Altered Levels of Phospholipids and Lysophospholipids in Adipose Tissues of Bilaterally Adrenalectomized Rats Receiving Drinking Water [0.03%]
双侧肾上腺切除大鼠脂肪组织中磷脂和溶血磷脂水平的改变收到饮用水的影响
Toshihiko Tsutsumi,Kohei Kawabata,Hiroyuki Nishi et al.
Toshihiko Tsutsumi et al.
Rat adipose tissues were shown to exhibit a high level of autotaxin having lysophospholipase D activity. Previously, we reported that an elevated level of lysophosphatidic acid (LPA) in rat plasma was due to a decreased lysophosphatidylchol...
Evolution of Pharmacy Education and Pharmacist Competency Development in Japan in Response to Changing Healthcare Demands [0.03%]
日本药学教育和药师胜任力发展应对医疗需求变化的演进
Kayoko Takeda Mamiya
Kayoko Takeda Mamiya
This article reviews the historical development and current challenges of pharmacy education in Japan, focusing on structural reform and the shift toward competency-based education. The 1992 revision of the Medical Care Act and the 1993 sor...
Pharmacy Education in Korea: Transition to Clinically Oriented Education and the Establishment of the National Specialist Pharmacist System as a Foundation for Advanced Pharmacy Practice [0.03%]
韩国药学教育：以临床为导向的教育转型及国家级药师专科体系的确立——迈向高级药学实践的基础
Sumiko Hirata
Sumiko Hirata
Pharmacy education in Korea has undergone a substantial transformation over the past two decades in response to healthcare system reforms and the increasing complexity of pharmacotherapy. The nationwide implementation of the separation of p...
Sherly Meilianti,Lailaturrahmi,Dimas Aditya Suhendar et al.
Sherly Meilianti et al.
Pharmacy education in Indonesia is expected to prepare pharmacists for a wide range of roles in a health system where medicines are central to prevention and treatment. Yet workforce studies describing capability gaps, uneven distribution, ...
Kayoko Takeda Mamiya
Kayoko Takeda Mamiya
Effect of Community Pharmacist-Led Dietary Salt Restriction Guidance on Salt Taste Sensitivity in Outpatients with Chronic Kidney Disease: A Pilot Study [0.03%]
社区药剂师主导的限盐指导对慢性肾脏病门诊患者味觉敏感性影响的初步研究
Yuki Asai,Tomohiro Murata,Asami Muramatsu et al.
Yuki Asai et al.
An increased salt taste sensitivity threshold may lead to high salt intake in patients with chronic kidney disease (CKD). The present study aimed to evaluate whether community pharmacist-led dietary salt restriction guidance improved salt t...
Multicenter Study
Biological & pharmaceutical bulletin. 2026;49(7):1169-1173. DOI:10.1248/bpb.b26-00219 2026
A Phenylbutyrate-Derived Nitric Oxide Donor Induces Pancreatic Cancer Cell Death Accompanied by Impairment of Autophagy-Related Pathways and HIF-1α Reduction [0.03%]
基于苯丁酸的供氮化合物通过抑制自噬相关途径和减少HIF-1α诱导胰腺癌细胞凋亡
Kaho Takasaki,Takuro Beppu,Shuhei Imoto et al.
Kaho Takasaki et al.
4-[4-(Bis(2-(nitrooxy)ethyl)amino)phenyl]butanoic acid (NPB), a phenylbutyrate-derived nitric oxide (NO) donor, has been developed as a potential anticancer agent for pancreatic cancer. In the present study, we investigated the cytotoxic ef...
Preventive Effects of Non-sedating and Sedating Histamine H1 Receptor Antagonists Premedication for Subcutaneous Daratumumab-Associated Infusion-Related Reactions: A Prospective Observational Study [0.03%]
非镇静和镇静组胺H1受体拮抗剂预防性用药对皮下注射达拉莫单抗输液反应的预防作用：一项前瞻性观察研究
Mayu Yakumaru-Suzukawa,Tohru Aomori,Norifumi Suzuki et al.
Mayu Yakumaru-Suzukawa et al.
The optimal choice between sedating histamine H1 antagonists (sAHs) and non-sedating histamine H1 antagonists (nsAHs) for preventing infusion-related reactions (IRRs) during daratumumab subcutaneous (DARA-SC) therapy remains unclear. Here, ...
Observational Study
Biological & pharmaceutical bulletin. 2026;49(7):1153-1160. DOI:10.1248/bpb.b26-00011 2026
Increased Interleukin-17C Production by the Toll-Like Receptor 3 Ligand Poly(I:C) in Primary Cystic Fibrosis Airway Epithelial Cells [0.03%]
toll-like受体3配体poly(i:c)增加囊性纤维化原发呼吸道上皮细胞中il-17c的产生
Keiko Ueno-Shuto,Megumi Hayashi,Yukihiro Tasaki et al.
Keiko Ueno-Shuto et al.
Cystic fibrosis (CF) airway disease is characterized by exaggerated inflammatory responses and progressive respiratory failure. Although interleukin-8 (IL-8) is a central mediator of neutrophilic inflammation in the CF airway, the upstream ...
Successive and Isoform-Specific Remodeling of Hepatic Drug-Metabolizing Enzymes during Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis Progression [0.03%]
代谢功能异常相关脂肪肝病/代谢功能异常相关 steatohepatitis 进展过程中肝脏药物代谢酶的连续和异构体特异性重塑
Yusuke Ando,Takumi Arai,Yuki Tsukui et al.
Yusuke Ando et al.
Metabolic dysfunction-associated steatohepatitis (MASH) is frequently accompanied by metabolic comorbidities that require long-term pharmacotherapy. Because the liver plays a central role in drug metabolism, disease-associated alterations i...