Alteration of high-density lipoprotein functionality in Alzheimer's disease patients [0.03%]
阿尔茨海默病患者高密度脂蛋白功能改变
Paméla Camponova,Aurélie Le Page,Hicham Berrougui et al.
Paméla Camponova et al.
The aims of the present study were to determine whether high-density lipoprotein (HDL) functionality-mediated cholesterol efflux is altered in Alzheimer's disease and to investigate the role and effect of amyloid-beta (Aβ) in the regulatio...
Kallikrein-kinin system as the dominant mechanism to counteract hyperactive renin-angiotensin system [0.03%]
激活性过强的肾素血管紧张素系统的抗衡机制——以激肽释放酶-激肽系统为主导
Domenico Regoli,Fernand Gobeil
Domenico Regoli
The renin-angiotensin system (RAS) generates, maintains, and makes worse hypertension and cardiovascular diseases (CVDs) through its biologically active component angiotensin II (Ang II), that causes vasoconstriction, sodium retention, and ...
Lingonberry anthocyanins protect cardiac cells from oxidative-stress-induced apoptosis [0.03%]
越桔花青素能保护心脏细胞免受氧化应激诱导的细胞凋亡作用的影响
Cara K Isaak,Jay C Petkau,Heather Blewett et al.
Cara K Isaak et al.
Lingonberry grown in northern Manitoba, Canada, contains exceptionally high levels of anthocyanins and other polyphenols. Previous studies from our lab have shown that lingonberry anthocyanins can protect H9c2 cells from ischemia-reperfusio...
Mechanisms of spontaneous pacing: sinoatrial nodal cells, neonatal cardiomyocytes, and human stem cell derived cardiomyocytes [0.03%]
窦房结细胞、新生儿心肌细胞和人类干细胞分化的心肌细胞的自动去极化机制
Martin Morad,Xiao-Hua Zhang
Martin Morad
The sinoatrial (SA) node is the primary site from which the mammalian heart is paced, but the mechanisms underlying the pacemaking still remain clouded. It is generally believed that the hyperpolarization-activated current If, encoded by hy...
Induced pluripotent stem-cell-derived cardiomyocytes: cardiac applications, opportunities, and challenges [0.03%]
诱导多能干细胞源性心肌细胞：心脏应用、机遇与挑战
Adrien Moreau,Mohamed Boutjdir,Mohamed Chahine
Adrien Moreau
Chronic diseases are the primary cause of mortality worldwide, accounting for 67% of deaths. One of the major challenges in developing new treatments is the lack of understanding of the exact underlying biological and molecular mechanisms. ...
Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in isolated rat hearts: a novel cardioprotective intervention [0.03%]
分子氢增强缺氧心后处理的抗梗死效应：一种新的心脏保护干预措施
Marek Zálešák,Branislav Kura,Ján Graban et al.
Marek Zálešák et al.
Generation of free radicals through incomplete reduction of oxygen during ischemia-reperfusion (I/R) is well described. On the other hand, molecular hydrogen (H2) reduces oxidative stress due to its ability to react with strong oxidants and...
Geraniol promotes functional recovery and attenuates neuropathic pain in rats with spinal cord injury [0.03%]
牻牛儿醇促进脊髓损伤大鼠功能恢复和缓解神经病理性疼痛
Yan Lv,Liang Zhang,Na Li et al.
Yan Lv et al.
Geraniol, a plant-derived monoterpene, has been extensively studied and showed a wide variety of beneficial effects. The aim of this study was to investigate the therapeutic effect of geraniol on functional recovery and neuropathic pain in ...
Behavioral and neurochemical effects of alpha lipoic acid associated with omega-3 in tardive dyskinesia induced by chronic haloperidol in rats [0.03%]
硫利达嗪诱导的慢性氯丙嗪致迟发性运动障碍的行为和神经化学变化及α型焦谷酸与ω-3的相关作用
Dayane Pessoa de Araújo,Thaisa Gracielle Martins Camboim,Ana Patrícia Magalhães Silva et al.
Dayane Pessoa de Araújo et al.
Tardive dyskinesia (TD) is characterized by involuntary movements of the lower portion of the face being related to typical antipsychotic therapy. TD is associated with the oxidative imbalance in the basal ganglia. Lipoic acid (LA) and omeg...
Hepatoprotective effect of blocking N-methyl-d-aspartate receptors in male albino rats exposed to acute and repeated restraint stress [0.03%]
N-甲基-D-天冬氨酸受体拮抗剂对急性及反复束缚应激所致雄性 Wistar 封闭群大鼠肝保护作用研究
Shaimaa Nasr Amin,Ahmed Amro El-Aidi,Maha Baligh Zickri et al.
Shaimaa Nasr Amin et al.
Stress affects many organs in addition to the brain, including the liver. We assessed the effects on the liver of blocking N-methyl-d-aspartate (NMDA) glutamate receptors with memantine in acute and repeated restraint stress. Forty-two male...
Active immunization against transforming growth factor beta1 prevents hepatic fibrosis in a rat model of liver disease [0.03%]
针对TGF-β1的主动免疫在肝病大鼠模型中预防肝纤维化的作用
Hong Ji,Gerald Y Minuk,Zhikang Peng et al.
Hong Ji et al.
Transforming growth factor beta1 (TGF-β1) plays an important role in hepatic fibrogenesis. In this study, we documented the effects of active immunization against TGF-β1 on hepatic fibrosis in an animal model of chronic liver disease. BAL...