Beneficial effects of rosmarinic acid against alcohol-induced hepatotoxicity in rats [0.03%]
鼠李素对酒精性肝损伤大鼠的保护作用
Parisa Hasanein,Rosa Seifi
Parisa Hasanein
Alcohol is a severe hepatotoxicant that causes a variety of liver disorders. Rosmarinic acid (RA), a natural phenol, shows some biological activities, including antioxidant and anti-inflammatory effects. We investigated the effects of RA (1...
Chelating effects of carnosine in ameliorating nickel-induced nephrotoxicity in rats [0.03%]
卡尼丁改善镍致大鼠肾毒性的螯合作用研究
Parisa Hasanein,Zhila Felegari
Parisa Hasanein
The kidney is one of the main organs affected by nickel toxicity. We investigated the protective effects of carnosine on nickel-induced oxidative stress in kidney of rats. Animals received NiSO4 (20 mg·kg-1·day-1 intragastrically) and (or...
Olprinone protects the liver from ischemia-reperfusion injury through oxidative stress prevention and protein kinase Akt activation [0.03%]
奥普利酮通过抗氧化应激和活化蛋白激酶Akt预防肝缺血再灌注损伤
Mohamed Bejaoui,Mohamed Amine Zaouali,Rim Sakly et al.
Mohamed Bejaoui et al.
Liver ischemia-reperfusion (IR) injury is inevitable in surgical procedures such as hepatic resection and liver transplantation. It represents a leading cause of liver graft dysfunction and primary nonfunction after transplantation. Phospho...
Alcohol extract of North American ginseng (Panax quinquefolius) reduces fatty liver, dyslipidemia, and other complications of metabolic syndrome in a mouse model [0.03%]
北美人参(Panax quinquefolius)的醇提物可减轻代谢综合征小鼠模型中的脂肪肝、脂代谢紊乱及其他并发症
Ratnesh K Singh,Edmund Lui,David Wright et al.
Ratnesh K Singh et al.
We investigated whether North American ginseng (Panax quinquefolius) could reduce development of the metabolic syndrome phenotype in a mouse model (ETKO) of the disease. Young ETKO mice have no disease but similar to humans start to develop...
Sodium tanshinone IIA sulfonate prevents lipopolysaccharide-induced inflammation via suppressing nuclear factor-κB signaling pathway in human umbilical vein endothelial cells [0.03%]
丹参素钠通过抑制核因子-κB信号途径预防脂多糖诱导的内皮细胞炎症反应
Jun Cheng,Tangting Chen,Pengyun Li et al.
Jun Cheng et al.
Sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA, has been demonstrated to have potent anti-inflammatory properties. However, the protective effects of STS on lipopolysaccharide (LPS)-induced inflammation ...
Effect of tolbutamide on tetraethylammonium-induced postsynaptic zinc signals at hippocampal mossy fiber-CA3 synapses [0.03%]
(tolbutamide对四乙胺诱导的海马苔藓纤维-CA3突触postsynaptic锌信号的影响)
Fatima C Bastos,Vanessa N Corceiro,Sandra A Lopes et al.
Fatima C Bastos et al.
The application of tetraethylammonium (TEA), a blocker of voltage-dependent potassium channels, can induce long-term potentiation (LTP) in the synaptic systems CA3-CA1 and mossy fiber-CA3 pyramidal cells of the hippocampus. In the mossy fib...
Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain-pituitary-gonadal axis in male rats [0.03%]
牛磺酸逆转雄性大鼠脑垂体生殖轴中氟化钠介导的炎症、caspase-3活性和氧化损伤增加的作用
Isaac A Adedara,Bolanle F Olabiyi,TeminiJesu D Ojuade et al.
Isaac A Adedara et al.
Excessive exposure to fluoride is associated with male reproductive dysfunction in humans and animals. Taurine (2-aminoethane sulfonic acid) is a free intracellular β-amino acid with antioxidant, anti-inflammatory, and neuroprotective prop...
Michael Belanger,Luke Tan,Carin Wittnich
Michael Belanger
Despite significant advances in the management and treatment of heart disease in children, there continue to be patients who have worse outcomes than might be expected. A number of risk factors that could be responsible have been identified...
Carotid versus coronary atherosclerosis burdens in acute compared with chronic symptomatic coronary artery disease [0.03%]
急性与慢性冠心病患者的颈动脉与冠状动脉粥样硬化病变负担比较
Stéphanie LeBlanc,Karine Bibeau,Olivier F Bertrand et al.
Stéphanie LeBlanc et al.
Prediction of coronary events remains elusive. Carotid atherosclerosis may be a surrogate for coronary risk, as carotid and coronary diseases occur simultaneously - albeit at times with a weak association - depending on clinical presentatio...