Cost-Effectiveness of Incretin Therapies: A Canadian Lens on Diabetes, Obesity, and Emerging Indications [0.03%]
从加拿大视角看 incretin 治疗的性价比：糖尿病、肥胖症及其新适应证的角度
Luke Awadalla,Siena Iskander,Cherry Chu et al.
Luke Awadalla et al.
Incretin therapies have emerged as key interventions for glycemic control and weight reduction, and are now among Canada's costliest outpatient drug classes. This review synthesizes current clinical and economic evidence on the cost-effecti...
Cerebral Edema and Brain Death Following Intravenous N-Acetylcysteine Overdose: A Case Report [0.03%]
静脉注射乙酰半胱氨酸过量致脑水肿和脑死亡的病例报告
Riley James Hartmann,Sunil Pradhan,Diana Bylyku et al.
Riley James Hartmann et al.
N-acetylcysteine (NAC) infusions are rarely associated with cerebral edema. We present a patient that received 1242.2 mg/kg intravenous NAC over 8.3 hours who developed seizures, cerebral edema, and died. A 17-24 year-old female (48.3 kg) p...
Editorial Expression of Concern: Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1 [0.03%]
撤稿声明：通过激活SIRT1使p53/微rna-34A低表达_metformin减弱心肌细胞缺血再灌注诱导的细胞凋亡研究存在数据造假行为
Weiwei Li,Sheng Jin,Jie Hao et al.
Weiwei Li et al.
Variability in Agitated Saline Echocardiography Protocols: A Cross-Sectional Analysis of Bubble Study Techniques in Echo Labs Across Alberta, Canada [0.03%]
关于阿省加拿大各超声心动图实验室中活动盐水心超检查方案变异性及气泡研究技术的横向分析
Logesh Selvakumar,Jonathan Choy,Roman Rashkovetsky et al.
Logesh Selvakumar et al.
Intrapulmonary right-to-left shunts (RLS) are a clinical concern in Hereditary Hemorrhagic Telangiectasia (HHT), contributing to dyspnea, brain abscess, and ischemic stroke. HHT is a genetic disorder characterized by arteriovenous malformat...
Potassium depolarized rat uterus in response to oxytocin and its structural analogues: Kinetic analysis [0.03%]
催产素及其结构类似物对钾去极化的大鼠子宫的作用：动力学分析
Vladimir Pliska,Denis Crankshaw
Vladimir Pliska
The subject of this communication is the kinetic analysis of dynamic processes in the myometrium of rats in a depolarized state, with a focus on their biomechanics and possible implications in obstetrics. Depolarization was achieved by incr...
Ameliorative effect of roxithromycin against prostate inflammation-induced chronic pelvic pain in a preclinical model [0.03%]
罗红霉素对前列腺炎小鼠模型慢性盆腔痛的改善作用研究
Vishnu Prabha P,Prasenjit Das,Sneha Vangaveti et al.
Vishnu Prabha P et al.
In view of the well-known anti-inflammatory property of roxithromycin, the present study was carried out to evaluate its efficacy in ameliorating prostate inflammation-induced chronic pelvic pain in rat model. Inflammation was induced by si...
Inhibition of ADAMTS1 and ATP citrate lyase attenuates connexin-43 degradation and HFrEF [0.03%]
抑制ADAMTS1和ATP柠檬酸裂解酶可减轻Cx43降解并缓解HFrEF病情发展
Yu-Ting Zheng,Suresh C Tyagi
Yu-Ting Zheng
Human genome- and transcriptome-wide analyses revealed that 56% of heart failure cases have unknown causes. Interestingly, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is one of those causes. Previously, we have s...
Correction: Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose [0.03%]
纠正：姜黄素二甲氧基衍生物-人血清白蛋白缀合物的药理安全性及其潜在治疗作用
Mejo C Korah,V S Harikrishnan,S Deepa et al.
Mejo C Korah et al.
Effect of ostarine on glucose level, lipid profile, and osteoporosis in streptozotocin induced diabetic male rats [0.03%]
Ostarine对链脲霉素诱导的雄性糖尿病大鼠血糖水平、脂质状况和骨质疏松的影响
Aml I Gadallah,Azza S Abdelhaffez,Ola A Hussein et al.
Aml I Gadallah et al.
This study aimed to evaluate ostarine effects on blood glucose, dyslipidemia, and osteoporosis in diabetic rats. Forty-eight adult male rats were divided into six groups (Control, Ostarine: 0.4 mg/kg daily orally, diabetes mellitus (DM), DO...
The Potential for Complex Interplay Between GLP-1 Receptor Agonists, Gut Microbiome, and Obesity Management [0.03%]
GLP-1受体激动剂、肠道菌群与肥胖管理之间的复杂相互作用的潜力
Abigail Johnson,Erin N O&#x;Sullivan,Peerada Valyasevi et al.
Abigail Johnson et al.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a class of medications used to treat and manage type 2 diabetes mellitus (T2DM) and obesity. The present narrative review explores potential interactions between the gut microbiome a...