Chemical synthesis, in vitro testing and in silico Nampt-based molecular docking of novel aniline aromatic ring-substituted 2-Aminothiazole analogues [0.03%]
新型苯胺芳环取代的2-氨基噻唑类似物的化学合成、体外检测及基于Nampt的分子对接计算机辅助模拟研究
Ali A Husain,Ravikumar Manickam,Jonah Gordon et al.
Ali A Husain et al.
The heterocyclic 2-Aminothiazoles scaffolds are used in a wide range of therapeutic applications against various diseases for its antioxidant, anti-inflammatory, antimicrobial and anticancer actions. In the present study, we synthesized nov...
Evaluation of the effects of pioglitazone on perivascular adipose tissue function, properties, and structure in a rat model of type-2 diabetes [0.03%]
评估吡格列酮对2型糖尿病大鼠模型血管周围脂肪组织功能、特性和结构的影响
Erkan Civelek,Ecem Fatma Karaman,Sibel Özden et al.
Erkan Civelek et al.
Perivascular adipose tissue (PVAT) plays an important role in many physiological and pathological processes, such as regulation of vascular tone. The aim of this study is to evaluate the effects of pioglitazone on functional, structural, an...
Ynuk Bossé
Ynuk Bossé
Research on airway smooth muscle has traditionally focused on its putative detrimental role in asthma, emphasizing on how its shortening narrows the airway lumen, without much consideration about its potential role in subserving the functio...
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice [0.03%]
奈必洛尔预防环磷酰胺诱导的小鼠下泌尿道氧化应激及功能障碍
Carolina P S Jesus,Gustavo F Pimenta,Mariana G de Oliveira et al.
Carolina P S Jesus et al.
Cyclophosphamide (CYP) is combined with cytoprotective agents to minimize its toxicity in the bladder, which is mediated by reactive oxygen species (ROS). Using multiple antioxidant mechanisms, nebivolol protects from oxidative stress in di...
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease [0.03%]
冠状动脉疾病中独立预测因素的腔内超声评价(epicardial脂肪组织厚度)
Laurentiu Braescu,Adrian Sturza,Raluca Sosdean et al.
Laurentiu Braescu et al.
This study aimed to assess the utility of echocardiography-measured epicardial adipose tissue (EAT) thickness (EATT) as an independent predictor for coronary artery disease (CAD), examining its correlation with oxidative stress levels in ep...
Behavioral dynamics of medicinal signaling cells from porcine bone marrow in long-term culture [0.03%]
源自猪骨髓的医药信号细胞长期培养中的行为动态学研究
Wanderson Gabriel Gomes de Melo,Dayseanny de Oliveira Bezerra,Elis Rosélia Dutra de Freitas Siqueira Silva et al.
Wanderson Gabriel Gomes de Melo et al.
Medicinal signaling cells (MSC) hold promise for regenerative medicine due to their ability to repair damaged tissues. However, their effectiveness can be affected by how long they are cultured in the lab. This study investigated how passag...
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets [0.03%]
sarcopenia：最近用于检测、疾病进展和代谢变化及其治疗靶点的研究成果
Syeda Roohina Ali,Augustine T Nkembo,Srinivas M Tipparaju et al.
Syeda Roohina Ali et al.
Sarcopenia, a disorder marked by muscle loss and dysfunction, is a global health concern, particularly in aging populations. Sarcopenia is intricately related to various health conditions, including obesity, dysphagia, and frailty, which un...
Retraction: Endothelin axis induces metalloproteinase activation and invasiveness in human lymphatic endothelial cells [0.03%]
撤回：内皮素轴诱导人淋巴内皮细胞的金属蛋白酶活化和侵袭性
Canadian Journal of Physiology and Pharmacology Editor
Canadian Journal of Physiology and Pharmacology Editor
Retraction of Publication
Canadian journal of physiology and pharmacology. 2024 Nov 1;102(11):681. DOI:10.1139/cjpp-2024-0264 2024