Limb remote ischemia per-conditioning protects the heart against ischemia-reperfusion injury through the opioid system in rats [0.03%]
缺血再灌注损伤条件下远端肢体预处理通过阿片受体系统保护心肌的作用及机制研究
Li Zhang,Hui Guo,Fang Yuan et al.
Li Zhang et al.
Remote ischemia per-conditioning (RPerC) has been demonstrated to have cardiac protection, but the underlying mechanism remains unclear. This study aimed to investigate the mechanism underlying cardiac protection of RPerC. Adult male Spragu...
Virtual Morris task responses in individuals in an abstinence phase from alcohol [0.03%]
戒酒期间个体的虚拟莫里斯任务反应
Mauro Ceccanti,Giovanna Coriale,Derek A Hamilton et al.
Mauro Ceccanti et al.
The present study was aimed at examining spatial learning and memory, in 33 men and 12 women with alcohol use disorder (AUD) undergoing ethanol detoxification, by using a virtual Morris task. As controls, we recruited 29 men and 10 women am...
Age-related testosterone declines can be detected in men's fingernails [0.03%]
男性指尖的指甲可以检测出与年龄相关的睾丸激素下降
Devorah Matas,Lee Koren
Devorah Matas
Testosterone plays multiple roles in the regulation of development, physiology, reproduction, and behavior. Age-related testosterone declines are expected in the population. However, measuring circulating testosterone is especially challeng...
Protective effect of rimonabant, a canabinoid receptor 1 antagonist, on nonalcoholic fatty liver disease in a rat model through modulation of the hepatic expression of activin A and follistatin [0.03%]
利莫那班通过调节肝脏中Activin A和Follistatin的表达对抗非酒精性脂肪肝病的保护作用研究
Noha I Hussien,Hanan I El-Kerdasy,Mohammad El-Tantawy Ibrahim
Noha I Hussien
Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver morbidity and mortality, and there is still no proven effective therapy. The endocannabinoid system plays an important role in various liver diseases. Activin A is a member...
Antibiotic drug piperacillin induces neuron cell death through mitochondrial dysfunction and oxidative damage [0.03%]
碳青霉烯类抗生素帕尼培南通过线粒体功能障碍和氧化损伤诱导神经元细胞死亡
Shan Jiang,Tong Li,Xiao Zhou et al.
Shan Jiang et al.
Although nerve damage/toxicity has been shown to be one of the side effects in patients given prolonged antibiotic treatment, the mechanisms of the action of antibiotics on neuron cells are not clear. In this work, we investigated the toxic...
The beneficial effects of resveratrol on steatosis and mitochondrial oxidative stress in HepG2 cells [0.03%]
白藜醇改善HepG2細胞脂肪變性和线粒体氧化应激的效应
Magdalena Izdebska,Iwona Piątkowska-Chmiel,Agnieszka Korolczuk et al.
Magdalena Izdebska et al.
Nonalcoholic fatty liver disease (NAFLD) is currently one of the most common chronic liver diseases, especially in developed countries. One group of substances with a potential use in the treatment of NAFLD are plant polyphenols, represente...
Calpain inhibitor I attenuates atherosclerosis and inflammation in atherosclerotic rats through eNOS/NO/NF-κB pathway [0.03%]
钙蛋白酶抑制剂I通过eNOS/NO/NF-κB信号通路减轻动脉粥样硬化炎症作用研究
Lan Yu,Meihui Yin,Xueyan Yang et al.
Lan Yu et al.
We previously reported that calpain, the Ca2+-sensitive cysteine protease, gets involved in atherogenesis. This study aimed to investigate the effects of calpain inhibitor I (CAI, 5 mg/kg per day) with or without NG-nitro-l-arginine-methyl ...
Modulation of N-methyl-d-aspartate receptors in isolated rat heart [0.03%]
大鼠分离心脏中N-甲基-D-天门冬酸受体的调节作用
Ivan Srejovic,Vladimir Zivkovic,Tamara Nikolic et al.
Ivan Srejovic et al.
Considering the limited data on the role of NMDA-Rs in the cardiovascular system, the aim of the present study was to examine the effects of NMDA and DL-Hcy TLHC, alone and in combination with glycine, memantine, and ifenprodil, in the isol...
Onset of decreased heart work is correlated with increased heart rate and shortened QT interval in high-carbohydrate fed overweight rats [0.03%]
高碳水化合物喂养的肥胖大鼠心肌做功下降相关的心率和QT间期变化
Aysegul Durak,Yusuf Olgar,Erkan Tuncay et al.
Aysegul Durak et al.
Mechanical activity of the heart is adversely affected in metabolic syndrome (MetS) characterized by increased body mass and marked insulin resistance. Herein, we examined the effects of high carbohydrate intake on cardiac function abnormal...
Contribution of monoamine oxidases to vascular oxidative stress in patients with end-stage renal disease requiring hemodialysis [0.03%]
终末期肾病血液透析患者单胺氧化酶对血管氧化应激的贡献
Diana Uțu,Stelian Pantea,Oana M Duicu et al.
Diana Uțu et al.
Arteriovenous fistula (AVF) is the "lifeline" for patients with end-stage renal disease (ESRD) undergoing hemodialysis. AVF maturation failure is a poorly understood process, one of the contributors being endothelial dysfunction due to oxid...