A novel mouse model of pulmonary fibrosis: twice-repeated oropharyngeal bleomycin administration mimicking human pathology [0.03%]
一种新的肺纤维化小鼠模型：重复的咽部博来霉素给药模仿人类病理过程
Jingyu Wang,Fengqing Zhu,Yuxuan Liu et al.
Jingyu Wang et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with high mortality and limited treatment options. While single-dose bleomycin-induced models are commonly used to investigate the pathogenesis of IPF, they ...
Efficacy of lactoferrin supplementation in pediatric infections: A systematic review and meta-analysis [0.03%]
乳铁蛋白补充剂在儿科感染中的疗效：系统评价和荟萃分析
Valerie S Mayorga,Rafaella Navarro,Victor D Torres Roldan et al.
Valerie S Mayorga et al.
Pediatric infections account for approximately one-third of all deaths in children under 5 globally. Lactoferrin (LF) supplementation has the potential to reduce infection-related morbidity due to its antimicrobial, anti-inflammatory and im...
Nikolas F Ewasechko,David M Curran,Ken Yu Khaw et al.
Nikolas F Ewasechko et al.
Surface receptors in Gram-negative bacteria that bind and extract iron from the host glycoproteins transferrin (Tf) or lactoferrin (Lf) was discovered 35 years ago in pathogenic Neisseria species and subsequently was discovered in other pat...
LMAN2 interacts with HEATR3 to expedite HER2-positive breast cancer advancement and inflammation and Akt/ERK/NF-κB signaling [0.03%]
LMAN2通过加速HER2阳性乳腺癌的进展和炎症以及Akt/ERK/NF-κB信号传导与HEATR3相互作用
Sujian Xiao,Tong Yu,Fulan Yang et al.
Sujian Xiao et al.
The paper aimed to reveal the impacts and the possible mechanism of action of lectin mannose-binding 2 protein (LMAN2) in HER2-positive breast cancer (BC). The expression, prognostic potential of LMAN2, and the correlation between LMAN2 and...
Multifaceted Roles of MeCP2 in Cellular Regulation and Phase Separation: Implications for Neurodevelopmental Disorders, Depression, and Oxidative Stress [0.03%]
MeCP2在细胞调控和相分离中的多面作用：对神经发育障碍、抑郁症和氧化应激的启示
Katrina Good,Ladan Kalani,John Vincent et al.
Katrina Good et al.
Methyl CpG binding protein 2 (MeCP2) is a chromatin-associated protein that remains enigmatic despite more than 30 years of research, primarily due to the ever-growing list of its molecular functions, and, consequently, its related patholog...
Ischemia-Induced Expression Status of Cofilin 1, CRSP2, HSP90, HSP27, and IL-8 in Epicardial Adipose Tissue and Single Cell Transcriptomic Profiling of Stromal Cells [0.03%]
心肌缺血诱导下冠状脂肪组织中Cofilin 1、CRSP2、HSP90、HSP27和IL-8表达状态及基质细胞单细胞转录组学分析
Ed Cha,Sung Ho Hong,Vy La et al.
Ed Cha et al.
Epicardial adipose tissue (EAT) is a rich source of EAT-derived stromal cells (EATDS) which possess regenerative potential. CRSP2, HSP27, IL8, HSP90 and Cofilin 1 were detected in the secretome of left ventricular stromal cells under ischem...
TRIM3 modulates cisplmatin-resistant of cervical squamous cell carcinoma via endoplasmic reticulum stress signaling in vitro [0.03%]
TRIM3通过内质网应激信号调节体外宫颈鳞癌顺铂耐药性
Meiya Mao,Tianzi You,Kejun Xu et al.
Meiya Mao et al.
TRIM3 is widely recognized as a tumor suppressor gene. However, its precise role in cervical squamous cell carcinoma (CESC) remains elusive. Here, we observed a significant decrease in the expression of TRIM3 in CESC cells. Overexpression o...
Artificial intelligence in academia: opportunities, challenges, and ethical considerations [0.03%]
学术界的人工智能：机遇、挑战及伦理思考
Joshua Molligan,Edel Pérez-López
Joshua Molligan
E2F8 facilitates malignant phenotypes of muscle-invasive bladder cancer via increasing MCM7 expression [0.03%]
E2F8通过增加MCM7表达促进肌层浸润性膀胱癌的恶性表型
Li-Yun Liu,Liang Tian,Ling-Huan Gao et al.
Li-Yun Liu et al.
E2F transcription factor 8 (E2F8) is an important regulator of the cell cycle. In this study, we first assessed the expression of E2F8 in bladder cancer and examined its effects in the malignant phenotypes of bladder cancer cell lines. We f...