The 40th Minute Cortisol Measurement is the Key Time-Point in the Low-Dose Synacthen Stimulation Test: A Large, Assay-Specific Pediatric Validation Study [0.03%]
皮质醇检测的第40分钟是低剂量合成促肾上腺皮质激素刺激试验的关键时间点：一项大规模、特异于检验方法的儿科验证研究
Busra Gurpinar Tosun,Hazal Arikan Gacemer,Didem Helvacioglu et al.
Busra Gurpinar Tosun et al.
Background: Low-dose synacthen stimulation test (LDSST) is widely used to assess central adrenal insufficiency (CAI). With the adoption of monoclonal antibody (mAb) cortisol immunoassays, lower basal and peak cortisol con...
BMI-SDS Changes During GnRHa Therapy in 150 Girls with Idiopathic Central Precocious Puberty: Follow-up Through Final Height [0.03%]
一项关于GnRHa治疗特发性中枢性早熟女孩的BMI-SDS变化的研究（随访至成年身高）
Didem Helvacıoğlu,Busra Gurpinar Tosun,Sefa Öğe et al.
Didem Helvacıoğlu et al.
Objective: To evaluate longitudinal changes in body mass index standard deviation score (BMI SDS) in girls with central precocious puberty (CPP) treated with gonadotropin-releasing hormone analogues (GnRHa) from treatment...
A Comparative Assessment of Large Language Models in Congenital Hypothyroidism: Reliability, Quality and Readability [0.03%]
先天性甲状腺功能减退症大型语言模型的比较评估：可靠性、质量和可读性
Ebru Barsal Çetiner,Berna Singin
Ebru Barsal Çetiner
Objective: To comparatively evaluate the reliability, quality, and readability of responses generated by widely used large language model (LLM)-based chatbots to congenital hypothyroidism (CH)-related patient questions. ...
Clinical and Genetic Characterization of Noonan Syndrome in a Colombian Pediatric Cohort [0.03%]
哥伦比亚儿童诺伦综合征的临床和基因特征分析
Silvia C Martínez Rueda,Maria Del Pilar Montilla,Carolina Baquero et al.
Silvia C Martínez Rueda et al.
Objective: This study aimed to describe the clinical manifestations and genetic variants of Noonan syndrome in a Colombian pediatric population and to identify the genes most frequently associated with specific phenotypic...
A 13-Year-Old Girl with Congenital Hyperinsulinemic Hypoglycemia Due to an ABCC8 Mutation and Recent Onset of Diabetes Mellitus: A Case Report and Literature Review [0.03%]
一种ABCC8基因突变导致的儿童先天性高胰岛素血症合并糖尿病病例报告及文献复习
Aikaterini Kantzavelou,Ekaterini Siomou,Anny Mertzanian et al.
Aikaterini Kantzavelou et al.
Congenital hyperinsulinism (HI) is the most prevalent cause of persistent hypoglycemia in infancy and childhood and comprises a heterogeneous group of genetic disorders affecting insulin secretion. The most common etiology involves inactiva...
Subclinical Hypothyroidism in Children: Natural History, Risk Factors, and Outcomes [0.03%]
儿童亚临床甲状腺功能减退的自然病程、危险因素及转归
Nur Şeyma Zengin,Elif Sağsak,Seda Geylani Güleç
Nur Şeyma Zengin
Background: Subclinical hypothyroidism (SH) is defined by elevated thyroid-stimulating hormone (TSH) with normal thyroid hormone levels and typically presents without specific symptoms in children. Although treatment crit...
Short Stature and Growth Hormone Deficiency in POMC Deficiency: An Unexpected Clinical Association [0.03%]
黑皮质素原肽缺陷中的矮小和生长激素缺乏：意外的临床联系
Uğur Cem Yılmaz,Deniz Özalp Kızılay,Damla Gökşen et al.
Uğur Cem Yılmaz et al.
Proopiomelanocortin (POMC) deficiency is a rare monogenic obesity syndrome typically characterized by early-onset obesity, red hair, and hypopigmentation, while linear growth is usually preserved. We report an adolescent girl with genetical...
Early Childhood Obesity: Multifactorial Influences with a Prominent Familial Contribution [0.03%]
儿童肥胖：多因素影响及显著的家庭作用
İsmail Hakkı Akbeyaz,Yasemin Akın,Berkin Berk Akbeyaz et al.
İsmail Hakkı Akbeyaz et al.
Background: Early childhood obesity is an increasing public health problem with long-term consequences. Identifying risk factors is essential for effective prevention strategies. ...
Once-Weekly Somatrogon in Pediatric Growth Hormone Deficiency: Real-World Efficacy, Safety, and Quality-of-Life Findings [0.03%]
一周一次somatrogon治疗儿童生长激素缺乏症：真实世界有效性、安全性和生活质量的研究结果
Kübra Şen Küçük,Sebla Güneş,Mustafa Dinçer et al.
Kübra Şen Küçük et al.
Objective: To report real-world 6- and 12-month outcomes in children with growth hormone deficiency (GHD) treated with somatrogon or somatropin, including those who transitioned from somatropin to somatrogon. ...
Late-Onset and Recurrent Agranulocytosis During Low-Dose Methimazole Therapy in an Adolescent with Graves' Disease [0.03%]
格雷夫斯病青少年患者在接受小剂量甲巯咪唑治疗过程中出现晚期粒细胞缺乏症并复发
Betül Demircan Coşkun,Şebnem Yılmaz,Balahan Bora et al.
Betül Demircan Coşkun et al.
Graves' disease (GD) is the most common cause of thyrotoxicosis in the pediatric population. Methimazole (MMI) is the first-line therapy; however, it may rarely cause agranulocytosis, a potentially life-threatening adverse effect. Recurrent...