Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages [0.03%]
advanced glycation end products通过影响巨噬细胞上的ABCA1表达来影响胆固醇稳态
Olivier Kamtchueng Simo,Souade Ikhlef,Hicham Berrougui et al.
Olivier Kamtchueng Simo et al.
Reverse cholesterol transport (RCT), which is intimately linked to high-density lipoproteins (HDLs), plays a key role in cholesterol homeostasis and the prevention of atherosclerosis. The goal of the present study was to investigate the eff...
Resveratrol prevents angiotensin II-induced hypertrophy of vascular smooth muscle cells through the transactivation of growth factor receptors [0.03%]
白藜芦醇通过生长因子受体的转激活作用预防血管平滑肌细胞肥大
Ekhtear Hossain,Madhu B Anand-Srivastava
Ekhtear Hossain
We previously showed that augmented levels of endogenous angiotensin II (AngII) contribute to vascular smooth muscle cell (VSMC) hypertrophy through the transactivation of growth factor receptors in spontaneously hypertensive rats. Resverat...
Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice [0.03%]
载脂蛋白E基因敲除鼠血小板聚集的抑制受到抑制
É Carrier,M Houde,M Grandbois et al.
É Carrier et al.
In the present study, we assessed whether the endogenous platelet inhibitory mechanisms are altered in the early to moderate stages of the atherosclerotic process. Apolipoprotein E deficient mice (ApoE-/-), a mouse model of atherosclerosis,...
Carbon dioxide water-bath treatment augments peripheral blood flow through the development of angiogenesis [0.03%]
二氧化碳水浴治疗通过促进血管生成来增加外周血流量
Yan-Jun Xu,Vijayan Elimban,Naranjan S Dhalla
Yan-Jun Xu
In this study, we investigated the effects of CO2 water-bath therapy on blood flow and angiogenesis in the ischemic hind limb, as well as some plasma angiogenic factors in peripheral ischemic model. The hind limb ischemia was induced by occ...
Antioxidant compound (E)-2-benzylidene-4-phenyl-1,3-diselenole protects rats against thioacetamide-induced acute hepatotoxicity [0.03%]
(E)-2-苯基亚烯胺基-4-硒代戊二烯-1,3-二硒化合物对噻唑烷酮所致大鼠急性肝损伤的保护作用
Angélica S Reis,Mikaela P Pinz,Cristiani F Bortolatto et al.
Angélica S Reis et al.
The aim of this study was to investigate whether (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD) protects against hepatotoxicity induced by thioacetamide (TAA). On the first day of treatment, male adult Wistar rats received BPD (10 or 50 mg...
Transcriptional regulation of endothelial-to-mesenchymal transition in cardiac fibrosis: role of myocardin-related transcription factor A and activating transcription factor 3 [0.03%]
心脏纤维化中内皮-间充质转化的转录调控：肌球蛋白相关转录因子A和活化转录因子3的作用
Vibhuti Sharma,Nilambra Dogra,Uma Nahar Saikia et al.
Vibhuti Sharma et al.
The etiology of cardiac fibrogenesis is quite diverse, but a common feature is the presence of activated fibroblasts. Experimental evidence suggests that a subset of cardiac fibroblasts is derived via transition of vascular endothelial cell...
Noninvasive approach to mend the broken heart: Is "remote conditioning" a promising strategy for application in humans? [0.03%]
非侵入性治疗受损心脏的方案：“远程调理”在人类应用中的前景如何？
Táňa Ravingerová,Veronika Farkašová,Lucia Griecsová et al.
Táňa Ravingerová et al.
Currently, there are no satisfactory interventions to protect the heart against the detrimental effects of ischemia-reperfusion injury. Although ischemic preconditioning (PC) is the most powerful form of intrinsic cardioprotection, its appl...
Changes in mitochondrial properties may contribute to enhanced resistance to ischemia-reperfusion injury in the diabetic rat heart [0.03%]
线粒体性质的改变可能会增加糖尿病大鼠心脏对缺血-再灌注损伤的抵抗能力
Martina Muráriková,Miroslav Ferko,Iveta Waczulíková et al.
Martina Muráriková et al.
Diabetes mellitus, besides having deleterious effects, induces cardiac adaptation that may reduce the heart's susceptibility to ischemia-reperfusion (IR) injury. This study aimed to investigate whether changes in mitochondrial properties ar...
Implication of microRNAs in the development and potential treatment of radiation-induced heart disease [0.03%]
微小核糖核酸在放射性心脏病发生和发展中的潜在作用及治疗意义研究进展
Branislav Kura,Pavel Babal,Jan Slezak
Branislav Kura
Radiotherapy is the most commonly used methodology to treat oncological disease, one of the most widespread causes of death worldwide. Oncological patients cured by radiotherapy applied to the mediastinal area have been shown to suffer from...
Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice [0.03%]
儿茶素EGCG通过调节CREB/BDNF/TrkB和PI3K/Akt/mTOR信号途径对抗异氟醚诱导的新生鼠神经元凋亡的作用机制研究
Mei-Li Ding,Hui Ma,Yi-Gang Man et al.
Mei-Li Ding et al.
Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, is an effective antioxidant and possesses neuroprotective effects. Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucial for...