Diphenoquinone, a Small-HDL Neogenesis Accelerator, Concurrently Docks with Cholesterol or POPC to Human ATP-binding Cassette Transporter ABCA1 [0.03%]
一种新的小分子HDL激活剂茋醌可同时与胆固醇或POPC结合并激活ABCA1转运蛋白的功能
Maki Tsujita,Leticia Alves Da Silva,Kosuke Nakasuka et al.
Maki Tsujita et al.
High-density lipoprotein (HDL) functionality has emerged as a key determinant of residual cardiovascular risk despite advances in LDL-cholesterol lowering therapies. Small HDL particles, generated through ATP-binding cassette transporter A1...
Autologous chylous fat improves hypertrophic scars via TSG-6: association with endoplasmic reticulum stress mediated by IRE1α phosphorylation and JNK activation [0.03%]
自体乳糜脂肪通过TSG-6改善增生性疤痕：与IRE1α磷酸化和JNK活化的内质网应激介导相关
Xingwang Deng,Hongwei Ma,Wenjing Pang et al.
Xingwang Deng et al.
Hypertrophic scars (HS) represent pathological outcomes of traumatic or surgical injuries with dysregulated wound healing. We investigated the therapeutic effects and underlying mechanism of autologous chyle fat (ALCF) in HS formation. A th...
Beyond phenylalanine to tyrosine: Mapping the comprehensive phenylalanine hydroxylase (PAH) pathway for systems biology [0.03%]
从苯丙氨酸到酪氨酸：用于系统生物学的苯丙氨酸羟化酶(PAH)通路全面图谱
Sophia M Khan,Madison L Fennell,Elizabeth Kandiotis et al.
Sophia M Khan et al.
The phenylalanine hydroxylase (PAH) pathway is an enzymatic pathway focused primarily on the hydroxylation of the amino acid L-phenylalanine (Phe) to L-tyrosine (Tyr). However, the functioning of this pathway can also have significant impac...
Broad-Stroke Regulation by DNA Sequence-Specific Transcription Factors [0.03%]
特异性识别DNA序列的转录因子通过大范围调控影响基因表达
Zachary Bigelow,Sergei Nechaev
Zachary Bigelow
Sequence-specific transcription factors (TFs) regulate gene expression in all living organisms. An established function of TFs is to activate or repress transcription of target genes by binding to specific DNA sequence motifs at their promo...
Reply to the discussion of "Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and metanalysis" [0.03%]
乳铁蛋白补充治疗儿科感染的有效性：系统评价和meta分析——短评回复
Victor D Torres Roldan,Valerie S Mayorga,Rafaella Navarro et al.
Victor D Torres Roldan et al.
Discussion of "Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and meta-analysis" [0.03%]
乳铁蛋白补充对儿童感染疗效的系统评价和meta分析讨论
Graziella D&#x;Arrigo,Mercedes Gori
Graziella D&#x;Arrigo
Does the beta subunit of mitochondrial trifunctional protein modulate monolysocardiolipin acylation to cardiolipin? [0.03%]
线粒体三功能蛋白的β亚基能否调节单脂酰肉碱-卡脂酰转移酶作用形成.cardiolipin？
Grant Hatch
Grant Hatch
The alpha subunit of mitochondrial trifunctional protein (αTFP) catalyzes the acylation of monolysocardiolipin (MLCL) to cardiolipin (CL). We determined whether the beta subunit of mitochondrial trifunctional protein (βTFP) impacted the a...
Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel [0.03%]
人类HCN4通道疾病相关突变对环核苷酸负协同作用结合的不同影响
Leo Ng,Joanna Xia,Filip Van Petegem et al.
Leo Ng et al.
The direct binding of cAMP to the hyperpolarization-activated cyclic nucleotide-gated channel form 4 (HCN4) protein contributes to autonomic modulation of heart rate. Here, we determine affinity for binding of cyclic nucleotides directly to...
PPP2R2B targets the JAK2-STAT3 signaling pathway to regulate ferroptosis in breast cancer cells [0.03%]
PPP2R2B靶向JAK2-STAT3信号通路调节乳腺癌细胞铁死亡
Weiming Luo,Mei Yang,Yue Tan et al.
Weiming Luo et al.
We aimed to explore the effect and the mechanism of PPP2R2B on cell proliferation, migration, and ferroptosis in breast cancer cells. By bioinformatic analysis and data mining, PPP2R2B was associated with the prognosis and ferroptosis of br...
Suppression of CBP/p300 induces growth inhibition and autophagy of hepatocellular carcinoma cells through regulation of EPHA2 by its super-enhancer acetylation [0.03%]
CBP/p300的抑制通过表观遗传调控EPHA2表达诱导肝癌细胞生长抑制及自噬
Lishan Xi,Bodi Zhang,Bei Lan
Lishan Xi
CREB binding protein (CBP) and its homolog E1A binding protein p300 (p300) are crucial lysine acetyltransferases that have been shown to play key roles in various human malignancies. However, the precise functions and regulatory mechanisms ...