Resveratrol promotes recovery of immune function of immunosuppressive mice by activating JNK/NF-κB pathway in splenic lymphocytes [0.03%]
白藜芦醇通过激活脾淋巴细胞的JNK/NF-κB信号通路促进免疫抑制小鼠免疫功能恢复
Xin Lai,Mei Cao,Xu Song et al.
Xin Lai et al.
Resveratrol, a natural compound found in over 70 plants, is known to possess immunoregulatory effects and anti-inflammatory activity. It has been shown that resveratrol has regulatory effects on different signaling pathways in different dis...
HDAC2 is required by the physiological concentration of glucocorticoid to inhibit inflammation in cardiac fibroblasts [0.03%]
生理浓度糖皮质激素抑制心脏纤维母细胞炎症依赖组蛋白脱乙酰基酶2
Haining Zhang,Yanhua He,Guiping Zhang et al.
Haining Zhang et al.
We previously suggested that endogenous glucocorticoids (GCs) may inhibit myocardial inflammation induced by lipopolysaccharide (LPS) in vivo. However, the possible cellular and molecular mechanisms were poorly understood. In this study, we...
Treatment of the cardiac hypertrophic response and heart failure with ginseng, ginsenosides, and ginseng-related products [0.03%]
人参、皂苷及其相关产品对心脏肥大反应和心力衰竭的治疗作用
Morris Karmazyn,Xiaohong Tracey Gan
Morris Karmazyn
Heart failure is a major medical and economic burden throughout the world. Although various treatment options are available to treat heart failure, death rates in both men and women remain high. Potential adjunctive therapies may lie with u...
Vascular function and arginine and dimethylarginines in gentamicin-induced renal failure: a possible effect of heme oxygenase 1 inducer hemin [0.03%]
血管功能和精氨酸及二甲基精氨酸在庆大霉素引起的肾衰竭中的作用：血红素加氧酶1诱导剂 hin 的可能效果
Esra Aycan-Ustyol,Merve Kabasakal,Seldag Bekpinar et al.
Esra Aycan-Ustyol et al.
Increased oxidative stress and disturbance in nitric oxide bioavailability lead to endothelial dysfunction and cardiovascular complication in renal disease. Gentamicin (GM), a commonly used antibiotic, exhibits a toxic effect on renal proxi...
Evidence of necroptosis in hearts subjected to various forms of ischemic insults [0.03%]
缺血损伤心肌中坏死性凋亡的证据
Adriana Adameova,Jaroslav Hrdlicka,Adrian Szobi et al.
Adriana Adameova et al.
Long-lasting ischemia can result in cell loss; however, repeated episodes of brief ischemia increase the resistance of the heart against deleterious effects of subsequent prolonged ischemic insult and promote cell survival. Traditionally, i...
Rohini Baradan,John M Hollander,Samarjit Das
Rohini Baradan
Over the last 2 decades, mi(cro)RNAs have emerged as one of the key regulators of metabolic homeostasis. Most of the studies have highlighted that, in the cytoplasm, miRNAs directly bind to the 3'-UTR (untranslated region) of a mRNA. Conven...
The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans [0.03%]
新型氨茶碱与溴莫尼定联合治疗人体低氧血症的方法
Trond-Eirik Strand,Hasse Z Khiabani,Alina Boico et al.
Trond-Eirik Strand et al.
Hypoxemia can be life-threatening, both acutely and chronically. Because hypoxemia causes vascular dysregulation that further restricts oxygen availability to tissue, it can be pharmacologically addressed. We hypothesized that theophylline ...
Randomized Controlled Trial
Canadian journal of physiology and pharmacology. 2017 Sep;95(9):1009-1018. DOI:10.1139/cjpp-2016-0635 2017
Alice E Kane,Omar Ayaz,Anjali Ghimire et al.
Alice E Kane et al.
Frailty is considered a state of high vulnerability for adverse health outcomes for people of the same age. Those who are frail have higher mortality, worse health outcomes, and use more health care services than those who are not frail. De...
cAMP attenuates angiotensin-II-induced Egr-1 expression via PKA-dependent signaling pathway in vascular smooth muscle cells [0.03%]
cAMP通过PKA依赖性信号途径削弱血管平滑肌细胞中血管紧张素II诱导的Egr-1表达作用
Estelle R Simo-Cheyou,Viktoria Youreva,Ashok K Srivastava
Estelle R Simo-Cheyou
cAMP has been shown to inhibit vascular smooth muscle cell proliferation and exerts a vasculoprotective effect. An upregulation of the early growth response protein-1 (Egr-1) expression has been linked with the development of atherosclerosi...
Victoria Sid,Yaw L Siow,Karmin O
Victoria Sid
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver conditions that are characterized by steatosis, inflammation, fibrosis, and liver injury. The global prevalence of NAFLD is rapidly increasing in proportion to the risi...