Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment? [0.03%]
硫酸脱氢表雄酮在COVID-19的预后和治疗中起作用吗？
Sojit Tomo,Mithu Banerjee,Praveen Sharma et al.
Sojit Tomo et al.
The pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is avail...
Quercetin improves myocardial redox status in rats with type 2 diabetes [0.03%]
黄酮可以改善二型糖尿病大鼠的心肌红氧状态
Nataliia I Gorbenko,Oleksii Yu Borikov,Tetiana V Kiprych et al.
Nataliia I Gorbenko et al.
Objective. Emerging data indicate that oxidative stress is closely associated with the pathogenesis of cardiovascular disease in type 2 diabetes mellitus (T2DM). The present study aimed to assess the effect of the most abundant flavonoid in...
Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis? [0.03%]
甲状腺功能障碍会影响实验性牙周炎的炎症介质吗？
Vitaliy Shcherba,Inna Krynytska,Mariya Marushchak et al.
Vitaliy Shcherba et al.
Objective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between i...
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress [0.03%]
慢性轻度应激大鼠海马和前额皮质BDNF及糖皮质激素受体水平的改变：Haloperidol和Aripiprazole的影响
Jana Osacka,Romana Koprdova,Andrej Tillinger et al.
Jana Osacka et al.
Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild s...
Graves' disease with spontaneous resolution following ocrelizumab in primary progressive multiple sclerosis [0.03%]
在原发进行性多发性硬化症中使用奥克利珠单抗后自身免疫甲状腺疾病自发缓解一例报告
Diana Borges Duarte,Ana Martins da Silva,Claudia Freitas et al.
Diana Borges Duarte et al.
Objectives. Immune reconstitution therapies (IRT), which include antibody-based cell-depleting therapies targeting CD52+ (alemtuzumab) or CD20+ (rituximab, ocrelizumab) leukocytes, are approved for the treatment of multiple sclerosis. Thyro...
Tumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression [0.03%]
肿瘤诱发的骨软化症 - 超越疼痛和抑郁的神秘疾病
Huajing Jing Ni,Roderick Clifton-Bligh,Malgorzata Monika Brzozowska
Huajing Jing Ni
Objective. Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by chronic hypophosphatemia and osteomalacia. We present case of a patient with a protracted clinical course of TIO. TIO profoundly affected every a...
Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes [0.03%]
选择的3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂。在糖尿病前期和二型糖尿病中的应用及潜力一览
Douglas Edward Barre,Kazimiera Amelia Mizier-Barre
Douglas Edward Barre
Objectives. This review assesses the comparative safety and efficacy of selected 3-hydroxy-3-methylglutaric acid coenzyme A inhibitors (statins, cinnamic acids. 3-hydroxy-3-methyl glutaric acid) on the pre-onset type 2 diabetes (PT2D) and p...
ERN1 knockdown modifies the impact of glucose and glutamine deprivations on the expression of EDN1 and its receptors in glioma cells [0.03%]
ERN1敲低改变了葡萄糖和谷氨酰胺剥夺对胶质瘤细胞中EDN1及其受体表达的影响
Dmytro O Minchenko,Olena O Khita,Dariia O Tsymbal et al.
Dmytro O Minchenko et al.
Objective. The aim of the present investigation was to study the impact of glucose and gluta-mine deprivations on the expression of genes encoding EDN1 (endothelin-1), its cognate receptors (EDNRA and EDNRB), and ECE1 (endothelin converting...
The parp-1 and bax genes as potential targets for treatment of the heart functioning impairments induced by type 1 diabetes mellitus [0.03%]
PARP-1和BAX基因作为潜在治疗1型糖尿病引起的心功能障碍靶点
Tamara Kuchmerovska,Mykhailo Guzyk,Tetiana Tykhonenko et al.
Tamara Kuchmerovska et al.
Objectives. The present study was designed to assess whether apoptosis-related genes as parp-1 and bax could be targets for treatment of diabetes mellitus and whether vitamin D may exert beneficial effects. Methods. Vitamin D3 treatment for...
Thyroid hormone and thyroid hormone nuclear receptors: History and present state of art [0.03%]
甲状腺激素和甲状腺激素核受体：历史与现状
Julius Brtko
Julius Brtko
The present review traces the road leading to discovery of L-thyroxine, thyroid hormone (3,5,3´-triiodo-L-thyronine, T3) and its cognate nuclear receptors. Thyroid hormone is a pleio-tropic regulator of growth, differentiation, and tissue ...