Virtual Hepatic and Plasma Exposures of Voriconazole Administered to Cytochrome P450 2C19 Poor Metabolizers Predicted by Simplified and Full Pharmacokinetic Modeling Systems: Possible Causal Factor for Hepatic Disorders Seen in a Japanese Database [0.03%]
通过简化的和全面的药代动力学模型系统预测伏立康唑在细胞色素P450 2C19弱代谢者中的肝内及血浆暴露情况：可能的日籍数据库中所见肝脏疾病的病因因素
Koichiro Adachi,Katsuhiro Ohyama,Yukia Shimura et al.
Koichiro Adachi et al.
The broad-spectrum antifungal agent voriconazole elicits different responses. Polymorphisms in cytochrome P450 (P450) 2C19 may partially explain this variability. This study generated virtual plasma/hepatic exposures to voriconazole in Japa...
Role of Companion Diagnostics in Advancing Patient-Centered Anticancer Drug Treatment [0.03%]
伴随诊断在以患者为中心的抗癌药物治疗中的作用
Nanaki Shingyo,Manaka Taguchi,Mizuki Matsubara et al.
Nanaki Shingyo et al.
Cancer is an age-related disease that affects one in two Japanese individuals, placing a significant burden on both patients and caregivers due to its clinical characteristics, high treatment costs, and associated adverse events (AEs). Cons...
Guanidinylated Chitosan as a Multifunctional Enhancer for Improved Flurbiprofen Delivery [0.03%]
瓜基化壳聚糖作为改善氟比洛芬传递的多功能增效剂
Nowshin Farzana Khan,Hideaki Nakamura,Hironori Izawa et al.
Nowshin Farzana Khan et al.
In this study, we investigated guanidinylated chitosan (GCS), a chemically modified derivative of unmodified low-molecular-weight chitosan (CS), as a multifunctional excipient to enhance the solubility and absorption of poorly water-soluble...
Differences in Approved Doses and Drug Lag in Drugs Approved between 2012 and 2021: A Comparison between Japan and the U.S [0.03%]
2012至2021年日本和美国批准新药的剂量差异及药品滞后分析
Kosuke Koyama,Yuan Abe,Sho Kodama et al.
Kosuke Koyama et al.
In recent years, multinational clinical trials (MCTs) have become a cornerstone of drug development. MCTs involve the participation of multiple regions in a single trial, with regulatory submissions based on the same trial results across al...
Comparative Study
Biological & pharmaceutical bulletin. 2025;48(8):1239-1245. DOI:10.1248/bpb.b25-00030 2025
In Silico Exploration of Therapeutics for GLP-1 Receptor Agonist-Induced Nausea and Their in Vivo Validation in Mice [0.03%]
GLP-1受体激动剂诱导的恶心的药物再定位及在小鼠体内的验证
Norihiro Shibui,Takahide Suzuki,Hiroki Yamamoto et al.
Norihiro Shibui et al.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are clinically used to control hyperglycemia and body weight in patients with type 2 diabetes mellitus and obesity. Despite their efficacy, GLP-1 RAs frequently induce nausea and vomitin...
Tanshinone VI Induces Cardiac Differentiation of Cardiosphere-Derived Cells Prepared from Rat Hearts [0.03%]
丹参酮VI诱导大鼠心脏来源的cardiospherederived细胞分化为心肌细胞
Yuji Kawahara,Tetsuro Marunouchi,Kouichi Tanonaka
Yuji Kawahara
Cell transplantation therapy is a promising new treatment for myocardial infarction and heart failure. Developing methods to promote the engraftment of cardiac stem cells into cardiac tissue and their differentiation into cardiac cells is a...
Sex Differences in Genital Area Hyperpigmentation Induced by 5-Fluorouracil Administration in Mice [0.03%]
5-氟尿嘧啶致小鼠外生殖器区域色素沉着的性别差异研究
Masashi Imai,Keiichi Hiramoto,Kazuya Ooi
Masashi Imai
Pigmentation is one of the most prominent side effects caused by anticancer drugs, especially in female patients, as these changes in appearance can decrease QOL. A typical drug causing such pigmentation is 5-fluorouracil (5-FU); we have pr...
Comparative Proteomic Analysis of Endocytic Cell-Surface Proteins in Vascular and Lymphatic Endothelial Cells [0.03%]
血管内皮细胞和淋巴管内皮细胞的内吞作用细胞表面蛋白质组比较分析
Shingo Ito,Mariko Ohishi,Maki Yamahiro et al.
Shingo Ito et al.
Vascular endothelial cells (VECs) and lymphatic endothelial cells (LECs) regulate the homeostasis of fluids, nutrients, and immune cells in the blood and lymphatic systems, respectively. These specialized functions depend on distinct cell-s...
Comparative Study
Biological & pharmaceutical bulletin. 2025;48(8):1224-1232. DOI:10.1248/bpb.b25-00128 2025
Effects of Low-Dose Atorvastatin on Hypoxic Response in Statin-Sensitive and Statin-Resistant Cancer Cells [0.03%]
小剂量阿托伐他汀对缺氧诱导的不同类型癌细胞的影响研究
Akihiro Sugiura,Tomoko Warita,Jiro Tashiro et al.
Akihiro Sugiura et al.
Statins were initially developed as lipid-lowering agents to reduce the risk of cardiovascular and cerebrovascular diseases. Recently, their anti-tumor effects have gained attention in the context of drug repositioning. However, most in vit...
Inhibitory Effects of Ferulic Acid on Acetylcholine- and Platelet-Activating Factor-Induced Contractions in Guinea Pig Urinary Bladder Smooth Muscle [0.03%]
大肠杆菌中N-乙酰转移酶的分布及其与氨基糖苷耐药性的关系
Keisuke Obara,Futaba Makino,Momoko Tanaka et al.
Keisuke Obara et al.
Ferulic acid (FA), a hydroxycinnamic acid derivative abundantly present in the cell walls of cereal brans such as rice bran, has recently been suggested to suppress detrusor overactivity when administered orally. However, to the best of our...