Myocardial connexin-43 is upregulated in response to acute cardiac injury in rats [0.03%]
大鼠急性心脏损伤后心肌连接蛋白43的上调表达
Csilla Viczenczova,Branislav Kura,Kiranj K Chaudagar et al.
Csilla Viczenczova et al.
We aimed to explore whether myocardial intercellular channel protein connexin-43 (Cx43) along with PKCε and MMP-2 might be implicated in responses to acute cardiac injury induced by 2 distinct sublethal interventions in Wistar rats. Animal...
Functional β2-adrenoceptors in rat left atria: effect of foot-shock stress [0.03%]
急性应激对大鼠左心耳功能β2-肾上腺素受体的影响研究
André Luiz de Moura,Stephen Hyslop,Dora M Grassi-Kassisse et al.
André Luiz de Moura et al.
Altered sensitivity to the chronotropic effect of catecholamines and a reduction in the β1/β2-adrenoceptor ratio have previously been reported in right atria of stressed rats, human failing heart, and aging. In this report, we investigate...
Infliximab alleviates the mortality, mesenteric hypoperfusion, aortic dysfunction, and multiple organ damage in septic rats [0.03%]
英夫利昔单抗可缓解大鼠脓毒症的死亡率、肠系膜低灌注、主动脉功能障碍和多器官损伤
Erdem Kamil Ozer,Mustafa Tugrul Goktas,Ibrahim Kilinc et al.
Erdem Kamil Ozer et al.
Tumor necrosis factor-alpha (TNF-α) is a pivotal mediator that triggers inflammatory process, oxidative stress, and multiple organ injury in sepsis. We investigated the effects of infliximab on survival, mesenteric artery blood flow (MBF),...
Antioxidant tempol suppresses heart cytosolic phospholipase A2α stimulated by chronic intermittent hypoxia [0.03%]
抗氧化剂.tempol.抑制慢性间歇低氧刺激的心肌胞质磷脂酶A2α
Petra Míčová,Martina Klevstig,Kristýna Holzerová et al.
Petra Míčová et al.
Adaptation to chronic intermittent hypoxia (CIH) is associated with reactive oxygen species (ROS) generation implicated in the improved cardiac tolerance against acute ischemia-reperfusion injury. Phospholipases A2 (PLA2s) play an important...
Improved cardiovascular autonomic modulation in transgenic rats expressing an Ang-(1-7)-producing fusion protein [0.03%]
表达Ang-(1-7)产生融合蛋白的转基因大鼠的心血管自主神经调节改善
Daniela Ravizzoni Dartora,Maria-Claudia Irigoyen,Karina Rabello Casali et al.
Daniela Ravizzoni Dartora et al.
Angiotensin-(1-7) counterbalances angiotensin II cardiovascular effects. However, it has yet to be determined how cardiovascular autonomic modulation may be affected by chronic and acute elevation of Ang-(1-7). Hemodynamics and cardiovascul...
Development of a novel rationally designed antibiotic to inhibit a nontraditional bacterial target [0.03%]
一种针对非传统细菌靶点的新型理性设计抗生素的研发
Pavel Dibrov,Elena Dibrov,Thane G Maddaford et al.
Pavel Dibrov et al.
The search for new nontraditional targets is a high priority in antibiotic design today. Bacterial membrane energetics based on sodium ion circulation offers potential alternative targets. The present work identifies the Na+-translocating N...
Protective effects of tempol in an experimental ovarian ischemia-reperfusion injury model in female Wistar albino rats [0.03%]
tempol对卵巢缺血再灌注损伤的保护作用研究
Neslihan Pınar,Oya Soylu Karapınar,Oğuzhan Özcan et al.
Neslihan Pınar et al.
The aim of this study was to investigate the antioxidant effects of tempol on ovarian ischemia-reperfusion (I/R) injury in rats. Forty female Wistar albino rats were randomly divided into 5 groups: Group I, sham; Group II, ischemia (I); Gro...
Trimodal rescue of hind limb ischemia with growth factors, cells, and nanocarriers: fundamentals to clinical trials [0.03%]
生长因子、细胞和纳米载体的三重救援疗法改善下肢缺血：从基础到临床试验
Rajesh Lakshmanan,Gopi Ukani,Muhammad Tipu Rishi et al.
Rajesh Lakshmanan et al.
Peripheral artery disease is a severe medical condition commonly characterized by critical or acute limb ischemia. Gradual accumulation of thrombotic plaques in peripheral arteries of the lower limb may lead to intermittent claudication or ...
Protective effects of telmisartan and tempol on lipopolysaccharide-induced cognitive impairment, neuroinflammation, and amyloidogenesis: possible role of brain-derived neurotrophic factor [0.03%]
氯沙坦和四氢精氨酸对脂多糖诱导的認知障礙、神經炎症和淀粉样蛋白生成的保护作用：脑源性神经生长因子的可能作用
Waleed A I Khallaf,Basim A S Messiha,Amira M H Abo-Youssef et al.
Waleed A I Khallaf et al.
Angiotensin II has pro-inflammatory and pro-oxidant potentials. We investigated the possible protective effects of the Angiotensin II receptor blocker telmisartan, compared with the superoxide scavenger tempol, on lipopolysaccharide (LPS)-i...
Downregulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines [0.03%]
3-甲基胆烷烯诱导人肝癌细胞系中CYP2C8表达下调
Rucha Utgikar,David S Riddick
Rucha Utgikar
The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. The molecular mechanisms, functional conseq...