Neuropeptide Y and its receptors in ventricular endocardial endothelial cells [0.03%]
神经肽Y及其受体在心室内膜内皮细胞中的表达
Danielle Jacques,Pedro D&#x;Orléans-Juste,Sheldon Magder et al.
Danielle Jacques et al.
Endocardial endothelial cells (EECs) constitute an important component of the heart. These cells form a monolayer that covers the cavities of the right (EECRs) and left (EECLs) ventricles. They play an important role in cardiac excitation-c...
Atrial-selective K+ channel blockers: potential antiarrhythmic drugs in atrial fibrillation? [0.03%]
选择性作用于心房的钾通道阻滞剂：心房颤动的潜在抗心律失常药物？
Ursula Ravens
Ursula Ravens
In the wake of demographic change in Western countries, atrial fibrillation has reached an epidemiological scale, yet current strategies for drug treatment of the arrhythmia lack sufficient efficacy and safety. In search of novel medication...
Role of endothelin-1 and its receptors, ETA and ETB, in the survival of human vascular endothelial cells [0.03%]
内皮素-1及其受体ETA和ETB在人血管内皮细胞存活中的作用
Marianne Mikhail,Pierre H Vachon,Pedro D&#x;Orléans-Juste et al.
Marianne Mikhail et al.
Our previous work showed the presence of endothelin-1 (ET-1) receptors, ETA and ETB, in human vascular endothelial cells (hVECs). In this study, we wanted to verify whether ET-1 plays a role in the survival of hVECs via the activation of it...
Angiotensin II receptors' modulation of calcium homeostasis in human vascular endothelial cells [0.03%]
血管内皮细胞中血管紧张素Ⅱ受体对钙稳态的调节作用
Maud Kamal,Danielle Jacques,Ghassan Bkaily
Maud Kamal
Angiotensin II (AngII) plays an important role in the regulation of vascular smooth muscle function. However, little is known about AngII and its receptors AT1 (AT1R) and AT2 (AT2R) and their modulation of intracellular calcium in vascular ...
Difference in the response to angiotensin II between left and right ventricular endocardial endothelial cells [0.03%]
左、右心室内皮细胞(ang Ⅱ)的区别响应胰岛素样生长因子-1
Danielle Jacques,Nelly Abdel-Karim Abdel-Malak,Nadia Abou Abdallah et al.
Danielle Jacques et al.
Previous studies focused on the right ventricular endocardial endothelial cells (EECRs) and showed that angiotensin II (Ang II) induced increase in cytosolic and nuclear calcium via AT1 receptor activation. In the present study, we verified...
Na+-H+ exchanger and proton channel in heart failure associated with Becker and Duchenne muscular dystrophies [0.03%]
贝克尔型及杜氏肌营养不良相关心力衰竭的钠-氢交换体和质子通道功能异常
Ghassan Bkaily,Danielle Jacques
Ghassan Bkaily
Cardiomyopathy is found in patients with Duchenne (DMD) and Becker (BMD) muscular dystrophies, which are linked muscle diseases caused by mutations in the dystrophin gene. Dystrophin defects are not limited to DMD but are also present in mi...
Vascular senescence and ageing: a role for the MEOX proteins in promoting endothelial dysfunction [0.03%]
血管衰老与衰老：MEOX蛋白在促进内皮功能障碍中的作用
Josette M Northcott,Michael P Czubryt,Jeffrey T Wigle
Josette M Northcott
In the vascular system, ageing is accompanied by the accrual of senescent cells and is associated with an increased risk of vascular disease. Endothelial cell (EC) dysfunction is a hallmark of vascular disease and is characterized by decrea...
Effect of lysophosphatidylglycerol on intracellular free Ca2+ concentration in A10 vascular smooth muscle cells [0.03%]
溶血磷脂甘油酯对A10血管平滑肌细胞内游离钙浓度的影响
Ying Zhang,Jing-Dian Zhang,Ming-Qin Zhu et al.
Ying Zhang et al.
Although plasma levels of lysophosphatidylglycerol (LPG) are increased in hypertension, its role in the pathogenesis of vascular defects is not clear. In view of the importance of Ca2+ overload in causing vascular smooth muscle (VSM) dysfun...
New insights into the non-hemostatic role of von Willebrand factor in endothelial protection [0.03%]
血管性血友病因子在内皮保护中的非止血作用的新见解
Silvia Agostini,Vincenzo Lionetti
Silvia Agostini
During exposure to ischemia-reperfusion (I/R) insult, angiotensin II (AngII)-induced endothelin-1 (ET-1) upregulation in endothelial cells progressively impairs nitric oxide (NO) bioavailability while increasing levels of superoxide anion (...
Specific plasma oxylipins increase the odds of cardiovascular and cerebrovascular events in patients with peripheral artery disease [0.03%]
特定血浆氧脂类可增加外周动脉疾病患者发生心血管和脑血管事件的风险
Stephanie P B Caligiuri,Harold M Aukema,Amir Ravandi et al.
Stephanie P B Caligiuri et al.
Oxylipins and fatty acids may be novel therapeutic targets for cardiovascular disease. The objective was to determine if plasma oxylipins or fatty acids can influence the odds of cardiovascular/cerebrovascular events. In 98 patients (25 fem...
Randomized Controlled Trial
Canadian journal of physiology and pharmacology. 2017 Aug;95(8):961-968. DOI:10.1139/cjpp-2016-0615 2017