Inna Rabinovich-Nikitin,Shuangbo Liu,Lorrie Kirshenbaum
Inna Rabinovich-Nikitin
Despite major advances in cardiac research over the past three decades, cardiovascular disease (CVD) still remains the leading cause of morbidity and mortality in women and men worldwide. However, a major challenge for health care providers...
Chloramphenicol alleviates 5-fluorouracil-induced cellular senescence through activation of autophagy [0.03%]
氯霉素通过激活自噬缓解氟尿嘧啶诱导的细胞衰老
Shi-Rui Bai,Qi Zhao,Hui-Jie Jia et al.
Shi-Rui Bai et al.
5-Fluorouracil (5-FU) is a first-line treatment for colorectal cancer, but side effects such as severe diarrhea are common in clinical use and have been linked to its induction of normal cell senescence. Chloramphenicol (CAP) is an antibiot...
Cardiovascular and physiological risk factors in women at mid-life and beyond [0.03%]
中年及中年后女性的心血管和生理学风险因素
Yenny A Rodriguez de Morales,Beth L Abramson
Yenny A Rodriguez de Morales
Cardiovascular disease (CVD) is the leading cause of death in women. After menopause, sex-specific and gender-specific factors may play an important role in increasing CVD risk, with changes in sex hormones, body fat distribution, lipid and...
Agonists, inverse agonists, and antagonists as therapeutic approaches to manipulate retinoic acid-related orphan receptors [0.03%]
激动剂、反向激动剂和拮抗剂在操纵视黄酸相关孤儿受体中的治疗作用
Darya Nematisouldaragh,Huong Nguyen,Inna Rabinovich-Nikitin
Darya Nematisouldaragh
Retinoic acid-related orphan receptors (RORs) serve as transcription factors that play a pivotal role in a myriad of physiological processes within the body. Their involvement extends to critical biological processes that confer protective ...
Coronary Microvascular Disease in Women: Epidemiology, Mechanisms, Evaluation, and Treatment [0.03%]
女性冠状动脉微血管疾病的流行病学、机制、评估和治疗
Rebecca Steinberg,Anamaria Dragan,Puja Mehta et al.
Rebecca Steinberg et al.
Coronary microvascular dysfunction (CMD) involves functional or structural abnormalities of the coronary microvasculature resulting in dysregulation of coronary blood flow (CBF) in response to myocardial oxygen demand. This perfusion mismat...
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy [0.03%]
细胞色素P450 1B1在肿瘤坏死因子-α、白介素-6和LPS诱导的细胞肥大发病机制中起关键作用
Mohammed A W ElKhatib,Samar H Gerges,Fadumo A Isse et al.
Mohammed A W ElKhatib et al.
Heart failure (HF) is preceded by cellular hypertrophy (CeH) which alters expression of cytochrome P450 enzymes (CYPs) and arachidonic acid (AA) metabolism. Inflammation is involved in CeH pathophysiology, but mechanisms remain elusive. Thi...
Priyanka Mungara,Moubarak Waiss,Sunny Hartwig et al.
Priyanka Mungara et al.
Kidney anion exchanger 1 (kAE1) is an isoform of the AE1 protein encoded by the SLC4A1 gene. It is a basolateral membrane protein expressed by α-intercalated cells in the connecting tubules and collecting duct of the kidney. Its main funct...
Low-fat cheese ameliorates glucose intolerance and normalizes insulin secretion in a rat model of type 2 diabetes by promoting β-cell recovery [0.03%]
低脂奶酪通过促进β细胞恢复来改善2型糖尿病模型大鼠的糖耐量和恢复正常胰岛素分泌
Anik R Z Hanning,Mortaza Fatehi Hassanabad,Zohre Hashemi et al.
Anik R Z Hanning et al.
We aimed to determine if cheese could reduce glucose intolerance in aged rats with overt type 2 diabetes (T2D). Male Sprague-Dawley rats treated with high-fat diet (HFD) and streptozotocin (STZ) to elicit T2D were hyperglycemic. One week af...
Hannah Zhang,Ashish Shah,Amir Ravandi
Hannah Zhang
Cardiogenic shock (CS) remains a high-mortality condition despite technological and therapeutic advances. One key to potentially improving CS prognosis is understanding patient heterogeneity and which patients may benefit most from differen...
Discontinuing semaglutide after weight loss: strategy for weight maintenance and a possible new side effect [0.03%]
司美格鲁肽减重后的停药：体重维持策略及可能的副作用探讨
Nicholas W Carris,Shawn Wallace,Christopher G DuCoin et al.
Nicholas W Carris et al.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) facilitate weight loss. Weight regain off therapy is concerning. We reported the case of a 35-year-old male prescribed oral semaglutide with 22.7 kg weight loss over 120 days. Herein, we...