelial Cells by Toxic Advanced Glycation End-Products [0.03%]
肠毒素晚期糖基化终产物通过破坏紧密连接来损伤肠上皮通透性
Ryoma Takeda,Eisei Hori,Misaki Natori et al.
Ryoma Takeda et al.
Intestinal epithelial cells (IECs) play a crucial role in forming a protective barrier and regulating the absorption of substances passing through the small intestine. Disrupting the epithelial barrier function can result in intestinal dise...
Effect of 2-Hydroxypropyl-γ-cyclodextrin on Renal Inflammation in Alport Mouse Model [0.03%]
2-羟丙基环糊精对Alport综合征小鼠模型肾脏炎症的影响研究
Jun Horizono,Keito Mizumoto,Mary Ann Suico et al.
Jun Horizono et al.
Cyclodextrins (CDs) are cyclic oligosaccharides that encapsulate hydrophobic molecules such as cholesterol. Hydroxypropyl-β-cyclodextrin (HP-β-CD), a cyclic heptasaccharide, has gained attention as a protective agent for chronic kidney di...
Docosahexaenoic Acid Targets TRPC3/6 Channels to Suppress Noradrenaline-Induced Contraction in Rat Vas Deferens Smooth Muscle [0.03%]
岩藻二十二碳六烯酸通过靶向TRPC3/6通道抑制去甲肾上腺素诱导的输精管平滑肌收缩作用
Keisuke Obara,Miwa Enomoto,Mio Furuta et al.
Keisuke Obara et al.
We investigated the effects of docosahexaenoic acid (DHA) on noradrenaline (NA)-induced contractile responses in rat vas deferens smooth muscle (VDSM). DHA (3 × 10-6-3 × 10-5 M) significantly inhibited phasic contractions induced by NA (3...