miR-20b-5p inhibits inflammation-induced endoplasmic reticulum stress through EIF2S1 and promotes osteogenic differentiation of bone marrow mesenchymal stem cells [0.03%]
miR-20b-5p通过抑制炎症诱导的内质网应激促进骨髓间充质干细胞成骨分化
Zhipeng Pan,Qingsen Zhao,Piao Li et al.
Zhipeng Pan et al.
The process of osteogenic differentiation plays a crucial role in the development and mending of bones. Additionally, miRNAs play a crucial role in controlling osteogenic differentiation. The purpose of this study was to investigate the imp...
Shaghayegh Nouruzi,Sabrina Grégoire,Mathieu Lupien et al.
Shaghayegh Nouruzi et al.
The latest research on epigenetics in health and disease was reported at the 10 th Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC) annual meeting at Blue Mountain Resort in Ontario in October, 2024. Canadian and in...
SOX2 TRANSCRIPTIONAL REGULATION BY ENHANCER ELEMENTS: A COMPREHENSIVE REVIEW WITH A UNIFIED ENHANCER NOMENCLATURE [0.03%]
SOX2的增强子调控：综合评论及统一命名法
Mariia Cherednychenko,Natalia A Gajewska,Jennifer A Mitchell
Mariia Cherednychenko
Transcription factor SOX2 is essential for a number of biological processes, including mammalian nervous system development and adult brain stem cell maintenance. Expression of this gene requires precise control by a complex network of regu...
NCOR1 alleviates myocardial infarction by improving lipid peroxidation through PPARG/PINK1-mediated mitophagy [0.03%]
NCOR1通过PPARG/PINK1介导的线粒体自噬改善脂质过氧化从而缓解心肌梗死
Zhenzhen Liu,Yanru He,Wenjing Zhu
Zhenzhen Liu
Abnormal lipid accumulation following myocardial infarction (MI) serves as a critical pathological factor contributing to cardiomyocyte injury. The nuclear receptor corepressor 1 (NCOR1) is famous as a key regulator in atherosclerosis, fatt...
In vitro and in vivo anticancer efficacy of the combination of Actinomycin D and resveratrol [0.03%]
阿特莫西林D和白藜芦醇联合抗肿瘤的体内外实验研究
Lukmon M Raji,Rejina Afrin,Jihan Ferdaus Amin et al.
Lukmon M Raji et al.
Actinomycin D (Act D) was the first FDA-approved anticancer antibiotic. However, its widespread application was hindered by dose-limiting toxicities. In the current study, we investigated the in vitro and in vivo anticancer efficacy of the ...
Geneveve Analike,Dhanvi Prajapati,James R Davie et al.
Geneveve Analike et al.
Acid extraction has been and remains one of the most widely used methods for preparing histones. Over the years, dilute hydrochloric or sulfuric acid solutions have been used alternately for histone extraction, followed by acetone or trichl...
The role of NEDD4L in metabolic dysfunction-associated fatty liver disease (MAFLD) by regulating ferroptosis via deubiquitinating the TGF-β receptor TβRII [0.03%]
NEDD4L通过去泛素化转化生长因子-β受体TβRII调节铁死亡在代谢失调相关脂肪肝病（MAFLD）中的作用
Fang Li,Jiayi Yao,Jianhua Yao et al.
Fang Li et al.
We explored the mechanism of E3 ubiquitin ligase neural precursor cell expressed developmentally down regulated 4-like protein (NEDD4L) mediating ferroptosis sensitivity through the transforming growth factor-beta1 (TGF-β1) signaling to re...
USP54 regulates the malignancy and autophagy in nasopharyngeal cancer cells by modulating ULK1 ubiquitination levels [0.03%]
USP54通过调节ULK1泛素化水平调控鼻咽癌细胞恶性进展和自噬
Fanrui Fu,Yong Wu,Peilin Wang et al.
Fanrui Fu et al.
Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with poor outcomes at advanced stages. Although ubiquitination is critical in regulating oncogenic pathways, the role of many ubiquitin-specific proteases (USPs) in NPC remains unex...
Correction: Evaluation of drug-free methods for the detection of gene silencing in S. cerevisiae [0.03%]
关于用于评估基因沉默的无药物检测方法在酿酒酵母中的性能的更正文章
Kholoud Shaban,Safia Mahabub Sauty,Ashley Fisher et al.
Kholoud Shaban et al.