Deferoxamine alleviates brain ischemia/reperfusion injury through decreasing LAG-3 and α-Syn expression [0.03%]
去铁敏通过降低LAG-3和α-突触核蛋白的表达缓解脑缺血再灌注损伤
Amany Mansour,Mahmoud R Abdel Fadeil,Ahmed Shoyb Mohamed et al.
Amany Mansour et al.
Ischemic stroke is characterized by brain tissue iron accumulation. Alpha-synuclein (α-Syn) is a neuronal protein, its overexpression in ischemic stroke triggers apoptosis. Lymphocyte activation gene-3 (LAG-3), a receptor for α-Syn, enhan...
New hypoglycemic effects of indorenate mediated by the 5-HT1a and 5-HT2a receptors: In vivo and In silico studies [0.03%]
索拉非那的降糖作用：体内和计算机模拟研究
Abraham Giacoman-Martínez,Julio César Almanza-Perez,Francisco Javier Alarcón-Aguilar et al.
Abraham Giacoman-Martínez et al.
The treatment of metabolic syndrome (MS), characterized by type 2 diabetes (T2D), obesity, dyslipidemias, and cardiovascular problems, requires integral treatment. In addition to its central activity, serotonin also has peripheral effects, ...
Untangling the Heart-Brain Connection in Parkinson's Disease: Emerging Mechanisms and Models [0.03%]
解构帕金森病的心身关联：新兴机制与模型研究
Alessandra Martello,Vincenzo Lionetti
Alessandra Martello
Cardiovascular autonomic dysfunction (CVAD) is a prevalent yet underrecognized non-motor manifestation of Parkinson's disease (PD) that adversely affects morbidity, prognosis, and quality of life. Framed by the heart-brain axis, this review...
Investigating the combined effects of jadomycin B and celecoxib against triple-negative breast cancer using zebrafish larval xenografts [0.03%]
利用斑马鱼癌胚移植模型研究Jadomycin B和Celecoxib联合抗三阴性乳腺癌的协同作用机制
Hailey Stack,Michael Morash,Brendan T McKeown et al.
Hailey Stack et al.
Breast cancer affects 1 in 8 Canadian women over their lifetime. Triple-negative breast cancer (TNBC) represents 10-20% of all advanced stage breast cancers, often developing multi-drug resistance (MDR), commonly resulting in treatment fail...
Myosin Inhibitors for the Treatment of Obstructive Hypertrophic Cardiomyopathy: A Canadian Perspective on a First-in-Class Therapy [0.03%]
梗阻性肥厚型心肌病治疗药物新进展——从加拿大视角看首创肌球蛋白抑制剂疗法的前景与挑战
Wesley Chee Yeung Lau,Saif Dababneh,Kevin Ong et al.
Wesley Chee Yeung Lau et al.
Hypertrophic cardiomyopathy (HCM) is a relatively common heritable cardiac condition (~1 in 500) that can significantly reduce quality and quantity of life. Severe symptoms are often from dynamic left ventricular outflow tract (LVOT) obstru...
Sex-Specific Effects of Abdominal Aortic Constriction on Renal Cytochrome P450 Enzymes and Arachidonic Acid Metabolites in Male and Female Rats [0.03%]
不同性别的大鼠腹主动脉狭窄对肾脏细胞色素P450酶及花生四烯酸代谢物的影响不同
Samar H Gerges,Sara A Helal,Heidi L Silver et al.
Samar H Gerges et al.
We previously showed that male rats develop more severe cardiac hypertrophy than female rats following abdominal aortic constriction (AAC), and highlighted corresponding changes in cardiac cytochrome P450 (CYP) enzymes and their arachidonic...
Correction: Deciphering MMP9's dual role in regulating SOD3 through protein-protein interactions [0.03%]
关于纠正MMP9通过蛋白质-蛋白质相互作用调节SOD3的双重作用的解读
Flobater I Gawargi,Paras K Mishra
Flobater I Gawargi
Published Erratum
Canadian journal of physiology and pharmacology. 2025 Nov 12. DOI:10.1139/cjpp-2025-0306 2025
Correction: Polygenic scores of obesity in childhood based on summary statistics from adults versus children [0.03%]
纠正：基于成人汇总统计的儿童肥胖多基因评分与基于儿童汇总统计的肥胖多基因评分的区别
Danick Goulet,Michel Boivin,Christopher Gravel et al.
Danick Goulet et al.
Published Erratum
Canadian journal of physiology and pharmacology. 2025 Nov 5. DOI:10.1139/cjpp-2025-0305 2025
Clinical diagnostic criteria for cardiogenic shock should be based on pathophysiology [0.03%]
心源性休克的临床诊断标准应基于病理生理学
Petr Ostadal
Petr Ostadal
Cardiogenic shock is a clinical syndrome characterized by cardiac pump failure, resulting in low cardiac output and subsequent tissue hypoperfusion. Current guidelines define cardiogenic shock based on the presence of hypotension and signs ...
Izabela Quest,Marek Michalak
Izabela Quest
Aging is a process characterized by the progressive decline in physiological function and increased susceptibility to disease. Many cellular functions, including unfolded protein responses (UPR, an endoplasmic reticulum (ER) stress coping m...