Potential markers and metabolic processes involved in the mechanism of radiation-induced heart injury [0.03%]
与放射诱发心脏损伤机制有关的潜在标志物和代谢过程
Jan Slezak,Branislav Kura,Pavel Babal et al.
Jan Slezak et al.
Irradiation of normal tissues leads to acute increase in reactive oxygen/nitrogen species that serve as intra- and inter-cellular signaling to alter cell and tissue function. In the case of chest irradiation, it can affect the heart, blood ...
The role of damage- and pathogen-associated molecular patterns in inflammation-mediated vulnerability of atherosclerotic plaques [0.03%]
损伤和病原体相关分子模式在动脉粥样硬化斑块炎症介导的易损性中的作用
Vikrant Rai,Devendra K Agrawal
Vikrant Rai
Atherosclerosis is a chronic inflammatory disease resulting in the formation of the atherosclerotic plaque. Plaque formation starts with the inflammation in fatty streaks and progresses through atheroma, atheromatous plaque, and fibroathero...
The role of paraoxonase 1 in regulating high-density lipoprotein functionality during aging [0.03%]
生命衰老过程中卵磷脂胆固醇酰基转移酶通过调节高密度脂蛋白功能参与动脉粥样硬化发展的机制研究
Abdelouahed Khalil,Olivier Kamtchueng Simo,Souade Ikhlef et al.
Abdelouahed Khalil et al.
Pharmacological interventions to increase the concentration of high-density lipoprotein (HDL) have led to disappointing results and have contributed to the emergence of the concept of HDL functionality. The anti-atherogenic activity of HDLs...
Expression of classical mediators in hearts of rats with hepatic dysfunction [0.03%]
肝功能不全大鼠心脏组织经典介质的表达
Dagmar Jarkovska,Monika Bludovska,Eliska Mistrova et al.
Dagmar Jarkovska et al.
Liver cirrhosis is associated with impairment of cardiovascular function including alterations of the heart innervation, humoral and nervous dysregulation, changes in systemic circulation and electrophysiological abnormalities. Choline acet...
The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats [0.03%]
不同剂量螺内酯对链脲佐菌素诱导的糖尿病大鼠心脏功能急性影响
Aleksandra Vranic,Stefan Simovic,Petar Ristic et al.
Aleksandra Vranic et al.
Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. A recent study showed that patients with diabetes mellitus treated with mineraloco...
Beat-to-beat variability of cardiac action potential duration: underlying mechanism and clinical implications [0.03%]
心肌动作电位持续时间搏动变异性的机制及临床意义
Péter P Nánási,János Magyar,András Varró et al.
Péter P Nánási et al.
Beat-to-beat variability of cardiac action potential duration (short-term variability, SV) is a common feature of various cardiac preparations, including the human heart. Although it is believed to be one of the best arrhythmia predictors, ...
Zsófia Mezei,Sándor Váczi,Viktória Török et al.
Zsófia Mezei et al.
Hyperglycemia, hyperlipidemia, and free radicals result in platelet activation and atherogenesis. Kisspeptin (KP) is able to regulate metabolism, hemostasis, and the development of atherosclerosis. We examined whether platelet aggregation o...
Methylene blue improves mitochondrial respiration and decreases oxidative stress in a substrate-dependent manner in diabetic rat hearts [0.03%]
美蓝通过底物依赖的方式改善糖尿病大鼠心脏线粒体呼吸并降低氧化应激水平
Oana M Duicu,Andreea Privistirescu,Adrian Wolf et al.
Oana M Duicu et al.
Diabetic cardiomyopathy has been systematically associated with compromised mitochondrial energetics and increased generation of reactive oxygen species (ROS) that underlie its progression to heart failure. Methylene blue is a redox drug wi...
Ablation of toll-like receptor 4 mitigates cardiac mitochondrial dysfunction in hyperhomocysteinemia [0.03%]
toll-like受体4敲除缓解高同型半胱氨酸血症中心肌线粒体功能障碍
Nevena Jeremic,Gregory J Weber,Suresh C Tyagi
Nevena Jeremic
Hyperhomocysteinemia (HHcy) is a risk factor for adverse cardiovascular events; however, the mechanism for development of this disease is still unknown. Toll-like receptor 4 (TRL4) is a molecule involved in the immune response pathway and i...
Risk stratification in patients with heart failure: the value of considering both global longitudinal left ventricular strain and mechanical dispersion [0.03%]
心力衰竭患者的风险分层：同时考虑整体纵向左室应变和机械离散值的价值
Cristian Mornoş,Danina Muntean,Aniko Mornoş et al.
Cristian Mornoş et al.
In previous studies, mechanical dispersion (MD) predicted ventricular arrhythmias independently of left ventricular ejection fraction (LVEF). Moreover, the combination of MD and global longitudinal strain (GLS) increased the prediction of a...