Mitochondrial Membrane-Associated L-2-Hydroxyglutarate Dehydrogenase Catalyzes Electron Transport to Ubiquinone In Vitro [0.03%]
线粒体膜结合的L-2-羟基戊二酸脱氢酶催化电子传递给辅酶Q
Takeshi Ito,Taiyo Yokoi
Takeshi Ito
Mitochondrial L-2-hydroxyglutarate dehydrogenase (L2HGDH) is a FAD-containing membrane protein that oxidizes L-2-hydroxyglutarate (L-2-HG) to 2-oxoglutarate (2-OG). L2HGDH dysfunction is associated with human diseases, such as neurometaboli...
Aromatic-Turmerone Analogs Activate Chaperone-Mediated Autophagy and Ameliorate Dendritic Shrinkage in Purkinje Cell Models of Spinocerebellar Ataxia [0.03%]
芳香檀香酮类似物激活分子伴侣介导的自噬并改善齿状细胞模型中脊髓小脑共济失调的树突收缩
Kensuke Motomura,Erika Ueda-Ishizaka,Alex Boateng et al.
Kensuke Motomura et al.
We recently demonstrated that aromatic (ar)-turmerone analogs ((E)-5-methyl-1-(p-tolyl)hexa-1,4-dien-3-one [A2] and (E)-1-(4-methoxyphenyl)-5-methylhexa-1,4-dien-3-one [A4]) activate chaperone-mediated autophagy (CMA), a pathway in the auto...
Modeling Hypertrophic Cardiomyopathy-Related MYH7 Variants: Insights into Structural Changes and Cardiovascular Drug-Binding Affinities [0.03%]
肥厚型心肌病相关MYH7变异的建模：结构变化和心血管药物结合亲和力的见解
Nadia Widjaja,Doni Dermawan,Santi Tan et al.
Nadia Widjaja et al.
Mutations in the MYH7 gene, which encodes β-myosin heavy chain (β-MHC), are a significant cause of hypertrophic cardiomyopathy (HCM). These variants may lead to variable clinical outcomes, thereby influencing responsiveness to targeted th...
Rutin Protects Ischemic Stroke-Induced Astrocytic Injury by Activating PRDX1 [0.03%]
rutin通过激活prdx1保护缺血性脑卒中诱导的星形胶质细胞损伤
Ali Said,Shuai Liu,Ruiqi Cao et al.
Ali Said et al.
Ischemic stroke is a highly destructive disease with extremely high mortality and disability rates. So far, there have been few available neuroprotective drugs. Rutin, a natural plant alkaloid derived from the flavonoid class of natural com...
Magnesium Deficiency Disrupts Blood Glucose Homeostasis in a Time-of-Day-Dependent Manner [0.03%]
镁缺乏以时间依赖的方式破坏血糖稳态
Sora Inoue,Minato Uemura,Yuji Ikegaya et al.
Sora Inoue et al.
Magnesium deficiency (MgD) disrupts numerous physiological processes, yet its specific impact on in vivo glucose homeostasis remains unclear. This study investigated the longitudinal effects of MgD on blood glucose dynamics in freely moving...
Protective Effects of the Phytocannabinoid Cannabidiol on Disuse-Induced Muscle Atrophy through Modulation of Proteolysis and Mitochondrial Regulation [0.03%]
大麻二酚通过调节蛋白降解和线粒体功能对失用性肌肉萎缩的保护作用
Hiromasa Kato,Iori Uratsuji,Yui Nakadai et al.
Hiromasa Kato et al.
Muscle atrophy induced by prolonged inactivity (disuse), including denervation-induced atrophy, is accompanied by oxidative stress, inflammation, and dysregulated protein turnover, yet no effective pharmacological therapy is currently avail...
Acetic Acid-Induced Writhing Is Temporally Dissociated from Gastrointestinal Motility in Freely Moving Rats [0.03%]
乙酸诱导的扭体与自由活动大鼠胃肠动力在时间上相互独立
Honoka Kuroyanagi,Hayato Kusakabe,Yuji Ikegaya et al.
Honoka Kuroyanagi et al.
The acetic acid-induced writhing test is a standard model for visceral pain and analgesic screening. While writhing behavior may have been implicitly assumed to be associated with gastrointestinal motor activity, whether gastrointestinal mo...
Economic Burden of Cachexia in Japanese Lung Cancer Patients: A Retrospective Claims Database Analysis [0.03%]
日本肺癌恶病质患者的经济负担：回顾性保险数据库分析
Munenobu Kashiwa
Munenobu Kashiwa
Cancer cachexia is associated with poor clinical outcomes in lung cancer patients; however, its economic impact in Japan remains largely uncharacterized. This study quantified the incremental healthcare costs associated with cachexia in Jap...
An Oligodeoxynucleotide from Lactic Acid Bacteria Promotes the Differentiation of Endothelial Cells from Induced Pluripotent Stem Cells [0.03%]
一种来源于乳酸菌的寡脱氧核糖核酸能够促进诱导多能干细胞向内皮细胞分化
Tomoko Yamaguchi-Shibano,Misae Nishijima,Tomohide Takaya et al.
Tomoko Yamaguchi-Shibano et al.
Bacterial genome-derived oligodeoxynucleotides (ODNs) are recognized as pathogen-associated molecular patterns by Toll-like receptors. They induce inflammatory responses by activating the innate immune response. Recently, ODNs reported to r...
Tramadol Eye Drop Reduces Ocular Nocifensive Behavior Not Primarily Mediated by μ-Opioid Receptor Activation in a Rat Dry Eye Model [0.03%]
tramadol滴眼液可通过非μ-阿片受体介导的机制有效缓解干眼大鼠模型中的眨眼反射增多症状
Shogo Nagaoka,Yoshihiro Takai,Takeshi Kiyoi et al.
Shogo Nagaoka et al.
This study aimed to explore the possibility of using a novel eye drop for ocular pain in dry eyes by examining the effect of tramadol eye drops on nocifensive behavior in normal and dry eye rats. Dry eye model rats were generated by the uni...