A 13-week low glycemic load diet and lifestyle modification program combining low glycemic load protein shakes and targeted nutraceuticals improved weight loss and cardio-metabolic risk factors [0.03%]
为期13周的低碳水化合物负荷饮食和生活方式干预结合使用蛋白奶昔和特定制剂改善了体重减轻和心血管代谢危险因素
Clinton J Dahlberg,Joseph J Ou,John G Babish et al.
Clinton J Dahlberg et al.
An open-label, randomized, exploratory study of 44 healthy overweight subjects with cardio-metabolic syndrome (CMS) risk factors was conducted to assess the safety, tolerability, and efficacy of a proprietary lifestyle modification program ...
Randomized Controlled Trial
Canadian journal of physiology and pharmacology. 2017 Dec;95(12):1414-1425. DOI:10.1139/cjpp-2016-0704 2017
Differential inhibition of rat and mouse microsome heme oxygenase by derivatives of imidazole and benzimidazole [0.03%]
咪唑和苯并咪唑的衍生物对大鼠和小鼠肝微粒体血红素氧合酶的不同抑制作用
Maaike Hum,Brian E McLaughlin,Xianqi Kong et al.
Maaike Hum et al.
Metalloporphyrin heme oxygenase (HO) inhibitors have made an important contribution to elucidating the role of HO in physiological processes. Nevertheless, their off-target effects have drawn substantial criticism, which prompted us to deve...
Glycosylation with O-linked β-N-acetylglucosamine induces vascular dysfunction via production of superoxide anion/reactive oxygen species [0.03%]
O-连接β-N-乙酰氨基葡萄糖残基糖基化通过超氧阴离子/反应性氧化物生成诱导血管功能障碍
Leonardo Souza-Silva,Rheure Alves-Lopes,Jéssica Silva Miguez et al.
Leonardo Souza-Silva et al.
Overproduction of superoxide anion (•O2-) and O-linked β-N-acetylglucosamine (O-GlcNAc) modification in the vascular system are contributors to endothelial dysfunction. This study tested the hypothesis that increased levels of O-GlcNAc-mo...
Protective effects of pioglitazone on vascular endothelial cell dysfunction induced by high glucose via inhibition of IKKα/β-NFκB signaling mediated by PPARγ in vitro [0.03%]
吡格列酮通过PPARγ介导的IKKα/β-NFκB信号抑制在体外对高糖诱导血管内皮细胞功能障碍的保护作用
Chunxiang Chen,Shaorong Peng,Fanghui Chen et al.
Chunxiang Chen et al.
PIO, a synthetic ligand for PPARγ, is used clinically to treat T2DM. However, little is known about its protective effects on endothelium and the underlying mechanisms. In this study, we sought to investigate the protective effects of PIO ...
Respiratory muscle training decreases diaphragm DNA damage in rats with heart failure [0.03%]
膈肌训练减少心力衰竭大鼠膈肌DNA损伤
Rodrigo B Jaenisch,Giuseppe P Stefani,Camila Durante et al.
Rodrigo B Jaenisch et al.
Respiratory muscle training (RMT) promotes beneficial effects on respiratory mechanics, heart and lung morphological changes, and hemodynamic variables in rats with heart failure (HF). However, the relation between RMT effects and diaphragm...
Local antinociceptive action of fluoxetine in the rat formalin assay: role of l-arginine/nitric oxide/cGMP/KATP channel pathway [0.03%]
氟西汀在大鼠甲醛试验中的局部抗痛觉作用：L-精氨酸/一氧化氮/cGMP/KATP通道通路的作用
Behnam Ghorbanzadeh,Mohammad Taghi Mansouri,Bahareh Naghizadeh et al.
Behnam Ghorbanzadeh et al.
The present study was conducted to evaluate the local antinociceptive actions of fluoxetine, a selective serotonin reuptake inhibitor, and the possible involvement of the l-arginine/NO/cGMP/KATP channel pathway in this effect using the form...
Resveratrol improves high-fat diet induced fatty liver and insulin resistance by concomitantly inhibiting proteolytic cleavage of sterol regulatory element-binding proteins, free fatty acid oxidation, and intestinal triglyceride absorption [0.03%]
白藜芦醇通过同时抑制SREBP切割、脂肪酸氧化以及肠道甘油三酯吸收改善高脂饮食引起的脂肪肝和胰岛素抵抗效应
Eman F Khaleel,Ghada A Abdel-Aleem,Dalia G Mostafa
Eman F Khaleel
Resveratrol (RES) has the ability to ameliorate nonalcoholic fatty liver disease (NAFLD) and the mechanism remains unclear. Hence, using high-fat diet (HFD) obese rat model, we investigated the effect of a low dose of RES (20 mg/kg) on the ...
NMDA receptors in the dorsal hippocampal area are involved in tramadol state-dependent memory of passive avoidance learning in mice [0.03%]
氯胺酮状态依赖记忆形成的海马N-甲基-D天冬氨酸受体的作用研究
Majid Jafari-Sabet,Hamed Mofidi,Mohammad-Sadegh Attarian-Khosroshahi
Majid Jafari-Sabet
The precise neurobiological mechanisms of tramadol abuse underlying the cognitive function are still unknown. The aim of the present study was to examine the possible effects of intra-CA1 injections of N-methyl-d-aspartate (NMDA), a glutama...
Effect of zoledronate, a third-generation bisphosphonate, on proliferation and apoptosis of human dental pulp stem cells [0.03%]
第三代双膦酸盐扎来ド龙对人牙髓干细胞增殖和凋亡的影响
Solmaz Pourgonabadi,Seyed Hadi Mousavi,Zahra Tayarani-Najaran et al.
Solmaz Pourgonabadi et al.
Clinical use of zoledronate is accompanied by osteonecrosis of the jaw but the pathogenesis is not well understood. We assumed that zoledronate may have cytotoxicity against stem cells of the oral cavity and in this way helps to initiate or...
Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through the SIRT1-mediated signaling pathway [0.03%]
羟基酪醇通过SIRT1介导的信号通路调节血管外膜成纤维细胞自噬
Weirong Wang,Ting Jing,Xiaofeng Yang et al.
Weirong Wang et al.
Hydroxytyrosol (HT), a phenolic compound in olive oil, exerts an anti-inflammatory effect in cardiovascular diseases. Recent studies found that autophagy was a therapeutic target of diseases. However, the effect of HT on autophagy in vascul...