Molecular mechanisms attributed to colistin renal proximal tubular epithelial cytotoxicity [0.03%]
有关多黏菌素肾近曲小管上皮细胞毒性的分子机制
Mohamed A Mahmoud,Metab Alharbi
Mohamed A Mahmoud
Colistin is an antibiotic that belongs to the polymyxin family. It has reemerged as a treatment of last resort against multi-drug resistant gram-negative bacterial infections. Nephrotoxicity remains the most daunting and limiting adverse ef...
Targeting triple-negative breast cancer: apoptotic and antitumor effects of Artemisia sieberi Besser extracts [0.03%]
艾属植物贝塞尔雌青素的细胞毒性及抗肿瘤作用机制研究
Fatimah G Albani,Sahar S Alghamdi,Sabine Matou-Nasri et al.
Fatimah G Albani et al.
Artemisia sieberi Besser (A. sieberi) has shown promise as a natural source of safe cytotoxic agents for breast cancer therapy. However, its effects on triple-negative breast cancer (TNBC), a very aggressive subtype lacking targeted treatme...
Impact of coverage of drug availability regulations across the supply chain cycle in Saudi Arabia [0.03%]
沙特阿拉伯药品供应周期各阶段可及性监管的覆盖面及其影响
Abdulmalik Alyousef,Mohammed Al Masoud,Mohammed Alturki et al.
Abdulmalik Alyousef et al.
There is a need for assessing the impact of current drug availability regulations across the various stages of the pharmaceutical supply chain and among different stakeholders involved. This mixed methods survey assessed the impact of pharm...
Current status and trends of anti-tumor biosimilars in China from 2019 to 2023: A cross-sectional analysis [0.03%]
2019-2023年中国抗肿瘤生物类似药现状与趋势分析：横断面研究
Han Shan,Zihan Guo,Xuan Ye et al.
Han Shan et al.
While several anti-tumor biosimilars have been approved in China, comprehensive nationwide analyses of their real-world utilization patterns remain limited, particularly regarding cross-regional adoption and indication-specific usage. We co...
Effects of sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes and nonalcoholic fatty liver disease: A cohort study [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂对2型糖尿病和非酒精性脂肪肝病患者的影响：一项队列研究
Rania Naguib,Nouran Aleyeidi,Hend Naguib
Rania Naguib
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a novel group of oral medications used to treat type 2 diabetes mellitus (T2DM). Nonalcoholic fatty liver disease (NAFLD), a complication of T2DM, is now recognized as one of the most ...
The association between parenteral antimicrobials and bacterial resistance at King Khaled Hospital in Al-Kharj: A retrospective cohort study [0.03%]
利福赫国王医院抗菌药物暴露与细菌耐药性之间关系的回顾队列研究
Nehad Jaser Ahmed,Zahaa Eid Alrashidi,Ziyad S Almalki et al.
Nehad Jaser Ahmed et al.
Antimicrobial resistance (AMR) is rising alarmingly in Saudi Arabia, as evidenced by surveillance data. This retrospective cohort study evaluated the association between parenteral antimicrobial use and bacterial resistance at King Khaled H...
Baicalin nano-micelles for dry eye disease: LC-MS/MS method validation, pharmacokinetics and pharmacodynamics in preclinical models [0.03%]
临床前模型中的 baicalin 纳米胶束制剂：LC-MS/MS 方法学验证，药代动力学及药效学研究干眼病
Ziheng Wang,Yuchen Xu,Manting Liu et al.
Ziheng Wang et al.
This study aimed to establish a method for quantifying baicalin (BC) in rabbit ocular tissues and plasma, and evaluate the pharmacological efficacy and pharmacokinetic properties of BC and BC@HS15/DSPE-PEG2000-L-Val, a novel ocular formulat...
Therapeutic potential of canagliflozin in DEN/TAA-induced renal cancer: mechanistic insights into NLRP3/IL-6/STAT3 and AMPK signaling and oxidative stress regulation [0.03%]
卡格列净在DEN/TAA诱导的肾癌治疗中的潜力：NLRP3/IL-6/STAT3和AMPK信号通路及氧化应激调节机制研究
Rehab F Abdel-Rahman,Mahdi H Alsugoor,Naif ALSuhaymi et al.
Rehab F Abdel-Rahman et al.
A novel class of antidiabetic drugs known as sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) prevents the renal proximal tubules from reabsorbing glucose. While a recent study showed that SGLT2-Is may be able to slow the proliferation ...
Myocarditis induced by durvalumab in a patient with hepatocellular carcinoma: A case report [0.03%]
肝癌患者接受德瓦鲁单抗导致的心肌炎一例报告
Lama Alfehaid,Nada Alsuhebany,Maha Aldoughaim et al.
Lama Alfehaid et al.
Durvalumab is an immune checkpoint inhibitor that targets PD-L1 and is used for malignancies such as hepatocellular carcinoma. Although effective, it may cause immune-related adverse events, including rare cases of myocarditis (0.06% to 1%)...
Acidifying agents impact erlotinib and gefitinib pharmacokinetic parameters and elevate liver enzymes in Wistar rats [0.03%]
酸化剂对Wistar大鼠厄洛替尼和吉非替尼的药代动力学参数及转氨酶的影响
Amsha S Alsegiani,Aliyah Almomen,Maria Arafah et al.
Amsha S Alsegiani et al.
Erlotinib (ERL) and Gefitinib (GEF) are weakly basic drugs with pH-dependent solubility profiles mainly dependent on stomach pH. We proposed possible drug and/or food-drug interactions with acidifying agents. Citric acid (CA) and phosphoric...