Computational Screening of Filamin Mechanical Binding Proteins using AlphaFold2 [0.03%]
使用AlphaFold2计算筛选肌连蛋白机械结合蛋白
Jennifer Johnson,Nicanor González-Morales
Jennifer Johnson
Filamins are dimeric actin binding protein that play a critical role in mechanical signaling. They contain a mechanosensory region (MSR) that naturally folds into a globular closed conformation. Under mechanical stress, the MSR unfolds into...
Divergent ERα Co-factor Landscapes in Gynecological Cancers: Implications for Disease Progression and Therapy [0.03%]
妇科癌症中发散的雌激素受体α共调节因子景观：对疾病进展和治疗的意义
Jenna Grindeland,Jasper Yang,Jerome Yang et al.
Jenna Grindeland et al.
Estrogen receptor alpha (ERα) is an established biomarker for breast tumors, the loss of which is associated with poor cancer progression. Over 70% of breast cancers express ERα and targeting this protein has helped stem the progress of b...
CDHR5 splice isoform cooperation promotes apical targeting of the brush border cadherin [0.03%]
CDHR5拼接异构体协同作用促进刷状缘粘附分子的顶面靶向定位
Samaneh Matoo,Prashun Acharya,Sadika Tul-Jannat Tonu et al.
Samaneh Matoo et al.
Cadherin-related family member 5 (CDHR5) is an adhesion molecule that is highly enriched in the microvilli found on the surface of transporting epithelial cells of the gut and kidney. CDHR5 localizes to the distal tips of these microvilli a...
Zyxin directly binds to chromosomal DNA and is linked with mitochondrial integrity and apoptosis [0.03%]
Zyxin直接结合染色体DNA并连接线粒体完整性和凋亡
M Quadir Siddiqui,Marcin Wojewodzic,Shridhar Sanghvi et al.
M Quadir Siddiqui et al.
Human zyxin is a key component of the focal adhesion complex, playing a role in mediating cell-cell adhesion and cytoskeletal dynamics. Moreover, zyxin shuttles between the cytoplasm and the nucleus, where it contributes to regulating gene ...
Mitotic Bookmarking Provides Epigenetic Persistence or Plasticity for Biological Control and Cancer [0.03%]
有丝分裂书签作用赋予表观遗传稳定性或可塑性以调控生物学及癌症发生发展的作用机制
Andrew J Fritz,Emory Pacht,Rabail H Toor et al.
Andrew J Fritz et al.
Mitotic bookmarking, the retention of regulatory proteins and lncRNAs on chromatin during mitosis, epigenetically sustains competency for phenotype-specific gene expression in progeny cells. Gene expression is predominantly suppressed durin...
KREMEN2 promotes the proliferation and the metastasis through activating PI3K/AKT/mTOR signaling pathway in non-small cell lung cancer [0.03%]
KREMEN2通过激活PI3K/AKT/mTOR信号通路促进非小细胞肺癌的增殖和转移
Shunying Wang,Li Li,Wenming Wang
Shunying Wang
Our purpose was to explore the role and regulatory mechanisms of kringle containing transmembrane protein 2 (KREMEN2) in the development and progression of non-small cell lung cancer (NSCLC). KREMEN2 expression levels were higher in NSCLC t...
Targeting PINK1 using phytochemicals: Exploring molecular insights into Parkinson's disease therapeutics [0.03%]
利用植物化学物质靶向PINK1：探索帕金森病治疗的分子见解
Saranya Nallusamy,Selva Babu Selvamani,Chakkarai Sathyaseelan et al.
Saranya Nallusamy et al.
Parkinson's disease (PD) is one of the most commonly affecting neurodegenerative disorder prevalent in our society. The inherited autosomal recessive PD/parkinsonism occurs due to mutations in six genes including the gene for PTEN (phosphat...
TRAF7 inhibits proliferation and migration of esophageal squamous cell carcinoma by ubiquitination-mediated degradation of SOX12 [0.03%]
泛素介导SOX12降解的TRAF7通过抑制食管鳞癌增殖和迁移的作用机制研究
Guobin Xie,Ning Wang,Yunhe Huang et al.
Guobin Xie et al.
Tumor necrosis factor receptor-associated factor 7(TRAF7), a member of the tumor necrosis factor receptor (TNF-R) superfamily, is known as an E3 ubiquitin ligase and has been shown to contribute to the progression of various cancers. Howeve...
Quercetin alleviates the progression of chronic rhinosinusitis by affecting nasal mucosal epithelial remodeling, inflammation and Treg/Th17 imbalance [0.03%]
槲皮素通过影响鼻黏膜上皮重塑、炎症和Treg/Th17失衡来缓解慢性鼻窦炎的发展进展
Xiaopeng Qu,Pengyu Tao,Jiajia Dong et al.
Xiaopeng Qu et al.
Nasal mucosal epithelial tissue remodeling and persist inflammation are related to the development of chronic rhinosinusitis (CRS). Quercetin possesses multiple biological properties in several inflammatory diseases. However, its roles in C...
Proceedings of the Canadian Society for Molecular Biosciences (CSMB) 2024 Conference - Gene Regulation: From Cells to Systems [0.03%]
加拿大分子生物学会(CSMB) 2024年大会 proceedings - 从细胞到系统的基因调控
Mojgan Rastegar,Hans-Joachim Wieden,James R Davie
Mojgan Rastegar
The 67th Canadian Society for Molecular Biosciences (CSMB) Annual Conference took place in Winnipeg, Manitoba, from 6 May to 8 May 2024, at the University of Manitoba, Winnipeg. The conference theme "Gene Regulation: From Cells to Systems" ...