Reply to the discussion of "Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and metanalysis" [0.03%]
乳铁蛋白补充治疗儿科感染的有效性：系统评价和meta分析——短评回复
Victor D Torres Roldan,Valerie S Mayorga,Rafaella Navarro et al.
Victor D Torres Roldan et al.
Discussion of "Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and meta-analysis" [0.03%]
乳铁蛋白补充对儿童感染疗效的系统评价和meta分析讨论
Graziella D&#x;Arrigo,Mercedes Gori
Graziella D&#x;Arrigo
Does the beta subunit of mitochondrial trifunctional protein modulate monolysocardiolipin acylation to cardiolipin? [0.03%]
线粒体三功能蛋白的β亚基能否调节单脂酰肉碱-卡脂酰转移酶作用形成.cardiolipin？
Grant Hatch
Grant Hatch
The alpha subunit of mitochondrial trifunctional protein (αTFP) catalyzes the acylation of monolysocardiolipin (MLCL) to cardiolipin (CL). We determined whether the beta subunit of mitochondrial trifunctional protein (βTFP) impacted the a...
Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel [0.03%]
人类HCN4通道疾病相关突变对环核苷酸负协同作用结合的不同影响
Leo Ng,Joanna Xia,Filip Van Petegem et al.
Leo Ng et al.
The direct binding of cAMP to the hyperpolarization-activated cyclic nucleotide-gated channel form 4 (HCN4) protein contributes to autonomic modulation of heart rate. Here, we determine affinity for binding of cyclic nucleotides directly to...
PPP2R2B targets the JAK2-STAT3 signaling pathway to regulate ferroptosis in breast cancer cells [0.03%]
PPP2R2B靶向JAK2-STAT3信号通路调节乳腺癌细胞铁死亡
Weiming Luo,Mei Yang,Yue Tan et al.
Weiming Luo et al.
We aimed to explore the effect and the mechanism of PPP2R2B on cell proliferation, migration, and ferroptosis in breast cancer cells. By bioinformatic analysis and data mining, PPP2R2B was associated with the prognosis and ferroptosis of br...
Suppression of CBP/p300 induces growth inhibition and autophagy of hepatocellular carcinoma cells through regulation of EPHA2 by its super-enhancer acetylation [0.03%]
CBP/p300的抑制通过表观遗传调控EPHA2表达诱导肝癌细胞生长抑制及自噬
Lishan Xi,Bodi Zhang,Bei Lan
Lishan Xi
CREB binding protein (CBP) and its homolog E1A binding protein p300 (p300) are crucial lysine acetyltransferases that have been shown to play key roles in various human malignancies. However, the precise functions and regulatory mechanisms ...
An optimized protocol for identifying S-acylated proteins in Dictyostelium discoideum [0.03%]
优化的Dictyostelium discoideum中识别S-酰化蛋白质协议
Samer A Owiar,William David Kim,Robert Joseph Huber
Samer A Owiar
S-palmitoylation is a reversible post-translational modification that adds palmitic acid onto cysteine residues of proteins through the formation of a thioester bond. The reaction is catalyzed by protein acyl transferases (PATs) and reverse...
Fan Du,Maotian Wang,Siyu Ji
Fan Du
Caspases are well recognized and studied as the central executioners of apoptosis, while recent studies have unraveled their diverse roles beyond cell apoptotic function.One emerging area of interest is non-apoptotic caspase activity as a p...
Eric Hawrylyshyn,Marcia Ferraz,Biankha Chan et al.
Eric Hawrylyshyn et al.
Somatic cell-based reproductive technologies (SCRTs) offer a promising approach for preserving the genetic diversity of threatened species. SCRTs require the nuclear reprogramming of a donor somatic cell, which has low success rates (1-5%) ...
Terpenes as Modulators of Nociceptive Signaling: Behavioral and Molecular Insights from Caenorhabditis elegans [0.03%]
来源于秀丽隐杆线虫的行为和分子研究揭示单萜通过调节痛觉信号传递止痛的新机制
Kaoutar Benkhraba,Fatma Boujenoui,Jesus David Castaño et al.
Kaoutar Benkhraba et al.
Terpenes such as Limonene (LIMO) and β-Caryophyllene (BC) have demonstrated pain-modulating properties, potentially through interactions with the TRPV1 receptor. This study examines the antinociceptive effects of four terpenes derived from...