Co-amorphization for solubility and dissolution rate improvement: the case of low-crystallization-tendency drugs [0.03%]
共无定形化改善溶解度和溶出速率：低结晶倾向性药物的例子
Arif Budiman,Naila Dwi Rahmaharva,Salma Chiara Putri et al.
Arif Budiman et al.
Poor aqueous solubility and limited oral bioavailability remain major challenges in drug development. Although amorphous forms can improve solubility and dissolution, their physical stability is often compromised by recrystallization. Co-am...
Adherence to evidence-based guidelines for the management of candiduria in a tertiary care center in Riyadh: A retrospective cross-sectional study [0.03%]
利雅得一家三级医疗中心对念珠菌尿症管理循证指南遵循情况的回顾性横断面研究
Mohammed Alessa,Sulaiman Alzunaydi,Hattan Y Alfaqeeh et al.
Mohammed Alessa et al.
According to the Infectious Disease Society of America (IDSA) 2016 guidelines for the management of candidiasis, the presence of Candida in the urine in asymptomatic patients is usually a colonization rather than an infection, which does no...
Phytochemicals with potential NMDAR-inhibitory activities: a review of neuroprotective mechanisms against excitotoxicity [0.03%]
具有潜在NMDAR抑制活性的植物化学成分：针对兴奋性毒性神经保护机制的综述
Abdulmohsin J Alamoudi
Abdulmohsin J Alamoudi
The N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors in the central nervous system (CNS) that play a crucial role in synaptic plasticity, learning, and memory. However, NMDAR overstimulation is a critical pathologi...
Bridging the clinical trial gap in Saudi Arabia: a multi-stakeholder conference-based consensus on strategic initiatives for global competitiveness and patient inclusion [0.03%]
bridging the clinical trial gap in saudi arabia：a multi-stakeholder conference-based consensus on strategic initiatives for global competitiveness and patient inclusionSaudi Arabia临床试验缺口的弥合：基于多利益攸关方会议的全球竞争力和患者包容性的战略举措共识
Majed Al Jeraisy,Eva Turgonyi,Vladimir Misik et al.
Majed Al Jeraisy et al.
Background: The clinical trial ecosystem of Saudi Arabia has advanced significantly, with innovative industry-sponsored clinical trials (iCTs) growing by 27% from 2018 to 2023, reaching 51.4% in the first half of 2025. Ho...
Biogenic chitosan-encapsulated Cu/ZnO nanocomposite surface coating inhibits MDR Pseudomonas aeruginosa biofilm establishment on orthopedic implants [0.03%]
生物活性壳聚糖封装Cu / ZnO纳米复合材料表面涂层可抑制MDR铜绿假单胞菌在骨科植入物上的生物膜形成
Bushra Uzair,Zukhra Abbasi,Fehmida Fasim et al.
Bushra Uzair et al.
Orthopedic implant-associated infections (IAIs), predominantly caused by Pseudomonas aeruginosa, represent a major clinical challenge due to antibiotic resistance and biofilm formation, which together contribute to their chronic nature. Thi...
Huachansu triggers mitochondrial apoptosis and ER stress to inhibit hepatocellular carcinoma progression [0.03%]
华蟾素通过线粒体凋亡和内质网应激抑制肝癌进展
Ximeng Li,Qiuying Yan,Qibiao Wu et al.
Ximeng Li et al.
Huachansu, derived from the dried skin glands of the Chinese toad (Bufo bufo gargarizans), has been used in traditional Chinese medicine for its anti-tumor properties, particularly in hepatocellular carcinoma (HCC). However, its molecular m...
Influence without medical expertise: a social network analysis of Mounjaro discussions on twitter (X) [0.03%]
无医学背景的影响力：对Twitter上Mounjaro讨论的社会网络分析(X)
Saja AlHazmi,Hayam A AlRasheed,Basma Gomaa
Saja AlHazmi
Mounjaro (tirzepatide) is a recently approved medication for type 2 diabetes that is increasingly used off-label for weight loss, in part due to extensive promotion on social media. X has emerged as a major venue for discussions about weigh...
Exploring the pivotal role of hot melt extrusion technology in developing PLGA based novel drug delivery platforms for better therapeutic outcomes [0.03%]
探究热熔挤出技术在开发新型PLGA药物传递平台以获得更好治疗效果方面的重要作用
Mashan Almutairi,Reem Hammad Almuhwes,Joud Abdulkarim Alshammari et al.
Mashan Almutairi et al.
Among various biodegradable polymers, polylactic-co-glycolic acid (PLGA) is one of most widely studied synthetic polymer for controlled and targeted drug delivery. PLGA is a smart polymer as it has stimuli-responsive behaviour. PLGA is appr...
High throughput virtual screening and validation of Plant-Based EGFR L858R kinase inhibitors against Non-Small cell lung Cancer: An integrated approach Utilizing GC-MS, network Pharmacology, Docking, and molecular dynamics [0.03%]
基于植物的EGFR L858R蛋白激酶抑制剂的高通量虚拟筛选及验证：一种集成方法利用气相色谱-质谱、网络药理学、分子对接和动力学模拟对抗非小细胞肺癌
Kun Gao,Zujian Chen,Na Zhang et al.
Kun Gao et al.
Lung cancer ranks as the 2nd most common cancer globally. It's the most prevalent cancer in men and the 2nd most common in women. The prominent events in EGFR-mutated non-small-cell lung cancer (NSCLC) include the emergence of the L858R mut...
Ceftriaxone and MC-100093 mitigate fentanyl-induced cardiac injury in mice: Preclinical investigation of its underlying molecular mechanisms [0.03%]
头孢曲松和MC-100093减轻小鼠芬太尼诱导的心脏损伤：其潜在分子机制的临床前研究
Abdullah F AlAsmari,Mohammed M Alshehri,Nemat Ali et al.
Abdullah F AlAsmari et al.
Drug addiction is considered a worldwide concern and one of the most prevailing causes of death globally. Opioids are highly addictive drugs, and one of the most common opioids that is frequently used clinically is fentanyl. The potential h...