Oxaliplatin-induced testicular toxicity is associated with transglutaminase-4 upregulation, hormonal dysregulation, and inflammatory responses [0.03%]
奥沙利铂诱导的睾丸毒性与转谷氨酰胺酶-4上调、激素失调和炎症反应有关
Husah M Alowss,Ibtesam S Almami,Heba F Gomaa
Husah M Alowss
Oxaliplatin-induced toxicity presents a major challenge in cancer management because of its damaging effects on normal tissues, including the reproductive system. Transglutaminase 4 (TG4), a member of the transglutaminase enzyme family, is ...
Five-year outcomes of posterior chamber phakic implantable collamer lens implantation in high myopia, keratoconus, and post-keratoplasty eyes [0.03%]
后房有晶状体眼PhakicImplantableCollamerLens植入矫正高度近视、圆锥角膜及角膜移植术后五年效果分析
Iveta Nemcova,Jiri Pasta,Katerina Hladikova et al.
Iveta Nemcova et al.
Purpose: To report on a 5-year follow-up of Implantable Collamer Lenses (ICL) implantation and compare it to previously published iris-fixated phakic intraocular lenses (IF pIOLs). ...
Immunogenic and cross-reactive carbohydrate determinants in ticks and other arthropods [0.03%]
存在于蜱虫及其他节肢动物中的免疫原性及交叉反应性糖基决定簇
Jarmila Sterbova,Libor Grubhoffer,Jan Sterba
Jarmila Sterbova
Ticks are parasites that feed on the blood of humans and animals, using it as their sole source of food. Due to their lifestyle, ticks at each life stage transmit various tick-borne pathogens while feeding on their hosts. Unlike mosquitoes ...
Evidence for bidirectional gut-spleen crosstalk in rodent models: scoping review of possible mechanisms and therapeutic implications [0.03%]
啮齿类动物模型中双向脾胃交互作用的证据：可能机制和治疗意义的综述性回顾研究
Teresa Lucretia,Dewi Kartikawati Paramita,Rina Susilowati
Teresa Lucretia
Introduction: The gut-spleen axis has been proposed to link the gut environment with splenic immune regulation and systemic homeostasis. This scoping review examines this interaction in rodent models. ...
Emerging biomedical and pharmaceutical strategies for the treatment of atherosclerosis: from conventional lipid-lowering therapy to nanomedicine [0.03%]
动脉粥样硬化的生物医学和药物治疗新策略：从传统的降脂疗法到纳米医药
Angelika Mysliwiec,Dawid Leksa,Dorota Bartusik-Aebisher et al.
Angelika Mysliwiec et al.
Atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction and ischemic stroke, is a leading cause of death and disability worldwide and is expected to rise further by 2030. Once limited to industrialized nations, ather...
miR-500a-3p negatively regulates SOCS2 and participates in the proliferation, glycolysis, and apoptosis of HCC cells via the JAK2/STAT5 pathway [0.03%]
miR-500a-3p通过JAK2/STAT5信号通路负向调控SOCS2并参与肝癌细胞增殖、糖酵解及凋亡
Shan Li,Wei Luo,Wei Liu
Shan Li
Background: HCC is a prevalent malignant tumor globally with high mortality. MiR-500a-3p plays critical roles in tumorigenesis and tumor progression. Meth...
Walking the tightrope: Balancing immune checkpoints and their inhibitors in host defence against bacterial infections [0.03%]
走钢丝：在宿主防御细菌感染过程中平衡免疫检查点及其抑制剂
Anna Palounkova,Andrea Frejlachova,Anna Kovarikova et al.
Anna Palounkova et al.
Immune checkpoints are one of the mechanisms that maintain the balance between immunotolerance and immunopathology. These mechanisms are often exploited by tumour cells. Thanks to extensive global testing of anticancer drugs, a revolutionar...
Relationship between interleukin-37 genetic polymorphisms and HBV-related liver disease in a Chinese Han cohort [0.03%]
汉族人群中白细胞介素37基因多态性与乙肝相关肝病的关系研究
Ping Fang,Ping Meng,Lijun Du et al.
Ping Fang et al.
Hepatitis B virus (HBV)-related liver disease is an inflammatory-associated disease, with diverse clinical phenotypes ranging from asymptomatic HBV carriers to hepatocellular carcinoma. Interleukin-37 (IL-37), a cytokine that effectively in...
Propofol suppresses breast cancer invasion: An in vitro three-dimensional cell invasion model with microfluidic technology [0.03%]
异丙酚通过微流体三维模型抑制乳腺癌侵袭
Zhitong Wan,Haoyue Lyu,Yuting Luo et al.
Zhitong Wan et al.
The fundamental aspect of breast cancer metastasis is the infiltration of malignant cells, which can be blocked by propofol, a widely utilized anesthetic in clinical settings, as recent studies reporting. However, research utilizing three-d...
Exosomes from LPS-stimulated macrophages alleviate neuroinflammatory responses by reducing pyroptosis in systemic lipopolysaccharide-induced mice [0.03%]
LPS刺激的巨噬细胞来源的外泌体通过减少系统性脂多糖诱导的小鼠神经炎症反应中的pyroptosis来缓解神经炎症反应
Tao Ying,Zhezhe Sun
Tao Ying
Central nervous system (CNS) inflammation occurs in cognitive dysfunction, but the underlying mechanisms remain unclear. The newly discovered pattern of cell death in recent years is called pyroptosis, which is distinguished from apoptosis ...